2009
DOI: 10.1007/s00262-009-0725-4
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Intradermal DNA electroporation induces survivin-specific CTLs, suppresses angiogenesis and confers protection against mouse melanoma

Abstract: Survivin is an intracellular tumor-associated antigen that is broadly expressed in a large variety of tumors and also in tumor associated endothelial cells but mostly absent in differentiated tissues. Naked DNA vaccines targeting survivin have been shown to induce T cell as well as humoral immune responses in mice. However, the lack of epitope-specific CD8+ T cell detection and modest tumor protection observed highlight the need for further improvements to develop effective survivin DNA vaccination approaches.… Show more

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Cited by 51 publications
(36 citation statements)
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“…WH-neoepitope-TNE but not G-actin-neoepitope-TNE significantly suppressed tumor growth and enhanced survival ( Figure 7, A and B) and induced strong IFN-γ immunity to pooled B16 epitopes and to the universal tumor antigen, survivin (ref. 42 and Figure 7C). Immunogenicity and antitumor effects of the WH-neoepitope-TNE vaccine were Th cell-dependent, as the significant tumor suppression observed with WH-TNE was lost if CD4 + T cells were depleted during treatment ( Figure 7D).…”
Section: Cific Cd4mentioning
confidence: 99%
“…WH-neoepitope-TNE but not G-actin-neoepitope-TNE significantly suppressed tumor growth and enhanced survival ( Figure 7, A and B) and induced strong IFN-γ immunity to pooled B16 epitopes and to the universal tumor antigen, survivin (ref. 42 and Figure 7C). Immunogenicity and antitumor effects of the WH-neoepitope-TNE vaccine were Th cell-dependent, as the significant tumor suppression observed with WH-TNE was lost if CD4 + T cells were depleted during treatment ( Figure 7D).…”
Section: Cific Cd4mentioning
confidence: 99%
“…The effect of the immune response was amplified when HER2 immunization was combined to a temporary regulatory T-cell depletion treatment, but only if the microscopic cancer was small enough (not palpable, Rolla et al, 2010). Other recent results describe the efficacy of the xenogenic chicken HSP70 antigen in a prime boost strategy for a canine transmissible venereal tumor (Yu et al, 2011), metalloproteinase MMP11 antigen in a colon cancer mouse model (Peruzzi et al, 2009), cancer testis antigen PASD1 fused to the tetanus toxin DOM epitope in a multiple myeloma mouse model ( Joseph-Pietras et al, 2010), a human surviving epitope against the B16 melanoma mouse model after intradermal delivery (Lladser et al, 2010), or secreted telomerase combined with an adenovirus boost in a dog lymphoma model (Peruzzi et al, 2010).…”
Section: Cancermentioning
confidence: 94%
“…Lladser et al published two reports on a naked DNA vaccine targeting survivin [72,71]. In the first report mice were given three intramuscular injections with human survivin expressing plasmids together with a plasmid coding for the murine granulocyte-macrophage colony-stimulating factor (pGM-CSF).…”
Section: Survivinmentioning
confidence: 99%
“…In an in-vivo matrigel plug assay anti-angiogenic properties of this vaccine were demonstrated. Unfortunately, no attempts were made to investigate the humoral immune response and its possible role in tumor protection [71].…”
Section: Survivinmentioning
confidence: 99%