Intradiscal Administration of Osteogenic Protein-1 Increases Intervertebral Disc Height and Proteoglycan Content in the Nucleus Pulposus in Normal Adolescent Rabbits

An, Howard S.; Takegami, Kenji; Kamada, Hiroshi; Nguyen, Cahn; Thonar, Eugene J-M.A.; Singh, Kern; Andersson, Gunnar; Masuda, Koichi

doi:10.1097/01.brs.0000148002.68656.4d

Cited by 209 publications

(131 citation statements)

References 30 publications

(19 reference statements)

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“…BMP-2 and BMP-7 (osteogenic protein 1) act to increase proteoglycan production, specifically aggrecan and collagen types I and II in AF and NP cells [11,37,47]. Local injection of degenerative discs with BMP-2 and BMP-7 has been reported to maintain disc height and increase production of proteoglycans in both rat and rabbit models [3,31,34,41,58]. Despite successful demonstration of increased proteoglycan and collagen content, BMPs also cause ossification of the annulus and aberrant bone formation [29,35].…”

Section: Protein-based Therapiesmentioning

confidence: 99%

Molecular Basis of Intervertebral Disc Degeneration and Herniations: What Are the Important Translational Questions?

Kadow

Sowa

et al. 2015

Clinical Orthopaedics &Amp; Related Research

217

197

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Background Intervertebral disc degeneration is a common condition with few inexpensive and effective modes of treatment, but current investigations seek to clarify the underlying process and offer new treatment options. It will be important for physicians to understand the molecular basis for the pathology and how it translates to developing clinical treatments for disc degeneration. In this review, we sought to summarize for clinicians what is known about the molecular processes that causes disc degeneration.

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Section: Protein-based Therapiesmentioning

confidence: 99%

Molecular Basis of Intervertebral Disc Degeneration and Herniations: What Are the Important Translational Questions?

Kadow

Sowa

et al. 2015

Clinical Orthopaedics &Amp; Related Research

217

197

View full text Add to dashboard Cite

show abstract

“…For instance, the use of SOX9, TGFbeta1, TIMP1, and BMP2 has been shown to preserve the architecture of disc tissue and/or increase collagen and proteoglycan synthesis through adenovirus-mediated gene therapy [48,53,83]. On the other hand, treating disc cells or direct intradiscal injection with growth factors OP-1(BMP-7), GDF-5, or intradiscal delivery of adenovirus coupled LMP-1 expression vector can also elevate the proteoglycan level [3,30,40,77,89]. Cell therapy is an alternative approach, and the regenerative effects of transplantation of autologous cells, such as mesenchymal stem cells [12,65,66,90], nucleus pulposus cells [50,52,84], and cartilaginous chondrocytes [18,20] into the IVD, have been demonstrated.…”

Section: Emerging Biological Approaches In Treating Ivd Degenerationmentioning

confidence: 99%

Regeneration of intervertebral disc by mesenchymal stem cells: potentials, limitations, and future direction

2006

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Over the past few years, substantial progress has been made in the field of stem cell regeneration of the intervertebral disc. Autogenic mesenchymal stem cells in animal models can arrest intervertebral disc degeneration or even partially regenerate it and the effect is suggested to be dependent on the severity of degeneration. Mesenchymal stem cells (MSCs) are able to escape alloantigen recognition which is an advantage for allogenic transplantation. A number of injectable scaffolds have been described and various methods to pre-modulate MSCs' activity have been tested. In future, work will need to address the use of mesenchymal stem cells in large animal models and the fate of the implanted mesenchymal stem cells, particularly in the long term, in animals. This review examines the state-of-the-art in the field of stem cell regeneration of the intervertebral disc, and critically discusses, with scientific support, the issues involved, before stem cells could be used in human subjects. [79,81]. In the development of organism, the single totipotent cell after fertilization divides and specializes into pluripotent cells, such as embryonic stem cells that are necessary for fetal development. The pluripotent cells then further specialize into multipotent cells that commit into lineages with tissue-specific functions. Cells have been successfully identified in or isolated from embryonic [70], fetal [34, 73], or adult tissues [45] and demonstrated to have stem cell-like properties in vitro and in vivo. The maintenance, survival and activity of these stem cells is suggested to be dependent on the special micro-environmental niche [45], such that uncommitted pluripotent stem cells can be induced to differentiate to form a particular cell type by the nature of the environment. Additionally, the pluripotency of stem cells depends on the source, the method of isolation, and conditions of ex-vivo cell processing.

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“…Disc height and disc height index measurements were done as per method of Lu et al modified by An et al in which the disc height was calculated by an average of measurements obtained from the anterior, middle and posterior portions of the Intervertebral Disc (IVD) and this value was divided by the average of sum of adjacent vertebral body heights to calculate the Disc Height Index (DHI) [1,17]. This helped in avoiding the errors of magnification and positioning while taking X-rays.…”

Section: Patient Populationmentioning

confidence: 99%

Modified transcorporeal anterior cervical microforaminotomy for cervical radiculopathy: a technical note and early results

et al. 2007

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A prospective analysis of the first twenty patients operated for cervical radiculopathy by a new modification of transcorporeal anterior cervical foraminotomy technique. To evaluate early results of a functional disc surgery in which decompression for the cervical radiculopathy is done by drilling a hole in the upper vertebral body and most of the disc tissue is preserved. Earlier approaches to cervical disc surgery either advocated simple discectomy or discectomy with fusion, ultimately leading to loss of motion segment. Posterior foraminotomy does not address the more common anterior lesion. Twenty patients suffering from cervical radiculopathy not responding to conservative treatment were chosen for the new technique. Upper vertebral transcorporeal foraminotomy was performed with the modified technique in all the patients. All the patients experienced immediate/early relief of symptoms. No complications of vertebral artery injury, Horner's syndrome or recurrent laryngeal nerve palsy were noted. Modified transcorporeal anterior cervical microforaminotomy is an effective treatment for cervical radiculopathy. It avoids unnecessary violation of the disc space and much of the bony stabilizers of the cervical spine. Short-term results of this technique are quite encouraging. Longer-term analysis can help in outlining the true benefits of this technique.

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Intradiscal Administration of Osteogenic Protein-1 Increases Intervertebral Disc Height and Proteoglycan Content in the Nucleus Pulposus in Normal Adolescent Rabbits

Cited by 209 publications

References 30 publications

Molecular Basis of Intervertebral Disc Degeneration and Herniations: What Are the Important Translational Questions?

Molecular Basis of Intervertebral Disc Degeneration and Herniations: What Are the Important Translational Questions?

Regeneration of intervertebral disc by mesenchymal stem cells: potentials, limitations, and future direction

Modified transcorporeal anterior cervical microforaminotomy for cervical radiculopathy: a technical note and early results

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