Intraexaminer and interexaminer reliability in the diagnosis of oral epithelial dysplasia

Abbey, Louis M.; Kaugars, George E.; Gunsolley, John C.; Burns, James C.; Page, Dennis G.; Svirsky, John A.; Eisenberg, Ellen; Krutchkoff, David J.; Cushing, Mark

doi:10.1016/s1079-2104(05)80201-x

Cited by 284 publications

(219 citation statements)

References 6 publications

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“…The transformation rate is dependent on the severity of the dysplasia, which needs to be carefully assessed to determine the risk of malignancy. Some studies have shown that presence of Oral Epithelial Dysplasia (OED) in OPML as the most reliable factors predicting malignant transformation (Abbey et al, 1995). But there are other studies contradicting the presence of epithelial dysplasia in the biopsy not being a significant factor for malignant development (Holmstrup et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

p53 Expression Helps Identify High Risk Oral Tongue Premalignant Lesions and Correlates with Patterns of Invasive Tumour Front and Tumour Depth in Oral Tongue Squamous Cell Carcinoma Cases

Thangaraj

Shyamsundar²,

Ramani³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Oral tongue squamous cell carcinoma (OTSCC) is the most common oral cancer subtype with a maximum propensity for regional spread. Our objective was to study if p53 expression might have any correlation with aggressive patterns of invasion within oral tongue cancers as well as with the histologically identified degree of oral tongue dysplasia. p53 immunoexpression was studied using immunohistochemistry in early staged OTSCCs (n=155), oral tongue dysplasias, (n=29) and oral tongue normal specimens (n=10) and evaluated for correlations with histological and clinicopathological parameters. Our study (n=194) showed a pattern of p53 expression increasing with different grades of tongue dysplasia to different grades of invasive OTSCC (p=0.000). Among the OTSCC tumours, positive p53 expression was seen in 43.2% (67/155) and a higher p53 labelling index was significantly associated with increased Bryne's grade of the tumour invasive front (p=0.039) and increased tumour depth (p=0.018). Among the OTSCC patients with tobacco habits, (n=91), a higher p53 labelling index was significantly associated with increased risk of local recurrence (p=0.025) and with lymphovascular space involvement (p=0.014). Evaluation of p53 through varying degrees of dysplasia to oral tongue cancer indicates that p53 expression is linked to aggressive features of oral tongue cancers and tongue precancers entailing a closer monitoring in positive cases. Among the OTSCCs, p53 expression is associated with tumour aggressiveness correlating with increased grading of invasive tumour front and tumour depth.

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Section: Introductionmentioning

confidence: 99%

p53 Expression Helps Identify High Risk Oral Tongue Premalignant Lesions and Correlates with Patterns of Invasive Tumour Front and Tumour Depth in Oral Tongue Squamous Cell Carcinoma Cases

Thangaraj

Shyamsundar²,

Ramani³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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“…Conventional grading system: mild dysplasia, moderate dysplasia, severe dysplasia and carcinoma in situ. [18,19] 3. Ljubljana grading system: simple hyperplasia, abnormal hyperplasia, atypical hyperplasia, carcinoma in situ.…”

Section: Etiologymentioning

confidence: 99%

An Update on Precancerous Lesions of Oral Cavity

Goyal

Singh

et al. 2018

IJMDS

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“…Se incluyeron lesiones orales de características clínicas diversas, localizadas en varias regiones de la mucosa oral, 298 de las que eran Clase I de Sciubba y la mayoría (n=647) Clase II. Esto lo que está de acuerdo con los datos publicados en la literatura, ya que estas son las lesiones más prevalentes en poblaciones con estas características demográficas (19,23). Para el cálculo de las medidas de validez de la prueba se utilizó los datos de todas las lesiones de Clase I y II sometidas a ambos procedimientos diagnósticos, comparando los resultados de forma independiente.…”

Section: Biopsia Por Cepillado Con El Oralcdx ® : Estudios Clínicosunclassified

Biopsia por cepillado con el OralCDx®: Estado de la cuestión

Cruz¹,

Bascones-Martínez²

2013

Av Odontoestomatol

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RESUMENLa controversia en torno al OralCDx ® (OralScan Laboratories Inc., Suffern, Nueva York) se ha mantenido desde la publicación del primer estudio evaluando la validez y seguridad de esta prueba diagnóstica, como artículo de portada de la revista JADA en 1999. Aunque el estudio fue muy elogiado por algunos, otros han cuestionado la interpretación de la estadística y por consiguiente la aplicabilidad clínica de estos resultados. Esto dio lugar a lo que Greenberg designó la "controversia del cepillo" y a una incertidumbre, que aún hoy prevalece, en cuanto al uso de esta prueba diagnóstica. Entendemos que es importante llevar a cabo un análisis actualizado de la literatura que permita resumir la evidencia actual en torno al OralCDx ® . El objetivo de este artículo es realizar una revisión bibliográfica relacionada con la precisión del sistema de Test de cepillado OralCDx ® como técnica adyuvante de diagnóstico de LOMP. Se resumen datos acerca del diseño, muestras y características del grupo de estudio, intervenciones, resultados comunicados y medidas básicas de precisión diagnóstica de este método adyuvante, a partir de los estudios clínicos publicados entre los años de 1999 y 2013.Palabras clave: Cáncer oral, condiciones precancerosas, diagnóstico, biopsia por cepillado, análisis asistido por ordenador. SUMMARYThe controversy surrounding the OralCDx® (OralScan Laboratories Inc., Suffern, New York) has been on since the first study evaluating the validity and safety of this diagnostic test was published as cover story of the JADA in 1999. Although the study was highly praised by some, others have challenged the interpretation of the statistics and therefore the practical implications of these results. This resulted in what Greenberg called the "brush controversy" and in an uncertainty regarding the use of this diagnostic test that still prevails today. We believe it is important to conduct an updated review of the literature to summarize the current evidence regarding OralCDx®. The aim of this article is to review the literature regarding the accuracy of the OralCDx® brush biopsy in the detection or diagnosis of oral premalignant and malignant lesions (OPML). We abstracted data relating to study design, sampling and characteristics of the study group, interventions, reported outcomes and diagnostic accuracy of this adjunctive aid from the clinical studies published between 1999 and 2013.

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Intraexaminer and interexaminer reliability in the diagnosis of oral epithelial dysplasia

Cited by 284 publications

References 6 publications

p53 Expression Helps Identify High Risk Oral Tongue Premalignant Lesions and Correlates with Patterns of Invasive Tumour Front and Tumour Depth in Oral Tongue Squamous Cell Carcinoma Cases

p53 Expression Helps Identify High Risk Oral Tongue Premalignant Lesions and Correlates with Patterns of Invasive Tumour Front and Tumour Depth in Oral Tongue Squamous Cell Carcinoma Cases

An Update on Precancerous Lesions of Oral Cavity

Biopsia por cepillado con el OralCDx®: Estado de la cuestión

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