Intradialytic exercise training reduces oxidative stress and epicardial fat: a pilot study

Wilund, Kenneth R.; Tomayko, Emily J.; Wu, Pei Tzu; Chung, Ho Kyoon; Vallurupalli, Srikanth; Lakshminarayanan, Batlagundu; Fernhall, Bo

doi:10.1093/ndt/gfq106

Cited by 123 publications

(149 citation statements)

References 41 publications

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“…MPI has been proved as a helpful systolic-diastolic index indicating the prognosis of patients who suffered from CVD. 15,16 Lavine et al indicated volume loading reduced MPI as a result of LV ejection time lengthening. But MPI did not changed because of heart rate incrementation or ageing.…”

Section: Discussionmentioning

confidence: 99%

The influence of low calcium dialysate on left ventricular diastolic function in peritoneal dialysis patients

Wang

Wen

et al. 2016

Renal Failure

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Left ventricular (LV) diastolic function was found to be a significant predictor of cardiovascular events and general mortality in dialysis. Studies have indicated that dialysate calcium concentrations were significantly associated with cardiac function. However, the relationship between low calcium dialysate and LV diastolic function has not been clear. The aim of this study was to investigate the influence of low calcium dialysate on cardiac function in peritoneal dialysis (PD) patients. A total of 60 PD patients were enrolled in this study, with a calcium content of the PD solution of 1.25 mmol/L in 30 patients (low-calcium group) and 1.75 mmol/L in 30 patients (standard-calcium group). Standard M-mode and two-dimensional ultrasound measurements were applied to detect the cardiac function. After 12-month follow-up, we found no significant difference in blood pressure, calcium, phosphorus, parathyroid hormone (PTH), etc., between the two groups. Residual renal function (RRF), which is associated with LV cardiac function, was significantly decreased in the standard-calcium group compared with the low-calcium group (5.64 ± 3.23 vs. 9.38 ± 3.17, p ¼ .001). Compared with the low-calcium group, E max (peak early diastolic velocity) and A max (peak late diastolic velocity) were significantly decreased (p < .05), whereas myocardial performance index (MPI) was obviously increased in standard-calcium group (9.69 ± 2.71 vs. 7.75 ± 0.93, p < .05). In conclusion, our data suggest that low calcium dialysate treatment is significantly associated with better LV diastolic function. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

The influence of low calcium dialysate on left ventricular diastolic function in peritoneal dialysis patients

Wang

Wen

et al. 2016

Renal Failure

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“…In 17 patients with mild-to-moderate CKD, aerobic water-based exercise significantly reduced lipid peroxidation products (malondialdehyde and 4-hydroxyalkenals) and increased levels of the antioxidant glutathione compared with a sedentary control group (55). Similarly, intradialytic aerobic training for 4 months reduced thiobarbituric acid reactive substance, a product of lipid peroxidation, by 38% in hemodialysis patients compared with usual care (56). No data currently exist on the effects of resistance ET or combined aerobic/resistance regimens.…”

Section: Osmentioning

confidence: 93%

“…In addition to eNOS activation, ET results in more efficient antioxidative defense mechanisms (e.g., by reducing ROS production [reduction in NAD(P)H expression, less eNOS uncoupling, etc.] and increasing the expression of antioxidative enzymes and ROS scavengers [e.g., glutathione]) (9,55,56). As such, ROS-mediated breakdown of NO is prevented.…”

Section: No Bioavailabilitymentioning

confidence: 99%

“…Also, in the dialysis population, data are inconsistent. After aerobic ET, some RCTs are clearly supportive of a favorable effect on circulating markers of inflammation (64), whereas others are not (28,56,65). In one of the largest RCTs (49 patients), a 12-week program of progressive intradialytic resistance training significantly reduced CRP levels compared with the levels in a sedentary control group (66).…”

Section: Systemic Inflammationmentioning

confidence: 99%

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Vascular Effects of Exercise Training in CKD

Craenenbroeck

Kouidi

et al. 2014

Clinical Journal of the American Society of Nephrology

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Cardiovascular disease remains the main cause of morbidity and mortality in patients with CKD, an observation that cannot be explained by the coexistence of traditional risk factors alone. Recently, other mechanisms, such as alterations in nitric oxide bioavailability, impaired endothelial repair mechanisms, inflammation, and oxidative stress (all characteristic in CKD), have gained much attention as mediators for the increased cardiovascular risk. Regular physical training is a valuable nonpharmacological intervention for primary and secondary prevention of cardiovascular disease. Likewise, the benefits of exercise training on exercise capacity and quality of life are increasingly recognized in patients with CKD. Furthermore, exercise training could also influence potential reversible mechanisms involved in atherosclerosis and arteriosclerosis. After discussing briefly the general concepts of vascular disease in CKD, this review provides an overview of the current evidence for the effects of exercise training at both clinical and preclinical levels. It concludes with some practical considerations on exercise training in this specific patient group.

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“…The patients usually cycle for 10-45 min and progressively resistance is applied to the bicycle wheels [72][73][74][75][76][77][78][79][80][81][82]. Also, resistance exercises have been applied in intradialytic exercise training programs without serious complications and induced beneficial effects on patient's muscular strength [83][84][85][86][87][88][89][90] The exercises sessions occurred at the hemodialysis centers during the first two hours of the hemodialysis treatment (table 4).…”

Section: Effects Of Intradialytic Exercise Programsmentioning

confidence: 99%

Intra-Renal Hemodynamic Changes After Habitual Physical Activity in Patients with Chronic Kidney Disease

Καλτσάτου¹,

Karatzaferi²,

Mitrou³

et al. 2016

CPD

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Intradialytic exercise training reduces oxidative stress and epicardial fat: a pilot study

Abstract: These results suggest that endurance exercise training may improve CVD risk in haemodialysis patients by decreasing novel risk factors including serum oxidative stress, ALP and epicardial fat.

Cited by 123 publications

References 41 publications

The influence of low calcium dialysate on left ventricular diastolic function in peritoneal dialysis patients

The influence of low calcium dialysate on left ventricular diastolic function in peritoneal dialysis patients

Vascular Effects of Exercise Training in CKD

Intra-Renal Hemodynamic Changes After Habitual Physical Activity in Patients with Chronic Kidney Disease

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