Intrafascicular stimulation of monkey arm nerves evokes coordinated grasp and sensory responses

Ledbetter, Noah M.; Éthier, Christian; Oby, Emily R.; Hiatt, Scott; Wilder, Andrew M.; Ko, Jason H.; Agnew, Sonya P.; Miller, Lee E.; Clark, Gregory A.

doi:10.1152/jn.00688.2011

Cited by 56 publications

(43 citation statements)

References 42 publications

(40 reference statements)

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“…We are investigating approaches for providing better array stability, such as an overlay of cyanoacrylate. A metal mesh encapsulated with a silicone elastomer like Kwik-Cast (World Precision Instruments, Sarasota, FL, USA) may also be a viable means of stabilizing the arrays [22]. …”

Section: Discussionmentioning

confidence: 99%

Chronic monitoring of lower urinary tract activity via a sacral dorsal root ganglia interface

et al. 2017

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Objective Our goal is to develop an interface that integrates chronic monitoring of lower urinary tract (LUT) activity with stimulation of peripheral pathways. Approach Penetrating microelectrodes were implanted in sacral dorsal root ganglia (DRG) of adult male felines. Peripheral electrodes were placed on or in the pudendal nerve, bladder neck and near the external urethral sphincter. Supra-pubic bladder catheters were implanted for saline infusion and pressure monitoring. Electrode and catheter leads were enclosed in an external housing on the back. Neural signals from microelectrodes and bladder pressure of sedated or awake-behaving felines were recorded under various test conditions in weekly sessions. Electrodes were also stimulated to drive activity. Main results LUT single- and multi-unit activity was recorded for 4 to 11 weeks in four felines. As many as 18 unique bladder pressure single-units were identified in each experiment. Some channels consistently recorded bladder afferent activity for up to 41 days, and we tracked individual single-units for up to 23 days continuously. Distension-evoked and stimulation-driven (DRG and pudendal) bladder emptying was observed, during which LUT sensory activity was recorded. Significance This chronic implant animal model allows for behavioral studies of LUT neurophysiology and will allow for continued development of a closed-loop neuroprosthesis for bladder control.

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Section: Discussionmentioning

confidence: 99%

Chronic monitoring of lower urinary tract activity via a sacral dorsal root ganglia interface

et al. 2017

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“…Alternate electrode interfaces may address the fatigue (figure 5) and incomplete muscle recruitment seen in this study, such as the variance in step lengths between cats I and K (table 1). Peripheral nerve stimulation with cuff [22, 48, 49] or penetrating electrodes [10, 50–52] or recruitment of muscle synergies via intraspinal microstimulation [7, 9, 53] may lead to a more natural activation of limb muscles while requiring fewer electrodes and lower currents than direct muscle stimulation [47]. Integration of the feedback controller demonstrated here with an improved FES system may yield clinically relevant muscle recruitment and locomotion.…”

Section: Discussionmentioning

confidence: 99%

Real-time control of hind limb functional electrical stimulation using feedback from dorsal root ganglia recordings

Bruns¹,

Wagenaar²,

Bauman³

et al. 2013

J. Neural Eng.

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Objective Functional electrical stimulation (FES) approaches often utilize an open-loop controller to drive state transitions. The addition of sensory feedback may allow for closed-loop control that can respond effectively to perturbations and muscle fatigue. Approach We evaluated the use of natural sensory nerve signals obtained with penetrating microelectrode arrays in lumbar dorsal root ganglia (DRG) as real-time feedback for closed-loop control of FES-generated hind limb stepping in anesthetized cats. Main results Leg position feedback was obtained in near real-time at 50 ms intervals by decoding the firing rates of more than 120 DRG neurons recorded simultaneously. Over 5 m of effective linear distance was traversed during closed-loop stepping trials in each of two cats. The controller compensated effectively for perturbations in the stepping path when DRG sensory feedback was provided. The presence of stimulation artifacts and the quality of DRG unit sorting did not significantly affect the accuracy of leg position feedback obtained from the linear decoding model as long as at least 20 DRG units were included in the model. Significance This work demonstrates the feasibility and utility of closed-loop FES control based on natural neural sensors. Further work is needed to improve the controller and electrode technologies and to evaluate long-term viability.

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“…1F) (38). In particular, intrafascicular electrodes enabled access to intrinsic hand muscles that cannot be recruited independently using conventional FES (56). Complex reach-to-grasp movements have also been evoked in NHPs when delivering intraspinal microstimulation at specific locations of cervical segments (Fig.…”

Section: Restoration: a Conversation With The Nervous Systemmentioning

confidence: 99%

Personalized Neuroprosthetics

et al. 2013

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Intrafascicular stimulation of monkey arm nerves evokes coordinated grasp and sensory responses

Abstract: GA. Intrafascicular stimulation of monkey arm nerves evokes coordinated grasp and sensory responses.

Cited by 56 publications

References 42 publications

Chronic monitoring of lower urinary tract activity via a sacral dorsal root ganglia interface

Chronic monitoring of lower urinary tract activity via a sacral dorsal root ganglia interface

Real-time control of hind limb functional electrical stimulation using feedback from dorsal root ganglia recordings

Personalized Neuroprosthetics

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