Intradialytic complications: a poor prognostic factor among patients with lassa fever with acute kidney injury undergoing hemodialysis

Rafiu, Mojeed; Dada, Samuel Ayokunle; Azubike, Chukwuemeka O; Ahmed, Sulaiman Dazumi; Aigbiremolen, Alphonsus O; Alili, Itohan B; Akhideno, Peter Ehizokhale; Erameh, Cyril; Ifada, Ehinomen Cordilia; Aigbiremolen-Alphonsus, Agnes E; Omonzokpea, Esther; Iraoyah, Kelly O; Okoeguale, Joseph; Ogbaini-Emovon, Ephraim; Okogbenin, Sylvanus; Akpede, George O.; Okokhere, Peter O

doi:10.4103/jesnt.jesnt_26_19

Cited by 2 publications

(1 citation statement)

References 3 publications

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“…HTN is responsible for many cardiovascular diseases and high mortality rates in CKD patients, especially those on hemodialysis. In Egypt, hypertensive nephropathy is considered one of the major causes of the prevalence of dialysis as a renal replacement therapy [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Association Between Renalase Gene Polymorphism (rs2296545) and Hypertension in Egyptian Chronic Kidney Disease Patients

Khater,

Abd EL-Hassib,

Sabry

et al. 2023

Cureus

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Background Renalase gene polymorphisms are associated with an increased risk of essential hypertension, chronic kidney disease (CKD), heart disease, diabetes, and stroke. One of these polymorphisms is a common missense (rs2296545) polymorphism, which was reported to be related to hypertension. The aim of this work was to investigate the possible relation between renalase gene polymorphism (rs2296545) and hypertension in patients with CKD patients. Subjects and methods Ninety patients were included in this case-control study: 30 normotensive CKD patients, 30 hypertensive CKD patients, and 30 apparently healthy controls. Genomic deoxyribonucleic acid (DNA) was extracted from peripheral whole blood, and renalase gene (rs2296545) polymorphism was genotyped in all patients and controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Odds ratios (OR) and their 95% CIs were calculated. Results We found that the CC genotype and the C allele renalase (rs2296545) were statistically associated with the risk of CKD (OR= 9.4; 95%CI 1.2-7.2; P= 0.036) and (OR= 3.78; 95%CI 1.57-9.08; P= 0.003), respectively. There was a statistically significant difference between the hypertensive CKD patients and the controls regarding the CC genotypes and the C allele, (26.7% versus 3.3%, P= 0.018) and (40% versus 11.7%, P< 0.001) for the CC genotype and the C allele, respectively. The mean values of systolic and diastolic blood pressure were higher in the normotensive CKD patients with the CC genotype compared to other genotypes (P= 0.014 and P= 0.022, respectively) and also were higher in hypertensive CKD patients with the CC genotype when compared to other genotypes (P= 0.001 for both). Conclusion This study demonstrated a statistically significant increase in the renalase gene (rs2296545) CC genotype and the C allele in CKD patients, especially hypertensive CKD.

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Section: Discussionmentioning

confidence: 99%

Association Between Renalase Gene Polymorphism (rs2296545) and Hypertension in Egyptian Chronic Kidney Disease Patients

Khater,

Abd EL-Hassib,

Sabry

et al. 2023

Cureus

View full text Add to dashboard Cite

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Association of Hypoalbuminemia and Reversal of Albumin-to-Globulin Ratio with Morbidity Outcome among Hospitalized Lassa Fever Infected Patients at a Dedicated Treatment Center in Ondo state, South-Western Nigeria

et al. 2020

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Background: As of this present moment, there is paucity of data on report concerning the association between hypoalbuminaemia or reversal of albumin-to-globulin ratio and morbidity outcome in Lassa fever (LF) infection as a crucial determinant prognostic-predictor factor for treatment-survival outcome. Aim: This study was designed to determine the association between hypoalbuminaemia, reversal of albumin-to-globulin ratio and morbidity outcome among confirmed LF infected patients. Methodology: This was a descriptive retrospective study involving the assessment of records of confirmed LF infected patients that were managed at the center from November 2018 to October 2019. Results: Out of 83 recruited participants with complete records, 66 (79.5%) had hypoalbuminaemia, 74 (89.2%) had reversal of albumin-to-globulin ratio. A higher mean value of total white blood cell (WBC) count was observed among patients with hypoalbuminaemia (p < 0.0001) and reversal of albumin-to-globulin ratio (p < 0.0001) when compared to patients with normal values, respectively. Also, this study showed statistically significant associations between serum albumin level versus total WBC count (p < 0.0001), acute kidney injury (AKI; p = 0.009), bleeding diathesis (p < 0.0001), and occurrence of pregnancy miscarriage (p < 0.0001). Conclusion: There is a baseline hypoalbuminaemia and reversal of albumin-to-globulin ratio among confirmed LF infected patients. Based on these findings, the serum level of albumin and albumin-to-globulin ratio at presentation may serve as simple early biomarkers to identify patients at high risk for a complicated clinical course of disease. This study also reveals that those hospitalized LF infected patients with hypoalbuminemia and/or reversal of albumin-to-globulin ratio tend to have leucocytosis and experience prolonged duration of illness.

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Intradialytic complications: a poor prognostic factor among patients with lassa fever with acute kidney injury undergoing hemodialysis

Cited by 2 publications

References 3 publications

Association Between Renalase Gene Polymorphism (rs2296545) and Hypertension in Egyptian Chronic Kidney Disease Patients

Association Between Renalase Gene Polymorphism (rs2296545) and Hypertension in Egyptian Chronic Kidney Disease Patients

Association of Hypoalbuminemia and Reversal of Albumin-to-Globulin Ratio with Morbidity Outcome among Hospitalized Lassa Fever Infected Patients at a Dedicated Treatment Center in Ondo state, South-Western Nigeria

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