Intracytoplasmic sperm injection does not improve the outcome of IVF treatments in patients with advanced maternal age or low oocyte number: A randomized controlled trial

Fancsovits, Péter; Lehner, Adam; Kaszas, Zita; Nemes, A.; Dudas, Beata; Joo, Kata; Murber, Ákos; Berkes-Bara, Eva; Fekecs, Gyorgyi; Urbancsek, János

doi:10.1016/j.jogoh.2023.102625

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…A possible explanation for this is that only one single sperm is used from the semen solution during ICSI. Although the use of ICSI is expensive and it is not always beneficial in cases of non-male factor infertility [ 20 ], some working groups have suggested that it may help to avoid contamination of the culture solution [ 8 , 15 ]. On the basis of this, we planned ICSI treatment after the failed IVF cycle and were able to avoid bacterial infection in the culture medium.…”

Section: Discussionmentioning

confidence: 99%

Successful pregnancy with intracytoplasmic sperm injection after bacterial contamination of embryo culture in in vitro fertilization: a case report

Berkes-Bara,

Nemes,

Dudas

et al. 2024

J Med Case Reports

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Background Bacterial infection of embryo culture medium is rare but may be detrimental. The main source of embryo culture contamination is semen. Assisted reproduction centers currently lack consensus regarding the methods for preventing and managing embryo culture infection. In our recent case, a successful pregnancy was achieved with intracytoplasmic sperm injection after failed conventional in vitro fertilization owing to bacterial contamination. Case presentation We present a case report of two consecutive in vitro fertilization–intracytoplasmic sperm injection cycles with photo and video documentation of the bacterial growth. A 36-year-old Hungarian woman and her 37-year-old Hungarian partner came to our department. They had two normal births followed by 2 years of infertility. The major causes of infertility were a closed fallopian tube and asthenozoospermia. Bacterial infection of the embryo culture medium was observed during in vitro fertilization and all oocytes degenerated. The source was found to be the semen. To prevent contamination, intracytoplasmic sperm injection was used for fertilization in the subsequent cycle. Intracytoplasmic bacterial proliferation was observed in one of the three fertilized eggs, but two good-quality embryos were successfully obtained. The transfer of one embryo resulted in a successful pregnancy and a healthy newborn was delivered. Conclusion Intracytoplasmic sperm injection may be offered to couples who fail conventional in vitro fertilization treatment owing to bacteriospermia, as it seems to prevent infection of the embryo culture. Even if bacterial contamination appears, our case encourages us to continue treatment. Nevertheless, the development of new management guidelines for the prevention and management of bacterial contamination is essential.

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Section: Discussionmentioning

confidence: 99%

Successful pregnancy with intracytoplasmic sperm injection after bacterial contamination of embryo culture in in vitro fertilization: a case report

Berkes-Bara,

Nemes,

Dudas

et al. 2024

J Med Case Reports

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“…Furthermore, the ongoing innovations in ICSI technique and its integration into ART protocols are carefully reviewed in works such as that of Fancsovits Peter et al., which critically evaluates the results of ICSI in different infertility scenarios, including those with advanced maternal age or low oocyte number. 178 Such research contributes to a comprehensive understanding of the parameters within which ICSI optimizes reproductive success and delineates its impact compared to traditional IVF methods.…”

Section: Prospects For Icsimentioning

confidence: 99%

Evolution of intracytoplasmic sperm injection: From initial challenges to wider applications

Asada

2024

Reprod Medicine & Biology

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BackgroundIn vitro fertilization (IVF) has revolutionized infertility treatment. Nevertheless, male infertility requires more effective solutions. In 1992, the first‐ever case of human birth via intracytoplasmic sperm injection (ICSI) was reported. ICSI involves microscopically injecting a sperm into an ovum. Successful ICSI has become a reliable therapy for couples facing infertility, a significant milestone. However, it has also introduced various challenges. This study also delves into ethical dilemmas arising from widespread ICSI use.MethodsThis review traces the history of ICSI, presenting pioneering attempts, first successful attempts, and critical reports on account of the initial skepticism toward the technology. The review also focuses on chronological progress until ICSI was recognized as effective and became widely applied.Main findingsThe review reveals that ICSI, although transformative, presents challenges. Successes include addressing male infertility and aiding fertilization. However, concerns arise regarding optimal sperm and embryo selection, genetic mutations, and long‐term health implications. Ethical considerations surrounding ICSI's broad applications also surface.ConclusionsDespite its success and effectiveness, ICSI is still evolving as a therapeutic method. By comprehensively evaluating the historical progress and the current status of ICSI and exploring its future prospects, this study highlights the importance of ICSI in infertility treatment.

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Analysis of use of different rFSHs during IVF/ICSI-assisted conception in elderly population and effect of double trigger on clinical outcomes

Ma,

Wang,

Zuo

et al. 2024

The Journal of Maternal-Fetal & Neonatal Medicine

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Intracytoplasmic sperm injection does not improve the outcome of IVF treatments in patients with advanced maternal age or low oocyte number: A randomized controlled trial

Cited by 3 publications

References 28 publications

Successful pregnancy with intracytoplasmic sperm injection after bacterial contamination of embryo culture in in vitro fertilization: a case report

Successful pregnancy with intracytoplasmic sperm injection after bacterial contamination of embryo culture in in vitro fertilization: a case report

Evolution of intracytoplasmic sperm injection: From initial challenges to wider applications

Analysis of use of different rFSHs during IVF/ICSI-assisted conception in elderly population and effect of double trigger on clinical outcomes

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