Intradermal BCG vaccination complications— Analysis of 51 cases

Souza, Gilvan Renato Muzy de; Sant’Anna, Clemax Couto; Silva, José Roberto Lapa e; Mano, D.B.; Bethlem, N

doi:10.1016/0041-3879(83)90046-6

Cited by 45 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Once the organisms were identified, subsequent cases were treated as BCG abscesses by aspirations and INH therapy, de Souza et al reported a rapid resolution (30 days) in 19 of 27 cases on systemic INH therapy. 3 A rapid resolution was also seen in our cases but complete recovery required two to four months. In the majority of cases, we neither saw any advantage of a two drug regimen over one nor surgery over chemotherapy.…”

Section: Discussionsupporting

confidence: 49%

“…2,3,7 Most of the reports are not well documented by microbiological studies or consist of small groups of cases only. A report on 18 cases with abscess formation from Zaire showed AFB positivity in 75% while M. bovis was isolated from 63% of patients.…”

Section: Discussionmentioning

confidence: 99%

“…Local complications following BCG, such as abscess formation and adenitis, are well known and amount to less than 2% of the vaccinated individuals. [1][2][3][4] Local complications following hepatitis vaccine are not described. We report 25 cases of post vaccination subcutaneous abscesses in the thigh, the site of hepatitis vaccination.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Development of Subcutaneous Abscesses due to Mycobacterium Bovis Following Hepatitis and Bacillus Calmette-Guerin Vaccination

Kafeel

Sh²,

Sa³

et al. 1994

Annals of Saudi Medicine

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 49%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Development of Subcutaneous Abscesses due to Mycobacterium Bovis Following Hepatitis and Bacillus Calmette-Guerin Vaccination

Kafeel

Sh²,

Sa³

et al. 1994

Annals of Saudi Medicine

View full text Add to dashboard Cite

“…Factors associated with the development of local complications include the type, dose and strength of the vaccine strain, technique of inoculation, age, race, immune status of the recipient and previous positive tuberculin skin reaction (6). Muzy de Souza et al (14), in a study of 117,533 vaccinees, reported an incidence of local complications of 0.04% (51 patients), with 55% of these being abscesses. Other adverse reactions were ulcer formation, lymphangitis, suppurative adenitis and cheloid.…”

Section: Discussionmentioning

confidence: 99%

A Complication of BCG Vaccine: A Case of Localized Cutaneous Abscess due to Mycobacterium bovis

Lussier

Bourgault

Gaudreau

et al. 1998

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

The attenuated bacille Calmette-Guérin (BCG) vaccine is administered to prevent tuberculosis. Complications of vaccination are uncommon. A case of cutaneous abscess due to BCG is presented in a 24-year-old woman. The abscess developed at the inoculation site four weeks after vaccination. Routine Gram stain and bacterial cultures of the pus were negative. The auramine stain was positive. Mycobacterial cultures were positive after 14 and 18 days, using the BACTEC 12B bottle and Löwenstein-Jensen media, respectively. The mycobacteria were identified asMycobacterium bovis, vaccinal strain by high-performance liquid chromatography and DNA probe assays.

show abstract

“…Although reports of adverse reactions arising from the use of BCG are relatively uncommon (11), there are many factors believed to cause side effects (12), such as the substrain (12,13) and route of administration (11,(13)(14)(15)(16). In wildlife and domestic animals, although several species have been vaccinated by different routes (11,17), no adverse reactions other than local reactions in badgers and some systemic reactions in cattle have been reported (11,18).…”

mentioning

confidence: 99%

Assessment of an Oral Mycobacterium bovis BCG Vaccine and an Inactivated M. bovis Preparation for Wild Boar in Terms of Adverse Reactions, Vaccine Strain Survival, and Uptake by Nontarget Species

Beltrán‐Beck

Romero

Sevilla

et al. 2013

Clin. Vaccine Immunol.

View full text Add to dashboard Cite

Wildlife vaccination is increasingly being considered as an option for tuberculosis control. We combined data from laboratory trials and an ongoing field trial to assess the risk of an oral Mycobacterium bovis BCG vaccine and a prototype heat-inactivated Mycobacterium bovis preparation for Eurasian wild boar (Sus scrofa). We studied adverse reactions, BCG survival, BCG excretion, and bait uptake by nontarget species. No adverse reactions were observed after administration of BCG (n ‫؍‬ 27) or inactivated M. bovis (n ‫؍‬ 21). BCG was not found at necropsy (175 to 300 days postvaccination [n ‫؍‬ 27]). No BCG excretion was detected in fecal samples (n ‫؍‬ 162) or in urine or nasal, oral, or fecal swab samples at 258 days postvaccination (n ‫؍‬ 29). In the field, we found no evidence of loss of BCG viability in baits collected after 36 h (temperature range, 11°C to 41°C). Camera trapping showed that wild boar (39%) and birds (56%) were the most frequent visitors to bait stations (selective feeders). Wild boar activity patterns were nocturnal, while diurnal activities were recorded for all bird species. We found large proportions of chewed capsules (29%) (likely ingestion of the vaccine) and lost baits (39%) (presumably consumed), and the proportion of chewed capsules showed a positive correlation with the presence of wild boar. Both results suggest proper bait consumption (68%). These results indicate that BCG vaccination in wild boar is safe and that, while bait consumption by other species is possible, this can be minimized by using selective cages and strict timing of bait deployment.

show abstract

Intradermal BCG vaccination complications— Analysis of 51 cases

Cited by 45 publications

References 0 publications

Development of Subcutaneous Abscesses due to Mycobacterium Bovis Following Hepatitis and Bacillus Calmette-Guerin Vaccination

Development of Subcutaneous Abscesses due to Mycobacterium Bovis Following Hepatitis and Bacillus Calmette-Guerin Vaccination

A Complication of BCG Vaccine: A Case of Localized Cutaneous Abscess due to Mycobacterium bovis

Assessment of an Oral Mycobacterium bovis BCG Vaccine and an Inactivated M. bovis Preparation for Wild Boar in Terms of Adverse Reactions, Vaccine Strain Survival, and Uptake by Nontarget Species

Contact Info

Product

Resources

About