Intragastric injection of Lactobacillus casei strain Shirota suppressed spleen sympathetic activation by central corticotrophin-releasing factor or peripheral 2-deoxy-d-glucose in anesthetized rats

Tanida, Mamoru; Takada, Mai; Kato-Kataoka, Akito; Kawai, Mitsuhisa; Miyazaki, Katsumi; Shibamoto, Toshishige

doi:10.1016/j.neulet.2016.03.016

Cited by 14 publications

(9 citation statements)

References 21 publications

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“… 11 Continuous ingestion of 100 ml of fermented milk containing 100 billion live LcS for 8 weeks relieves temporary stress 15 - 17 and improves sleep quality. 18 These effects are induced through the vagus nerve, 16 , 30 which is spread throughout the gastrointestinal tract. Because the intestinal microbiota is occupied by the ingested LcS for a period of time, there is adequate opportunity for the ingested LcS to continuously stimulate the immune cells, nerve cells, and glia cells in the upper gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 99%

Dynamic analysis of human small intestinal microbiota after an ingestion of fermented milk by small-intestinal fluid perfusion using an endoscopic retrograde bowel insertion technique

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Dynamic analysis of human small intestinal microbiota after an ingestion of fermented milk by small-intestinal fluid perfusion using an endoscopic retrograde bowel insertion technique

et al. 2020

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“…From an earlier study (756), this strain was known to decrease CRD-evoked bradycardia and single unit dorsal root fiber discharge in the anesthetized rat. Direct gastric administration of L. casei Shirota strain has been shown to potentially act on the afferent vagal nerve, decreasing sympathetic nerve outflow and regulating tissue-specific efferent sympathetic nervous activity via the CNS (1461). It has become apparent that commensal bacteria can signal to local sensory neurons to alter their excitability state, which itself can last long after the bacteria have been removed (1462), somewhat reminiscent of hippocampal synaptic plasticity.…”

Section: Prebiotics Probiotics and Ens Implications For Synaptic Plasticitymentioning

confidence: 99%

The Microbiota-Gut-Brain Axis

Cryan

O’Riordan

Cowan

et al. 2019

Physiological Reviews

2,796

2,066

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The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, the past 15 yr have seen the emergence of the microbiota (the trillions of microorganisms within and on our bodies) as one of the key regulators of gut-brain function and has led to the appreciation of the importance of a distinct microbiota-gut-brain axis. This axis is gaining ever more traction in fields investigating the biological and physiological basis of psychiatric, neurodevelopmental, age-related, and neurodegenerative disorders. The microbiota and the brain communicate with each other via various routes including the immune system, tryptophan metabolism, the vagus nerve and the enteric nervous system, involving microbial metabolites such as short-chain fatty acids, branched chain amino acids, and peptidoglycans. Many factors can influence microbiota composition in early life, including infection, mode of birth delivery, use of antibiotic medications, the nature of nutritional provision, environmental stressors, and host genetics. At the other extreme of life, microbial diversity diminishes with aging. Stress, in particular, can significantly impact the microbiota-gut-brain axis at all stages of life. Much recent work has implicated the gut microbiota in many conditions including autism, anxiety, obesity, schizophrenia, Parkinson’s disease, and Alzheimer’s disease. Animal models have been paramount in linking the regulation of fundamental neural processes, such as neurogenesis and myelination, to microbiome activation of microglia. Moreover, translational human studies are ongoing and will greatly enhance the field. Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.

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“…Notably, although BA is produced in the gut, the effects of BA on the gut-circulatory system axis have not been evaluated. The latter is important as ample research shows that gut signaling plays a significant role in interactions between gut microbiota and the host [5, 27].…”

Section: Introductionmentioning

confidence: 99%

Butyric acid, a gut bacteria metabolite, lowers arterial blood pressure via colon-vagus nerve signaling and GPR41/43 receptors

Onyszkiewicz

Gawrys-Kopczynska

Konopelski

et al. 2019

Pflugers Arch - Eur J Physiol

115

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Butyric acid (BA) is a short-chain fatty acid (SCFA) produced by gut bacteria in the colon. We hypothesized that colon-derived BA may affect hemodynamics. Arterial blood pressure (BP) and heart rate (HR) were recorded in anesthetized, male, 14-week-old Wistar rats. A vehicle, BA, or 3-hydroxybutyrate, an antagonist of SCFA receptors GPR41/43 (ANT) were administered intravenously (IV) or into the colon (IC). Reactivity of mesenteric (MA) and gracilis muscle (GMA) arteries was tested ex vivo. The concentration of BA in stools, urine, portal, and systemic blood was measured with liquid chromatography coupled with mass spectrometry. BA administered IV decreased BP with no significant effect on HR. The ANT reduced, whereas L-NAME, a nitric oxide synthase inhibitor, did not affect the hypotensive effect of BA. In comparison to BA administered intravenously, BA administered into the colon produced a significantly longer decrease in BP and a decrease in HR, which was associated with a 2–3-fold increase in BA colon content. Subphrenic vagotomy and IC pretreatment with the ANT significantly reduced the hypotensive effect. Ex vivo, BA dilated MA and GMA. In conclusion, an increase in the concentration of BA in the colon produces a significant hypotensive effect which depends on the afferent colonic vagus nerve signaling and GPR41/43 receptors. BA seems to be one of mediators between gut microbiota and the circulatory system.Electronic supplementary materialThe online version of this article (10.1007/s00424-019-02322-y) contains supplementary material, which is available to authorized users.

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Intragastric injection of Lactobacillus casei strain Shirota suppressed spleen sympathetic activation by central corticotrophin-releasing factor or peripheral 2-deoxy-d-glucose in anesthetized rats

Cited by 14 publications

References 21 publications

Dynamic analysis of human small intestinal microbiota after an ingestion of fermented milk by small-intestinal fluid perfusion using an endoscopic retrograde bowel insertion technique

Dynamic analysis of human small intestinal microbiota after an ingestion of fermented milk by small-intestinal fluid perfusion using an endoscopic retrograde bowel insertion technique

The Microbiota-Gut-Brain Axis

Butyric acid, a gut bacteria metabolite, lowers arterial blood pressure via colon-vagus nerve signaling and GPR41/43 receptors

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