Intraembryonic hematopoietic cell migration during vertebrate development.

Detrich, H. William; Kieran, Mark W.; Chan, Felix Hon-Wai; Barone, Leesa M.; Yee, Karen O.; Rundstadler, J A; Pratt, Stephen J.; Ransom, David G.; Zon, Leonard I.

doi:10.1073/pnas.92.23.10713

Cited by 554 publications

(396 citation statements)

References 31 publications

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“…The first unambiguous marker of erythroid commitment is the transcription factor gata1. 40 Whole-mount ISH and QPCR analysis on zDL1b-injected embryos revealed complete loss of gata1 (Figure 8b and c), demonstrating that hematopoietic cells become sensitive to zDL1b-mediated apoptosis only as erythroid differentiation begins. zDL1b did not affect expression of the myeloid-specific markers draculin (not shown), pu.1 (Figure 8b), or L-plastin (Figure 8c) in either the ICM or the rostral blood island (RBI).…”

Section: Zdl1b-induced Icm Apoptosis Is Limited To the Erythroid Lineagementioning

confidence: 97%

Delineation of the cell-extrinsic apoptosis pathway in the zebrafish

et al. 2006

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The mammalian extrinsic apoptosis pathway is triggered by Fas ligand (FasL) and Apo2 ligand/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL). Ligand binding to cognate receptors activates initiator caspases directly in a death-inducing signaling complex. In Drosophila, TNF ligand binding activates initiator caspases indirectly, through JNK. We characterized the extrinsic pathway in zebrafish to determine how it operates in a nonmammalian vertebrate. We identified homologs of FasL and Apo2L/TRAIL, their receptors, and other components of the cell death machinery. Studies with three Apo2L/TRAIL homologs demonstrated that they bind the receptors zHDR (previously linked to hematopoiesis) and ovarian TNFR (zOTR). Ectopic expression of these ligands during embryogenesis induced apoptosis in erythroblasts and notochord cells. Inhibition of zHDR, zOTR, the adaptor zFADD, or caspase-8-like proteases blocked ligand-induced apoptosis, as did antiapoptotic Bcl-2 family members. Thus, the extrinsic apoptosis pathway in zebrafish closely resembles its mammalian counterpart and cooperates with the intrinsic pathway to trigger tissue-specific apoptosis during embryogenesis in response to ectopic Apo2L/TRAIL expression.

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Section: Zdl1b-induced Icm Apoptosis Is Limited To the Erythroid Lineagementioning

confidence: 97%

Delineation of the cell-extrinsic apoptosis pathway in the zebrafish

et al. 2006

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“…As diagnostic markers, we used genes expressed at different dorsalventral values along the mesoderm at these stages (listed from the most dorsally expressed to the most ventrally expressed): no tail (ntl; Schulte-Merker et al, 1992), myoD (Weinberg et al, 1996), snail (Hammerschmidt and Nusslein-Volhard, 1993;Thisse et al, 1993), pax2 (Krauss et al, 1991;Puschel et al, 1992;Odenthal and Nusslein-Volhard, 1998;Lekven et al, 2001), gata1 and bmp4 (Detrich et al, 1995;Nikaido et al, 1997;Fig. 2, and data not shown).…”

Section: Expansion Of the Ventroposterior Region And Organization Of mentioning

confidence: 99%

“…The probes used included as follows: no tail (ntl; Schulte-Merker et al, 1992), myoD (Weinberg et al, 1996), snail (Hammerschmidt and Nusslein-Volhard, 1993;Thisse et al, 1993), pax2 (Krauss et al, 1991;Puschel et al, 1992), gata1 (Detrich et al, 1995), bmp2 (Nikaido et al, 1997), bmp4 (Nikaido et al, 1997), and zangptl2 (Kubota et al, 2005b).…”

Section: In Situ Hybridizationsmentioning

confidence: 99%

Analysis of axis induction mutant embryos reveals morphogenetic events associated with zebrafish yolk extension formation

Gingerich

Lindeman

Putiri

et al. 2006

Developmental Dynamics

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We analyze patterning and morphogenetic events during somitogenesis in hecate mutant embryos, which exhibit early axis induction defects. The posterior region, in the absence of a dorsal axis, is capable of forming organized gene expression patterns. The aberrant morphogenesis of mutant embryos is associated with anteriorly directed cell movements, underlying the enveloping layer, from the posterior region. In both wild-type and mutant embryos, these changes result in an accumulation of cells, whose location correlates with a constriction in the posterior yolk cell, which in the wild-type corresponds to the yolk extension. The region encompassing the constriction corresponds to a region of expression of zangptl2 in the yolk syncytial layer, which expands anteriorly together with the anteriorly migrating tail bud-derived cell population.

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“…During fetal life, hematopoietic stem cells (HSC) arise from 2 areas-the dorsal and ventral mesenchyme in an area near the developing aorta known as the intermediate cell mass 118 and migrate intraembryonically to the yolk sac and fetal liver, and then to the bone marrow. 119,120 In the mouse, the liver functions as a hematopoietic organ until about the time of birth, 121,122 and is considered a site of the early differentiation of B cells.…”

Section: Bone Marrow Cells In the Livermentioning

confidence: 99%

Heterogeneity and plasticity of hepatocyte lineage cells

2001

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It is hypothesized that the liver has 3 levels of cells in the hepatic lineage that respond to injury or carcinogenesis: 1) the mature hepatocyte, which responds to partial hepatectomy (PH), to centrolobular injury, such as that induced by carbon tetrachloride (CCl 4 ), and to dimethylnitrosamine (DEN) hepatocarcinogenesis; 2) the ductular "bipolar" progenitor cell, which responds to centrolobular injury when the proliferation of hepatocytes is inhibited, and to N-2-acetylaminofluorene (AAF) hepatocarcinogenesis; and 3) the putative periductular stem cell, which responds to periportal injury, such as induced by allyl alcohol and to choline-deficiency models of hepatocarcinogenesis. Hepatocytes are numerous, respond rapidly by 1 or 2 cell cycles, but can only produce other hepatocytes. The ductular progenitor cells are less numerous, may proliferate for longer times than hepatocytes, and are generally considered "bipolar," i. The restitutive response of the liver to different injuries involves proliferation of cells at different levels in the liver lineage. The hypothesis presented by this review is that, similar to other organ systems, the cellular lineage of the liver consists of stem cells, precursor cells (transit-amplifying cells), and mature cells. It is also proposed that there are 2 origins of stem cells in the liver: endogenous and exogenous. 1

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Intraembryonic hematopoietic cell migration during vertebrate development.

Cited by 554 publications

References 31 publications

Delineation of the cell-extrinsic apoptosis pathway in the zebrafish

Delineation of the cell-extrinsic apoptosis pathway in the zebrafish

Analysis of axis induction mutant embryos reveals morphogenetic events associated with zebrafish yolk extension formation

Heterogeneity and plasticity of hepatocyte lineage cells

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