Intraethnic variation in steroid-5-alpha-reductase polymorphisms in prostate cancer patients: a potential factor implicated in 5-alpha-reductase inhibitor treatment

Abstract

. 2015 Intraethnic variation in steroid-5-alpha-reductase polymorphisms in prostate cancer patients: a potential factor implicated in 5-alpha-reductase inhibitor treatment. J. Genet. 94, [335][336][337][338][339][340][341]

Association between single-nucleotide polymorphisms in DNA double-strand break repair genes and prostate cancer aggressiveness in the Spanish population

“…Although it is a candidate gene study, we used an SNP tagging approach which reduces the bias inherit to the selection of well published SNPs and allows the inclusion of novel genetic variants with possible new biological roles. The phenomenon was previously observed in our series 23,24 , a fact explained by differences in the natural history of the populations 32,33 . As expected, the Andalusian population showed significant differences in genotype and allelic distribution, and subsequently, this subset of PCa patients was excluded from the association analyses to avoid the intra-ethnic bias.…”

“…Genotype analysis was performed with the same batch of chips and by the same investigator, as previously reported 5,23,24 .…”

“…We have previously shown that differences in the distribution of genotypes within different populations of the same ethnicity are an important confounding factor in genetics epidemiology 23,24 . Thus, we first analyzed the genotype distribution among subjects from different Spanish regions, highlighting that all PCa patients were from Caucasian origin.…”

Genetic variations in genes involved in testosterone metabolism are associated with prostate cancer progression: A Spanish multicenter study

“…Shibata et al and Jaffe et al published their results involving smaller cohorts of patients than our series, and Audet-Walsh et al included subjects from different ethnic origins. We have recently published that there is an important influence of ethnics in the analysis of genetic variations [15,16]. Together with differences in the genotype determination techniques or in the strategies for SNP analyzes, these could be plausible reasons to explain the differences observed between our results and those reported by others.…”

“…The patients were recruited from 4 different regions of Spain, as has been previously published [15]. As genotypic and allelic frequencies vary among subjects from these regions, and Andalusian patients showed the greatest differences [15,16], we excluded these subset of patients from further analyses to avoid bias. Patients who were initially operated were also excluded to form a homogenous group of patients with PCa.…”