Intrahepatic bile duct adenoma with oncocytic features

Hastir, Delfyne; Verset, Laurine; Demetter, Pieter

doi:10.1111/j.1478-3231.2012.02866.x

Cited by 7 publications

(1 citation statement)

References 3 publications

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“…Although several oncocytic liver, biliary, and pancreatic neoplasms have been described, only two cases of bile duct adenomas with oncocytic change have been reported in the literature. One case occurred in a 57-year-old woman [ 2 ] and the other in a 68-year-old man [ 3 ]. In both cases, the reports described a proliferation of bile ducts composed of cytologically bland cells with round nuclei.…”

Section: Discussionmentioning

confidence: 99%

Bile Duct Adenoma with Oncocytic Features

Johannesen

Holly

2014

Case Reports in Pathology

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Bile duct adenomas are benign bile duct proliferations usually encountered as an incidental finding. Oncocytic bile duct neoplasms are rare and the majority are malignant. A 61-year-old male with a diagnosis of colorectal adenocarcinoma was undergoing surgery when a small white nodule was discovered on the surface of the right lobe of his liver. This lesion was composed of cytologically bland cells arranged in tightly packed glands. These cells were immunopositive for cytokeratin 7, negative for Hep Par 1, contained mucin, and had a Ki67 proliferation index of 8%. The morphology, immunophenotype, presence of mucin, and normal appearing bile ducts, as well as the increased Ki67 proliferation rate, were consistent with a bile duct adenoma with oxyphilic (oncocytic) change. Oncocytic tumors in the liver are rare; the first described in 1992. Only two bile duct adenomas with oncocytic change have been reported and neither of them had reported mucin production or the presence of normal appearing bile ducts within the lesion.

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Section: Discussionmentioning

confidence: 99%