Intradiscal Injection of Fibrin Sealant for the Treatment of Symptomatic Lumbar Internal Disc Disruption: Results of a Prospective Multicenter Pilot Study with 24-Month Follow-Up

Yin, Way; Pauza, Kevin; Olan, Wayne J.; Doerzbacher, Jeff F.; Thorne, K.

doi:10.1111/pme.12249

Cited by 43 publications

(55 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The patients were explained about the meanings of the figures from 0 to 10 placed on a 10 cm scale. They were asked to show on the scale the numeric value that best described their pain (21,27,28,30).…”

Section: █ Materials and Methodsmentioning

confidence: 99%

“…Higher total scores indicate a higher level of disability. The maximum score is 50 points; 31-50 points was considered as severe, 11-31 as moderate and 1-10 as mild disability (1,22,27,28,30 6. Insomnia Severity Index (ISI): Developed to assess insomnia severity, this is a measurement instrument having high validity and reliability.…”

Section: █ Materials and Methodsmentioning

confidence: 99%

“…The score obtainable from the scale range between 0 and 28. Based on the ratings of the individuals and their partners, ISI is used to measure difficulty in falling asleep, difficulty in staying asleep, problems waking up too early, satisfaction with sleeping pattern, interference with daily functioning, noticeability of sleep-related impairments, and level of stress caused by the problem (18,20,28,30 (Figure 1). After being read to a computer, the recorded data are analyzed on an actigraphy program ( Figure 2).…”

Section: █ Materials and Methodsmentioning

confidence: 99%

“…We obtained a positive increase in the correlation coefficient and statistically significant recovery and quality of life outcomes in both the subjective and objective parameters particularly at the end of postoperative first month when compared with the preoperative values. This suggested that many factors, such as patient anxiety, the type of surgery, the method of anesthesia, the intraoperative pharmacological drugs, the duration of the surgery, and the care services provided to the patient, contribute to the improvement in the postoperative sleep quality (9,15,19,30).…”

Section: █ Conclusionmentioning

confidence: 99%

See 3 more Smart Citations

A study made by using actigraphy regarding the effects on sleep of cervical disk herniation surgery

Samancioglu

Akıncı²,

Osun³

et al. 2015

Turkish Neurosurgery

View full text Add to dashboard Cite

consulting a physician in these patients. Sleep disorders are in the second place after brachialgia with a ratio of 64% (5,12,24,27).Sleep disorders are frequently seen in patients with chronic low back pain (17). In another study, pain was shown to be the most important factor impairing quality of sleep (23). Other studies demonstrated a significant relationship between the severity of pain and the impairment in sleep quality. It has been also shown that quality of sleep improves after the treatments focusing on the cause of pain (5,6).In addition to chronic pain syndromes, there are a lot of studies on sleep disorders in patients who underwent open heart surgery, major abdominal surgery and thoracic surgery which were targeted to the disease underlying the pain (29). In the █ INTRODUCTION C ervical disc herniation (CDH) is characterized by compression of the motor and sensory tracts of cervical nerve roots (radiculopathy) and/or compression of the motor and sensory tracts of the long pathways in the spinal cord (myelopathy) as a result of degenerative events in the cervical vertebrae. An intractable and severe pain radiating from the neck down to the arm (brachialgia) and progressive neurological deficits associated with radiculopathy and/or myelopathy findings in cervical magnetic resonance imaging (MRI) are the major surgical indications in patients with CDH. The surgical procedure in CDH is at the same time a surgical procedure for pain relief. Brachialgia associated with radiculopathy and myelopathy is the main reason for AIm: To analyze the relationship between the severity of pain and sleep disorder using wrist actigraphy in patients with cervical disc herniation (CDH). mATERIAl and mEThODS:Fifty patients with the diagnosis of CDH underwent subjective tests and actigraphic analysis in preoperative period, and at the end of postoperative first week and postoperative first month. The data of the subjective tests and actigraphic analysis were compared. RESUlTS:There was a strong and statistically significant negative correlation between the subjective tests of Visual Analog Scale (VAS) for Pain 0-1-2 and the objective parameters of Sleep Onset Latency (SOL) 0-1-2 (rs= -0.798, p=0.009 -rs= -0.832, p=0.006 -rs=-0.710, p=0.004). There was a positive correlation between the subjective tests of VAS for Pain 0-1-2 and the objective parameters of Sleep Efficiency (SEF) 0-1-2 (rs=0.721, p=0.006 -rs= 0.768, p=0.001 -rs= 0.748, p=0.001).CONClUSION: Actigraphy may be used for the evaluation of cervical disc surgery, as an alternative and objective test for sleep disorders.

show abstract

Section: █ Materials and Methodsmentioning

confidence: 99%

Section: █ Materials and Methodsmentioning

confidence: 99%

Section: █ Materials and Methodsmentioning

confidence: 99%

Section: █ Conclusionmentioning

confidence: 99%

See 2 more Smart Citations

A study made by using actigraphy regarding the effects on sleep of cervical disk herniation surgery

Samancioglu

Akıncı²,

Osun³

et al. 2015

Turkish Neurosurgery

View full text Add to dashboard Cite

show abstract

“…Beyond IVD allografting, the number of biomaterial‐based therapy for IVD degeneration in humans is very limited. The clinical outcomes of intradiscal injection of fibrin sealant in 15 patients with lumbar discogenic pain was reported: except for two cases of low back muscle spasm and one case of discitis, 87% of the patients achieved at least a 30% reduction in low back pain compared with the baseline at the 26‐week primary endpoint (Yin, Pauza, Olan, et al, ). In addition, a collagen sponge was selected as a carrier for bone marrow cells to treat low back pain with favourable outcomes in two cases (Yoshikawa, Ueda, Miyazaki, et al, ).…”

Section: Clinical Application Of Biomaterials For Ivd Degenerationmentioning

confidence: 99%

Biomaterials for intervertebral disc regeneration: Current status and looming challenges

Huang

et al. 2018

J Tissue Eng Regen Med

View full text Add to dashboard Cite

A biomaterial-based strategy is employed to regenerate the degenerated intervertebral disc, which is considered a major generator of neck and back pain. Although encouraging enhancements in the anatomy and kinematics of the degenerative disc have been gained by biomaterials with various formulations in animals, the number of biomaterials tested in humans is rare. At present, most studies that involve the use of newly developed biomaterials focus on regeneration of the degenerative disc, but not pain relief. In this review, we summarise the current state of the art in the field of biomaterial-based regeneration or repair for the nucleus pulposus, annulus fibrosus, and total disc transplantation in animals and humans, and we then provide essential suggestions for the development and clinical translation of biomaterials for disc regeneration. It is important for researchers to consider the commonly neglected issues instead of concentrating solely on biomaterial development and fabrication.

show abstract

Complications of Intradiscal Therapeutic Procedures

Costandi¹,

Prayson²

2022

Complications of Pain‐Relieving Procedures

View full text Add to dashboard Cite

Intradiscal Injection of Fibrin Sealant for the Treatment of Symptomatic Lumbar Internal Disc Disruption: Results of a Prospective Multicenter Pilot Study with 24-Month Follow-Up

Abstract: Intradiscal injection of BIOSTAT BIOLOGX Fibrin Sealant with the Biostat Delivery Device appears safe and may improve pain and function in selected patients with discogenic pain.

Cited by 43 publications

References 81 publications

A study made by using actigraphy regarding the effects on sleep of cervical disk herniation surgery

A study made by using actigraphy regarding the effects on sleep of cervical disk herniation surgery

Biomaterials for intervertebral disc regeneration: Current status and looming challenges

Complications of Intradiscal Therapeutic Procedures

Contact Info

Product

Resources

About