Intradermal Nociceptin Elicits Itch-Associated Responses Through Leukotriene B4 in Mice

Andoh, Tsugunoubu; Yageta, Yuichi; Takeshima, Hiroshi; Kuraishi, Yasushi

doi:10.1111/j.0022-202x.2004.22704.x

Cited by 68 publications

(48 citation statements)

References 32 publications

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“…In conjunction with these findings, the above results raise the possibility that leukotriene B 4 is involved in the ESGM-elicited scratching. However, the ESGM-elicited scratching was not affected by the leukotriene B 4 antagonist ONO-4057 at doses that had been shown to suppress scratching induced by intradermal injections of substance P (8) and nociceptin (19). Therefore, the result suggests that leukotriene B 4 is not involved in the ESGM-elicited scratching.…”

Section: Discussionmentioning

confidence: 87%

“…Dexamethasone inhibits the production of leukotriene B 4 induced by substance P in skin in vivo and cultured keratinocytes in vitro (8). An intradermal injection of leukotriene B 4 at relatively low doses elicits scratching (7), and the leukotriene B 4 antagonist suppresses scratching induced by intradermal injections of substance P and nociceptin (8,19). Azelastine suppresses scratching elicited by ESGM in sensitized mice (5) and by leukotriene B 4 in healthy mice (6).…”

Section: Discussionmentioning

confidence: 99%

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Possible Involvement of 5-Lipoxygenase Metabolite in Itch-Associated Response of Mosquito Allergy in Mice

et al. 2007

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Abstract. This study investigated endogenous mediators involved in mosquito allergyassociated itching in mice. An intradermal injection of an extract of mosquito salivary gland elicited marked scratching in sensitized mice. The 5-lipoxygenase inhibitor zileuton (100 mg / kg), the 5-lipoxygenase activating peptide inhibitor MK-886 (10 mg / kg), and the glucocorticoid betamethasone 17-valerate (3 mg / kg) inhibited the scratching. The scratching was not affected by the cyclooxygenase inhibitors indomethacin and ketoprofen, the TP prostanoid receptor antagonist SQ-29548, the leukotriene B 4 antagonist ONO-4057, the cysteinyl leukotriene antagonist pranlucast, the leukotriene D 4 antagonist MK-571, the platelet-activating factor antagonist CV-3988, the nitric oxide synthase inhibitor N G -nitro-L-arginine methyl ester, the H 2 histamine-receptor antagonist cimetidine, the H 1 histamine-receptor antagonist terfenadine plus cimetidine, and cypoheptadine that blocks the 5-HT 1/ 2 serotonin receptors. Zileuton (100 mg / kg) inhibited the increased activity of the cutaneous nerve branch induced by an intradermal injection of the extract, suggesting the peripheral action. Zileuton and MK-886 (10 and 100 µM) did not affect high K + -induced increase in intracellular Ca 2+ concentration in cultured dorsal root ganglion neurons. The results suggest that 5-lipoxygenase metabolite(s) other than leukotriene B 4 and cysteinyl leukotrienes are involved in mosquito allergy-associated itching.Keywords: itch of mosquito allergy, 5-lipoxygense metabolite, zileuton, cutaneous nerve branch, dorsal root ganglion neuron

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Possible Involvement of 5-Lipoxygenase Metabolite in Itch-Associated Response of Mosquito Allergy in Mice

et al. 2007

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“…Total RNA was obtained from the pooled DRGs and was used for the determination of ET-receptor mRNA with RT-PCR, as described (19). The sequences of primers used were as follows: ET A endothelin receptor, 5'-aagcctcatgacctcggtcc-3' (sense) and 5'-tctgtgttcatgcaaaggcg-3' (antisense); ET B endothelin receptor, 5'-tgaaggcaagaacactcgcc-3' (sense) and 5'-tggcat gtgaacgcactagg-3' (antisense); β-actin, 5'-tcagaaggactc ctatgtgg-3' (sense) and 5'-tctctttgatgtcacgcacg-3' (antisense).…”

Section: Reverse Transcriptase and Polymerase Chain Reaction (Rt-pcr)mentioning

confidence: 99%

Involvement of Endothelin and ETA Endothelin Receptor in Mechanical Allodynia in Mice Given Orthotopic Melanoma Inoculation

et al. 2008

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Abstract. We investigated whether endothelin (ET) would be involved in skin cancer pain in mice. Orthotopic inoculation of B16-BL6 melanoma cells into the plantar region of the hind paw produced marked mechanical allodynia in C57BL/ 6 mice. Intraplantar injections of the ET Areceptor antagonist BQ-123 (0.3 -3 nmol/ site), but not the ET B -receptor antagonist BQ-788 (1 and 3 nmol/ site), inhibited mechanical allodynia in mice with grown melanoma. In naive mice, an intraplantar injection of tumor extract (1 and 3 mg/ site), which was prepared from the grown melanoma in the paw, produced mechanical allodynia, which was inhibited by BQ-123 and BQ-788 at doses of 3 and 10 nmol/ site. An intraplantar injection of ET-1 (1 and 10 pmol/ site) elicited licking behavior, which was increased in the melanoma-bearing hind paw. BQ-123 (3 and 10 nmol/ site) inhibited licking induced by ET-1 (10 pmol/ site). The level of mRNA of ET A , but not ET B , receptor, was significantly increased in the dorsal root ganglia on the inoculated side. Cultured B16-BL6 cells contained ET, and the melanoma mass increased the concentration of ET as it grew bigger. These results suggest that ET-1 and ET A receptor are at least partly involved in the induction of pain induced by melanoma cell inoculation.

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“…A series of the following movements was counted as one bout of scratching; stretching either hind paw toward the injection site, leaning the head toward the hind paw, scratching several times for about 1 s, and moving the hind paw down to the mouth. 11,12) Statistical Analysis All data were presented as meansϮS.E.M. Statistical significance was analyzed using Student's t-test or Bonferroni method.…”

Section: Animalsmentioning

confidence: 99%

Effects of Topical Application of Tacrolimus on Acute Itch-Associated Responses in Mice

Nakano

Andoh

Tayama

et al. 2008

Biological & Pharmaceutical Bulletin

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Tacrolimus is a macrolide immunosuppressant derived from Streptomyces tsukubaensis. It binds to FK506-binding protein (FKBP) 12, a member of the immunophilin family, to produce many biological actions.1) Repeated topical application of tacrolimus is effective against pruritus of atopic dermatitis, 2,3) and the decrease of pruritus may be mainly due to the reduction of dermatitis and cytokine production.1) This view is supported by the finding that repeated topical application of tacrolimus suppresses increases in CD4 ϩ T cells, mast cells, eosinophils, interleukin-4, interleukin-5, and immunoglobulin E in the skin of mice with atopy-like chronic dermatitis. 4) In contrast, although repeated topical application of tacrolimus inhibits scratching in mice with allergic dermatitis, it does not suppress increases in lymphocytes, eosinophils, mast cells and messenger ribonucleic acid (mRNA) of interleukin-5 in the affected skin and serum concentration of immunoglobulin E.5) It suppresses increases in mRNA for interleukin-4 and interferon-g, which are also suppressed by glucocorticoid at a topical dose that does not affect scratching.5) Pruritus of primary biliary cirrhosis, a non-allergic and non-inflammatory disease, was reported to be inhibited by repeated topical application of tacrolimus to the areas affected by the pruritus. 6) These findings raise the possibility that immunosuppressive action is not an exclusive mechanism of the anti-pruritic effect of tacrolimus.Topical application of tacrolimus causes skin burning and pruritus to the application site in about a quarter of patients. 7)Tacrolimus produces the transient increase of discharge in cutaneous C-fibers in the skin-nerve preparation. 8)Tacrolimus also increases intracellular Ca 2ϩ concentration in a small population of sensory neurons in the primary culture and most of tacrolimus-sensitive neurons respond to capsaicin.8) Capsaicin-sensitive sensory nerves may be involved in signaling of itch as well as pain.9) These findings suggest that tacrolimus directly acts on the primary sensory nerve, some of which are involved in itch and pain signaling.It is possible that these acute actions of tacrolimus affect itch sensation. The present study was conducted to determine whether topical application of tacrolimus would produce an acute anti-pruritic effect. MATERIALS AND METHODS AnimalsMale ICR mice (Japan SLC, Shizuoka) of 5 weeks old at the start of experiments were used. They were housed six per cage under controlled temperature (22Ϯ1°C) and humidity (55Ϯ10%). The room was lighted from 7:00 a.m. to 7:00 p.m. Food and water were available ad libitum. The study was approved by the Committee for Animal Experiments at University of Toyama.Materials Histamine (Sigma, St. Louis, MO, U.S.A.), serotonin hydrochloride (Sigma), substance P (Peptide Institute, Osaka), and the protease-activated receptor-2 agonist SLIGRL-NH 2 , synthesized by LJ, were dissolved in saline. These compounds were injected intradermally in a volume of 50 ml into the rostral part of the mouse ...

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Intradermal Nociceptin Elicits Itch-Associated Responses Through Leukotriene B4 in Mice

Cited by 68 publications

References 32 publications

Possible Involvement of 5-Lipoxygenase Metabolite in Itch-Associated Response of Mosquito Allergy in Mice

Possible Involvement of 5-Lipoxygenase Metabolite in Itch-Associated Response of Mosquito Allergy in Mice

Involvement of Endothelin and ETA Endothelin Receptor in Mechanical Allodynia in Mice Given Orthotopic Melanoma Inoculation

Effects of Topical Application of Tacrolimus on Acute Itch-Associated Responses in Mice

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