Intrafamilial Cluster of Pulmonary Tuberculosis Due to
            <i>Mycobacterium bovis</i>
            of the African 1 Clonal Complex

Godreuil, Sylvain; Jeziorski, Éric; Bañuls, Anne‐Laure; Fraisse, T.; Perre, Philippe Van de; Boschiroli, Maria‐Laura

doi:10.1128/jcm.01645-10

Cited by 13 publications

(6 citation statements)

References 16 publications

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“…Different routes of contamination could be responsible for the infection: i) contamination by a common animal or food-borne source; ii) human to human transmission. Indeed inter-human transmission cannot be excluded since intra-familial and community based transmissions of human TB cases due to Af1 strains of M. bovis have been already suspected [36] , [37] .…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium bovis in Burkina Faso: Epidemiologic and Genetic Links between Human and Cattle Isolates

et al. 2014

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BackgroundIn sub-Saharan Africa, bovine tuberculosis (bTB) is a potential hazard for animals and humans health. The goal of this study was to improve our understanding of bTB epidemiology in Burkina Faso and especially Mycobacterium bovis transmission within and between the bovine and human populations.Methodology/principal findingsTwenty six M. bovis strains were isolated from 101 cattle carcasses with suspected bTB lesions during routine meat inspections at the Bobo Dioulasso and Ouagadougou slaughterhouses. In addition, 7 M. bovis strains were isolated from 576 patients with pulmonary tuberculosis. Spoligotyping, RDAf1 deletion and MIRU-VNTR typing were used for strains genotyping. The isolation of M. bovis strains was confirmed by spoligotyping and 12 spoligotype signatures were detected. Together, the spoligotyping and MIRU-VNTR data allowed grouping the 33 M. bovis isolates in seven clusters including isolates exclusively from cattle (5) or humans (1) or from both (1). Moreover, these data (genetic analyses and phenetic tree) showed that the M. bovis isolates belonged to the African 1 (Af1) clonal complex (81.8%) and the putative African 5 (Af5) clonal complex (18.2%), in agreement with the results of RDAf1 deletion typing.Conclusions/SignificanceThis is the first detailed molecular characterization of M. bovis strains from humans and cattle in Burkina Faso. The distribution of the two Af1 and putative Af5 clonal complexes is comparable to what has been reported in neighbouring countries. Furthermore, the strain genetic profiles suggest that M. bovis circulates across the borders and that the Burkina Faso strains originate from different countries, but have a country-specific evolution. The genetic characterization suggests that, currently, M. bovis transmission occurs mainly between cattle, occasionally between cattle and humans and potentially between humans. This study emphasizes the bTB risk in cattle but also in humans and the difficulty to set up proper disease control strategies in Burkina Faso.

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Section: Discussionmentioning

confidence: 99%

Mycobacterium bovis in Burkina Faso: Epidemiologic and Genetic Links between Human and Cattle Isolates

et al. 2014

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“…Thus zoonotic TB is of particular concern for developing countries, but where bTB controls are effective, human M. bovis or M. caprae isolates are uncommon and rare in countries where bTB has been eradicated [ 2 , 16 , 18 , 22 , 26 , 27 ]. M. bovis may affect humans of any age, and while the majority opinion is that human-to-human spread of M. bovis must be a very rare event, it does occur particularly amongst immunocompromised individuals [ 16 , 25 , 28 – 30 ]. O'Reilly and Daborn also referred to a small outbreak of tuberculosis in The Netherlands in 1994 caused by M. bovis which likely involved transmission from human to human [ 7 ].…”

Section: Zoonotic Implicationsmentioning

confidence: 99%

Perspectives on the History of Bovine TB and the Role of Tuberculin in Bovine TB Eradication

Good¹,

Duignan²

2011

Veterinary Medicine International

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Tuberculosis remains a significant disease of animals and humans worldwide. Bovine tuberculosis is caused by Mycobacteria with an extremely wide host range and serious, although currently probably underdiagnosed, zoonotic potential. Where bovine tuberculosis controls are effective, human zoonotic TB, due to Mycobacterium bovis or M. caprae, is uncommon and clinical cases are infrequent in cattle. Therefore, the control and ultimate eradication of bovine tuberculosis is desirable. Tuberculin tests are the primary screening tool used in bovine eradication. The choice of tuberculin test is dependent on the environment in which it is to be used. Tuberculin potency is critical to test performance, and the accurate determination of potency is therefore particularly important. The design of a control or eradication programme should take into consideration the fundamental scientific knowledge, the epidemiological profile of disease, the experience of other eradication programmes, and the presence, in the same ecosystem, of maintenance hosts, in which infection is self-sustaining and which are capable of transmitting infection. A control or eradication programme will necessarily require modification as it progresses and must be under constant review to identify the optimal desirable goals, the efficacy of policy, and constraints to progress.

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“…In animals, bTB has been reported from 33 of 43 African countries (Ayele et al 2004 ). Human cases of bTB have been described in Ghana, Niger, Uganda and Tanzania (Idigbe et al 1986 ; Addo et al 2007 ; Oloya et al 2008 ) and in immigrants from Chad (Godreuil et al 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Zoonotic Transmission of Tuberculosis Between Pastoralists and Their Livestock in South-East Ethiopia

et al. 2012

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Despite huge global efforts in tuberculosis (TB) control, pastoral areas remain under-investigated. During two years sputum and fine needle aspirate (FNA) specimens were collected from 260 Ethiopian pastoralists of Oromia and Somali Regional States with suspected pulmonary TB and from 32 cases with suspected TB lymphadenitis. In parallel, 207 suspected tuberculous lesions were collected from cattle, camels and goats at abattoirs. All specimens were processed and cultured for mycobacteria; samples with acid-fast stained bacilli (AFB) were further characterized by molecular methods including genus and deletion typing as well as spoligotyping. Non-tuberculous mycobacteria (NTM) were sequenced at the 16S rDNA locus. Culturing of AFB from human sputum and FNA samples gave a yield of 174 (67%) and 9 (28%) isolates, respectively. Molecular typing was performed on 173 of these isolates and 160 were confirmed as Mycobacterium tuberculosis, three as M. bovis, and the remaining 10 were typed as NTMs. Similarly, 48 AFB isolates (23%) yielded from tuberculous lesions of livestock, of which 39 were molecular typed, including 24 M. bovis and 4 NTMs from cattle, 1 M. tuberculosis and 1 NTM from camels and 9 NTMs from goats. Isolation of M. bovis from humans and M. tuberculosis from livestock suggests transmission between livestock and humans in the pastoral areas of South-East Ethiopia

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Intrafamilial Cluster of Pulmonary Tuberculosis Due to Mycobacterium bovis of the African 1 Clonal Complex

Cited by 13 publications

References 16 publications

Mycobacterium bovis in Burkina Faso: Epidemiologic and Genetic Links between Human and Cattle Isolates

Mycobacterium bovis in Burkina Faso: Epidemiologic and Genetic Links between Human and Cattle Isolates

Perspectives on the History of Bovine TB and the Role of Tuberculin in Bovine TB Eradication

Zoonotic Transmission of Tuberculosis Between Pastoralists and Their Livestock in South-East Ethiopia

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