Intraepithelial and infiltrative carcinoma of vulva: Bowen's type

Abell, Murray R.; Gosling, John

doi:10.1002/1097-0142(196103/04)14:2<318::aid-cncr2820140212>3.0.co;2-j

Cited by 93 publications

(22 citation statements)

References 11 publications

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“…However, it soon became clear that cutaneous intraepithelial lesions were of 2 types and perhaps of 2 different etiologies. In 1961, Abell and Gosling [55] described 2 distinct histopathologic types as intraepithelial carcinoma of Bowen's type and intraepithelial carcinoma simplex type. The natural history of these vulvar squamous intraepithelial lesions was not well understood.…”

Section: Cutaneous Terminologymentioning

confidence: 99%

The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: Background and Consensus Recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology

Darragh

Colgan

Cox

et al. 2012

Archives of Pathology &Amp; Laboratory Medicine

635

372

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The terminology for human papillomavirus (HPV)–associated squamous lesions of the lower anogenital tract has a long history marked by disparate diagnostic terms derived from multiple specialties. It often does not reflect current knowledge of HPV biology and pathogenesis. A consensus process was convened to recommend terminology unified across lower anogenital sites. The goal was to create a histopathologic nomenclature system that reflects current knowledge of HPV biology, optimally uses available biomarkers, and facilitates clear communication across different medical specialties. The Lower Anogenital Squamous Terminology (LAST) Project was cosponsored by the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology and included 5 working groups; 3 work groups performed comprehensive literature reviews and developed draft recommendations. Another work group provided the historical background and the fifth will continue to foster implementation of the LAST recommendations. After an open comment period, the draft recommendations were presented at a consensus conference attended by LAST work group members, advisors, and representatives from 35 stakeholder organizations including professional societies and government agencies. Recommendations were finalized and voted on at the consensus meeting. The final, approved recommendations standardize biologically relevant histopathologic terminology for HPV-associated squamous intraepithelial lesions and superficially invasive squamous carcinomas across all lower anogenital tract sites and detail the appropriate use of specific biomarkers to clarify histologic interpretations and enhance diagnostic accuracy. A plan for disseminating and monitoring recommendation implementation in the practicing community was also developed. The implemented recommendations will facilitate communication between pathologists and their clinical colleagues and improve accuracy of histologic diagnosis with the ultimate goal of providing optimal patient care.

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Section: Cutaneous Terminologymentioning

confidence: 99%

The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: Background and Consensus Recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology

Darragh

Colgan

Cox

et al. 2012

Archives of Pathology &Amp; Laboratory Medicine

635

372

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“…14 In 1977, the term ‘differentiated’ was used to highlight the highly differentiated histological features of the simplex type. 6 …”

Section: Evolution Of Nomenclature and Current Classificationmentioning

confidence: 99%

Squamous precursor lesions of the vulva: current classification and diagnostic challenges

et al. 2016

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Summary Growing evidence has established two major types of vulvar intraepithelial neoplasia (VIN), which correspond to two distinct oncogenic pathways to vulvar squamous cell carcinoma (VSCC). While the incidence of VSCC has remained relatively stable over the last three decades, the incidence of VIN has increased. VIN of usual type (uVIN) is human papillomavirus (HPV)-driven, affects younger women and is a multicentric disease. In contrast, VIN of differentiated type (dVIN) occurs in post-menopausal women and develops independent of HPV infection. dVIN often arises in a background of lichen sclerosus and chronic inflammatory dermatoses. Although isolated dVIN is significantly less common than uVIN, dVIN bears a greater risk for malignant transformation to VSCC and progresses over a shorter time interval. On histological examination, uVIN displays conspicuous architectural and cytological abnormalities, while the morphological features that characterise dVIN are much more subtle and raise a wide differential diagnosis. On the molecular level, dVIN is characterised by a higher number of somatic mutations, particularly in TP53. Here we review the classification, epidemiology, clinical features, histomorphology, ancillary markers and molecular genetics of both types of VIN, and discuss the morphological challenges faced by pathologists in interpreting these lesions.

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“…In 1961, 2 distinct types of carcinoma in situ were recognized, a simplex type and Bowenoid type. 13 In 1976, the ISSVD terminology committee published the "new nomenclature for vulvar disease -histopathological classification of vulvar dystrophies." 8 It consisted of vulvar dystrophies, vulvar atypia (with or without dystrophy), Paget disease of the vulva, and squamous cell carcinoma in situ.…”

Section: A Historic Perspectivementioning

confidence: 99%

The 2015 International Society for the Study of Vulvovaginal Disease (ISSVD) Terminology of Vulvar Squamous Intraepithelial Lesions

Bornstein

Bogliatto

Haefner

et al. 2016

Obstetrics & Gynecology

109

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Intraepithelial and infiltrative carcinoma of vulva: Bowen's type

Cited by 93 publications

References 11 publications

The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: Background and Consensus Recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology

The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: Background and Consensus Recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology

Squamous precursor lesions of the vulva: current classification and diagnostic challenges

The 2015 International Society for the Study of Vulvovaginal Disease (ISSVD) Terminology of Vulvar Squamous Intraepithelial Lesions

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