Intragraft gene and protein expression in rat liver allografts treated with costimulatory blockade alone or in combination with CyA

Bartlett, Adam; McCall, John L.; Ameratunga, Rohan; Howden, B O; Ramadas, Ravi; Yeong, Mee Ling; Benjamin, Christopher D.; Hess, Donna M.; Munn, Stephen

doi:10.1016/s0022-4804(03)00131-8

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…To further explore our SAGE results, we compared the entire SAGE database with 10 transplantation-related gene expression profile studies, which published from 2002 to 2009 (5,6,11,20,24,42–44,53,70). We collected a total of 262 genes (data not shown) for the comparison in this part.…”

Section: Resultsmentioning

confidence: 99%

“…An approach to molecularly determine the cause of allograft rejections is to identify specific genes that are involved in the rejections. In recent years, gene expression profiling has been increasingly used in organ transplantation studies, including liver, heart, pancreas, kidney, and lung transplantations, by cDNA microarray or real-time RT-PCR (5,6,11,20, 24,37,42–44,70). While studies have identified allograft rejection-related genes involved in apoptosis, cytokines, cytotoxic molecule, and cell adhesion (12,55,58), it is not clear how many genes are involved in allograft rejection at the genome level.…”

Section: Introductionmentioning

confidence: 99%

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Alternatively Expressed Genes Identified in the CD4⁺ T Cells of Allograft Rejection Mice

Wang

Zhang

et al. 2011

Cell Transplant

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Allograft rejection is a leading cause for the failure of allotransplantation. CD4+ T cells play critical roles in this process. The identification of genes that alternatively expressed in CD4 + T cells during allograft rejection will provide critical information for studying the mechanism of allograft rejection, finding specific gene markers for monitoring, predicting allograft rejection, and opening new ways to regulate and prevent allograft rejection. Here, we established allograft and isograft transplantation models by adoptively transferring wild-type BALB/c mouse CD4+ T cells into severe combined immunodeficient (SCID) mice with a C57BL/ 6 or BALB/c mouse skin graft. Using the whole transcriptome sequencing-based serial analysis of gene expression (SAGE) technology, we identified 97 increasingly and 88 decreasingly expressed genes that may play important roles in allograft rejection and tolerance. Functional classification of these genes shows that apoptosis, transcription regulation, cell growth and maintenance, and signal transduction are among the frequently changed functional groups. This study provides a genome-wide view for the candidate genes of CD4 + T cells related to allotransplantation, and this report is a good resource for further microarray studies and for identifying the specific markers that are associated with clinical organ transplantations.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Alternatively Expressed Genes Identified in the CD4⁺ T Cells of Allograft Rejection Mice

Wang

Zhang

et al. 2011

Cell Transplant

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“…Some studies have suggested that concomitant administration of CNI or steroids antagonizes the tolerogenic effect of costimulatory blockade 98. However, this remains somewhat controversial 99…”

Section: Future Prospects For Cni‐free Immunosuppressionmentioning

confidence: 99%

Immunosuppression in liver transplantation: Beyond calcineurin inhibitors

et al. 2005

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The CD154-CD40 costimulation pathway in organ transplantation

Zhai

Kupiec‐Weglinski

2004

Transplantation Reviews

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Intragraft gene and protein expression in rat liver allografts treated with costimulatory blockade alone or in combination with CyA

Cited by 5 publications

References 28 publications

Alternatively Expressed Genes Identified in the CD4⁺ T Cells of Allograft Rejection Mice

Alternatively Expressed Genes Identified in the CD4⁺ T Cells of Allograft Rejection Mice

Immunosuppression in liver transplantation: Beyond calcineurin inhibitors

The CD154-CD40 costimulation pathway in organ transplantation

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Intragraft gene and protein expression in rat liver allografts treated with costimulatory blockade alone or in combination with CyA

Cited by 5 publications

References 28 publications

Alternatively Expressed Genes Identified in the CD4+ T Cells of Allograft Rejection Mice

Alternatively Expressed Genes Identified in the CD4+ T Cells of Allograft Rejection Mice

Immunosuppression in liver transplantation: Beyond calcineurin inhibitors

The CD154-CD40 costimulation pathway in organ transplantation

Contact Info

Product

Resources

About

Alternatively Expressed Genes Identified in the CD4⁺ T Cells of Allograft Rejection Mice

Alternatively Expressed Genes Identified in the CD4⁺ T Cells of Allograft Rejection Mice