Intradermal Triamcinolone Acetonide in Localized Lesions

Topical and Intralesional Administration of Triamcinolone Acetonide: Advantages in Dermatologic Therapy

“…Similar results were obtained by intralesional injections in 82 per cent of 23 patients. These findings tend to confirm those of several studies supporting the concept that triamcinolone acetonide is the most active of the available glucocorticoids when administered topically (11, 12, 18).…”

“…Our results with intralesional treatment seem to support those of other investigators (27, 28), namely, that administration of a topically potent corticosteroid by the modern vibrapuncture technique offers the physician an effective means of treating dispersed as well as solitary skin lesions. Standard hypodermic injections have been employed successfuly by a number of investigators (3, 11, 12, 17) but in our study we used them only in the treatment of keloids.…”

“…There is no longer any question about the preferential use of corticosteroids, alone or in combination with antibiotics, in the treatment of various skin diseases (1–28). These agents have proven decisive in many clinical states in which the associated inflammation and pruritus are of compelling importance.…”

Topical Medication in Relation to Skin Physiology

“…Cohen and Baer (1960) found that oral triamcinolone was more effective than methyl prednisolone or prednisolone; others, while agreeing that triamcinolone is a potent drug for systemic treatment of psoriasis, point out that undesirable side effects are common and it is unsuitable for general use (Greenlee and Epstein, 1959). However, effective results from topical medication have been achieved with triamcinolone acetonide in lotion (Crowe, Fitzpatrick, Walker and Olson, 1958) or given into the lesions (Cohen and Baer, 1960;James, 1960;Readett, 1961) and by subdermal infiltration with triamcinolone diacetate (Gerard, 1960). confirmed the observation of Lawrence and Bern (1958) that topical application of vitamin A to mouse tail epidermis causes formation of a granular layer and conversion of "parakeratotic" scales to flexible keratin.…”

New "Inject-Tainer"

“…The dermatoses reported to respond to the local injection of steroids include alopecia areata, alopecia totalis, alopecia universalis, circumscribed neurodermatitis, psoriasis, atopic dermatitis, lichen planus, keloid, nummular eczema, granuloma annulare, erythema annulare centrifugum, dermatitis herpetiformis, pemphigus, and discoid lupus erythematosus. [1][2][3][4][5] In addition to the intralesional injection of lesions such as those listed above, the dermatologist makes use of intracutaneous or subcutaneous injections routinely for the administration of many drugs, infiltration of lesions with local anesthetics prior to biopsy or excision, intradermal testing in allergic conditions, etc. This extensive employment of injections creates several important health problems, as well as many minor ones.…”