Purpose: The aim of this study was to focusing on pathogenesis, clinical and histological signs, diagnosis and treatment of canine atopic dermatitis (AD). Findings of the studies used in this review contributed to the current knowledge about the disease and allowed the discussion of diagnostic criteria, and treatment. Results: The pathogenesis diagnostic and treatment have been updated. The management of AD should involve the elimination of, the ethiology, bathing with mild shampoos, and controlling pruritus and skin lesions with interventions that include topical and/or oral glucocorticoids or oclacitinib. For chronic canine AD, the management should include the identification and avoidance of flare factors, as well as ensuring that there is adequate skin and coat hygiene and care; this might include more frequent bathing and possibly increasing essential fatty acid intake. The medications currently most effective in reducing chronic pruritus and skin lesions are topical and oral glucocorticoids, oral ciclosporin, oral oclacitinib, and, where available, injectable recombinant interferons. Allergen-specific immunotherapy and proactive intermittent topical glucocorticoid applications are the only interventions likely to prevent or delay the recurrence of flares of AD. Conclusions: A better definition of the clinical appearance and histopathology of canine AD are available. New sets of diagnostic criteria have been developed, and additional breed-associated differences in phenotypes have been demonstrated. Importantly advances in treatment are described and vary between dogs and, for the same dog, between times when the disease is at different stages.