1978
DOI: 10.1016/0047-0740(78)90150-x
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Intrahepatic aterial 90-yttrium resin spheres to treat liver cancer

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1983
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Cited by 13 publications
(3 citation statements)
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“…In respect to metastatic spread to the liver, long-term survival is determined by the tumor biology and the propensity for extra-hepatic disease [3]. A recent advance in the treatment of these tumors is the use of selective internal radiation therapy (SIRT) with yttrium-90 (Y 90 ) microspheres, described as direct intratumoral injection, with transarteril administration in humans, first described as feasible, and then later with the ability to induce tumor necrosis and regression [4,5].…”
Section: Introductionmentioning
confidence: 99%
“…In respect to metastatic spread to the liver, long-term survival is determined by the tumor biology and the propensity for extra-hepatic disease [3]. A recent advance in the treatment of these tumors is the use of selective internal radiation therapy (SIRT) with yttrium-90 (Y 90 ) microspheres, described as direct intratumoral injection, with transarteril administration in humans, first described as feasible, and then later with the ability to induce tumor necrosis and regression [4,5].…”
Section: Introductionmentioning
confidence: 99%
“…Resin-based microspheres have a lower specific activity per particle and thus require more particles to achieve any given dose. Glass-based microspheres are routinely delivered as a complete dose with little embolic effect at a potentially greater dosage with larger parenchymal coverage (16,17). No direct comparison of the efficacy of the two microsphere products has been reported in the literature.…”
Section: Vehicles Delivering 90 Y: Resin and Glass Microspheresmentioning
confidence: 99%
“…The use of 90 Y to treat these diseases began with its topical application and direct intratumoral injection. Transarterial administration of 90 Y-bearing microspheres in humans was described in the early literature as feasible (7)(8)(9), and, somewhat later, as capable of inducing tumor regression (10). The results of numerous subsequent studies have supported the use and confirmed the effectiveness of 90 Y-bearing microspheres in the treatment of hepatic primary neoplasms (11)(12)(13)(14)(15) and metastatic neoplasms (16 -18).…”
Section: Introductionmentioning
confidence: 99%