Intradermal Immunization

Abstract

Many attempts have been made to immunize against typhoid fever by methods other than the usual subcutaneous administration of vaccine. Thus Moor and Brown1 and Crimm and Short2 reported that vaccination by the oral route gave rise to concentrations of agglutinins in the blood serum which were as high as those obtained by the subcutaneous method. Downs and Bond,3 however, found that administration of typhoid vaccine by the oral route produced agglutinins in lower titers than those produced by subcutaneous injections.In a previous report 4 we showed the efficacy of intradermal immunization against scarlet fever. In 1932 Tuft and his associates 5 recommended intradermal immunization against typhoid fever. Siler and Dunham6 found that revaccination against typhoid fever by intracutaneous injection produced a satisfactory immunologic response. Tuft 7 recently showed, by means of mouse protection tests, that vaccination From the Children'