Intraductal oncocytic papillary carcinoma with invasion arising from the accessory pancreatic duct

Nobukawa, Bunsei; Suda, Koichi; Suyama, Masafumi; Ariyama, Joe; Beppu, Tomoo; Futagawa, Shunji

doi:10.1016/s0016-5107(99)70180-x

Cited by 13 publications

(18 citation statements)

References 5 publications

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“…Computed tomography, magnetic resonance cholangiopancreatography, and endoscopic retrograde pancreatography performed in IOPN‐P may reveal a cystic mass or cystic dilatation of pancreatic duct or solid mass within pancreatic parenchyma [2, 30, 32, 36, 37]. Sometimes mural nodules within a cyst may be visualized [36].…”

Section: Resultsmentioning

confidence: 99%

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Intraductal oncocytic papillary neoplasms of the pancreas and bile ducts: a description of five new cases and review based on a systematic survey of the literature

Liszka

Pająk

Zielińska-Pająk

et al. 2010

J Hepato Biliary Pancreat

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Background Intraductal oncocytic papillary neoplasms (IOPN) are rare tumors of the pancreatic and biliary ductal system. It is not absolutely clear if the molecular and clinicopathologic characteristics of IOPN differ significantly from other related lesions, namely intraductal papillary mucinous neoplasms (IPMN). Therefore it is not clear if it is reasonable to consider IOPN as a separate diagnostic and clinical entity. Methods In order to describe the clinicopathologic characteristics of IOPN and to compare them with the IPMN profile, we performed a systematic review of the literature and additionally studied five previously unreported IOPN cases. Results IOPN differ from IPMN by lack of K-ras gene mutations in all studied cases. Several differences in the clinical and biological profile between IOPN and IPMN exist, but they are of quantitative rather than of qualitative nature. Additionally, pancreaticobiliary or gastric-foveolar IPMN components may coexist with IOPN component within a single lesion, which suggests at least a partial relation of the pathogenetic pathways of IPMN and IOPN. Importantly, the pathogenesis of accumulation of mitochondria and oxyphilic appearance of IOPN remains unknown. Conclusions At present, there are no reliable criteria other than histopathological picture and K-ras gene status to differentiate IOPN from IPMN. In particular, no clear differences in optimal treatment options and prognosis between these tumors are known. Further studies are needed to clarify the biology of IOPN and to establish their position in clinicopathologic classifications of pancreatic tumors.

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Section: Resultsmentioning

confidence: 99%

“…In some cases of IOPN‐P, the mucus or the neoplasm itself extends from the orifice of the papilla to the duodenal lumen [30, 32]. Presence of mucin within the bile duct may be documented during endoscopic retrograde cholangiography in patients with IOPN‐B [18].…”

Section: Resultsmentioning

confidence: 99%

Intraductal oncocytic papillary neoplasms of the pancreas and bile ducts: a description of five new cases and review based on a systematic survey of the literature

Liszka

Pająk

Zielińska-Pająk

et al. 2010

J Hepato Biliary Pancreat

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“…Intraductal oncocytic papillary neoplasms (IOPNs) are relatively large (mean of 6.0 cm) 1 4 39. Grossly, they demonstrate marked cystic dilatation of the ducts, which contain soft red-brown nodular luminal masses.…”

Section: Anatomical Classificationmentioning

confidence: 99%

Intraductal papillary mucinous neoplasms of the pancreas: clinical and pathological features and diagnostic approach

Katabi

Klimstra

2008

J Clin Pathol

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Pancreatic intraductal papillary mucinous neoplasms (IPMNs) are mucin-producing neoplasms with a frequent papillary architecture that arise within the pancreatic ducts and are increasingly being recognised. Because they exhibit a spectrum of dysplasia ranging from low grade to high grade and may also have associated invasive carcinoma, and because they are clinically detectable, they are now intensively studied. There is marked overlap between IPMNs and pancreatic intraepithelial neoplasia (PanIN), such that the distinction between these two lesions is nearly impossible in certain cases. In addition, IPMNs sometimes can be confused with other primary cystic lesions of the pancreas. As a result, the correct diagnosis of IPMN can be challenging. This review addresses the clinical and pathological features of IPMNs, emphasising their diagnostic criteria, differential diagnosis and biological behaviour. Problematic issues in the pathological evaluation of IPMNs are discussed.

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“…Of the total 14 patients reported in the literature, recurrence was noted in 1, metastases developed in 1, 3 died postoperatively, 1 died of other causes, and 8 were alive with no evidence of disease (Table 1). [9][10][11] However, there are insufficient data in the literature to determine the clinical course of intraductal oncocytic papillary neoplasm, although the biological behavior of this tumor seems to be better than that of ductal carcinoma. We recently described the clinicodiagnostic features of malignant and benign intraductal papillary tumors of the pancreas to assist us in the selection of appropriate treatment.…”

Section: Discussionmentioning

confidence: 99%

Intraductal Oncocytic Papillary Neoplasm of the Pancreas with Celiac Artery Compression Syndrome and a Jejunal Artery Aneurysm: Report of a Case

et al. 2005

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A 79-year-old woman presented with epigastralgia, and computed tomography showed a 3-cm multiloculated mass with a mural nodule in the head of the pancreas. Arteriography showed stenosis of the celiac artery and a saccular aneurysm, arising from the first jejunal artery. We made a preoperative diagnosis of intraductal papillary adenocarcinoma of the pancreatic head and performed a laparotomy. Transection of the median arcuate ligament failed to restore adequate hepatic blood flow, necessitating construction of celiac vascularization, achieved by a gastroduodenal to jejunal artery anastomosis. After ligation of the jejunal artery aneurysm, we performed a pylorus-preserving pancreaticoduodenectomy. Microscopically, the tumor had papillary intracystic growth, and was lined by plump cells with abundant eosinophilic cytoplasm, consistent with a diagnosis of intraductal oncocytic papillary neoplasm. We discuss this recently recognized entity of papillary neoplasm of the pancreas, and the importance of managing hepatic blood flow during pancreaticoduodenectomy in celiac artery compression syndrome.

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Intraductal oncocytic papillary carcinoma with invasion arising from the accessory pancreatic duct

Cited by 13 publications

References 5 publications

Intraductal oncocytic papillary neoplasms of the pancreas and bile ducts: a description of five new cases and review based on a systematic survey of the literature

Intraductal oncocytic papillary neoplasms of the pancreas and bile ducts: a description of five new cases and review based on a systematic survey of the literature

Intraductal papillary mucinous neoplasms of the pancreas: clinical and pathological features and diagnostic approach

Intraductal Oncocytic Papillary Neoplasm of the Pancreas with Celiac Artery Compression Syndrome and a Jejunal Artery Aneurysm: Report of a Case

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