Intradural cranial chordoma

Clinical and Pathological Features of Intradural Retroclival Chordoma

“…Previous reports (1, 3, 6, 13) considered that the prognosis of intradural intracranial chordoma was considerably more favorable than that of conventional skull base chordoma, with only one case of recurrence and another of metastasis (5,6). However, intradural chordoma patients included in this series could be divided into two distinct prognosis types.…”

“…Chordomas that develop primarily under the intracranial dura mater are very rare. There have been only 20 case reports in the English literature and no case reports in the Chinese literature (5,6,13). During a period of 5 years, between January 2006 and June 2011, six patients with intradural retroclival chordoma were treated in the Skull Base Ward of Beijing Tiantan Hospital Neurosurgery Center.…”

Benign Notochordal Lesions of the Posterior Clivus: Retrospective Review of Prevalence and Imaging Characteristics

“…There are case reports of EP with a high Mib-1 proliferation index 15 or larger than 2 cm 9 as well as reports of chordoma smaller than 2 cm, 10, 13 with a low Mib-1 proliferation index, 8,16 or no associated bone involvement. 2,8,[17][18][19] Since EP and chordoma both derive from embryonic notochordal cells, share common ultrastructural characteristics as well as cell surface markers, and contain the same physaliphorous cells, [20][21][22] no distinguishing and specific pathologic marker is currently available. EP and chordoma are so similar on pathologic analysis that notochord remnant lesions may often be given an erroneous pathologic diagnosis of chordoma.…”

“…Case reports of symptomatic EP have been described 9,12,15,[23][24][25][26] and a less aggressive intradural variant of chordoma has been found in asymptomatic patients. 8,[17][18][19][27][28][29][30][31][32] These reports highlight the limited prognostic value of clinical features in predicting the aggressiveness of retroclival notochord lesions. Since reliance on clinical features and pathologic analysis for diagnosis is fraught with uncertainty, the imaging evaluation of these lesions is critical.…”

Intradural chordoma mimicking a lateral sphenoid wing meningioma: a

“…Therefore, the radiation therapy should not be applied directly after surgery to avoid overtreatment [19]. However, two cases of intradural chordoma with a more aggressive nature have recently been described [12]. Although intradural chordomas are generally benign, long-term follow-up of these patients has only been described for two cases; thus, prolonged close observation is essential [7,9,17].…”