Intrahepatic and widely distributed intraabdominal splenosis: multidetector CT, US and scintigraphic findings

Contribution of Tc-99m RBC SPECT/ CT in Intrahepatic and Peritoneal Splenosis Mimicking Malignancy

“…99mTc-labeled heat-damaged RBC scintigraphy and Indium 111-labeled platelets scintigraphy are more sensitive and specifi c for the diagnosis of splenic sequestration and phagocytosis than Tc99m sulphur colloid scanning because of their better signalto-background ratio, and their specifi city for splenic tissue [1,5]. 99mTc-labeled heat-damaged RBC scintigraphy is actually considered as the ''gold standard'' test to establish the diagnosis of splenosis [14]. The performance of 99mTc-labelled heat-damaged RBC SPECT/CT allows the non-invasive diagnosis of this entity and avoids more aggressive diagnostic techniques but for some untypical cases, tissue sampling for pathologic diagnosis is still necessary [14].…”

“…99mTc-labeled heat-damaged RBC scintigraphy is actually considered as the ''gold standard'' test to establish the diagnosis of splenosis [14]. The performance of 99mTc-labelled heat-damaged RBC SPECT/CT allows the non-invasive diagnosis of this entity and avoids more aggressive diagnostic techniques but for some untypical cases, tissue sampling for pathologic diagnosis is still necessary [14]. In a recent comprehensive study, Ekmekçi et al reported that Tc-99m RBC SPECT/CT has a high specifi city in the detection of accessory spleens/splenosis [15].…”

Pelvic splenosis mimicking ovarian metastasis of breast carcinoma: a case report

“…It is supposed that the number of nodules of ectopic splenic tissue that develop in the peritoneal cavity correlates with the severity of splenic injury. Another mechanism of splenic tissue transplantation is splenic vein emboli or hematogenous spread of splenic pulp, which is suggested by cases of intrahepatic and intracranial splenosis (13,14). One theory suggests that splenic erythrocytic progenitor cells enter the liver via the portal vein, and then grow in response to tissue hypoxia (15).…”

Intraperitoneal splenosis: CT and MRI evaluation

“…Another mechanism of splenic tissue transplantation is splenic vein emboli or hematogenous spread of splenic pulp, which is suggested by cases of intrahepatic and intracranial splenosis (5,(12)(13)(14). One theory suggests that splenic erythrocytic progenitor cells enter the liver via the portal vein, and then grow in response to tissue hypoxia (15).…”

“…Additionally, single positron emission tomography has the advantage of direct correlation with other imaging techniques. Tc-99m heat-damaged erythrocytes or In-111 labeled platelets are more sensitive than Tc-99m sulfur colloid in the detection of this tissue because of their better signal-to-background ratio, and their specificity for splenic tissue (13,20,21).…”