Intracytoplasmic lumina in invasive micropapillary carcinoma of the lung

Hamaguchi, Nobumasa; Ohara, Masahiko; Hirouchi, Takashi; Miyzaki, E.; Mizuno, Keiko

doi:10.1002/dc.20427

Cited by 18 publications

(22 citation statements)

References 12 publications

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“…After 13 years, the term invasive micropapillary carcinoma of the breast was proposed by Siriaunkgul and Tavassoli. 2 This morphologic pattern was subsequently identified in tumors of other organs, such as urinary bladder in 1994, 3 colon in 2005, 4 and lung in 2006, 5 and the IMPC terminology was also adopted for those tumors.…”

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confidence: 99%

Invasive Micropapillary Carcinoma of the Breast: An Update

Yang¹,

Liu²,

Zhang³

et al. 2016

Archives of Pathology &Amp; Laboratory Medicine

119

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Context.-Invasive micropapillary carcinoma (IMPC) is a distinct variant of mammary carcinoma in which tumor cells are arranged in morulelike clusters devoid of fibrovascular cores and situated within empty stromal spaces. Identification of IMPC can be achieved by the assessment of morphologic features in conjunction with the characteristic ''inside-out'' staining pattern of epithelial membrane antigen and sialyl Lewis X highlighted by immunohistochemical analysis. Although recognizing micropapillary architecture is often not challenging, the criteria for distinguishing between mixed and pure IMPC remain imprecise. Some mucin-producing carcinomas can also have micropapillary histology, but there is no consensus on whether these tumors are variants of IMPC or mucinous carcinomas. The molecular genetic studies demonstrate that IMPCs have distinct molecular genetic profiles, supporting the theory that they constitute distinct pathologic entities. However, genomic analyses have not identified any specific genomic aberration that may explain the distinctive morphology and clinical behavior of IMPC.Objective.-To provide an overview on the current concepts in the diagnosis and pathogenesis of IMPC of the breast, incorporating recent molecular genetic advances and prognosis-based reclassification.Data Sources.-PubMed search and the cited references were reviewed.Conclusions.-The recent evolution of prognosis-based reclassification and molecular genetic advances has enhanced our knowledge of the pathogenesis of IMPC of the breast. Additional studies might reveal consistent molecular alterations that underlie the formation of the inside-out growth pattern, and they might elucidate the molecular mechanisms responsible for the unfavorable clinical behavior of IMPC.

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confidence: 99%

Invasive Micropapillary Carcinoma of the Breast: An Update

Yang¹,

Liu²,

Zhang³

et al. 2016

Archives of Pathology &Amp; Laboratory Medicine

119

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“…IMPC was firstly reported as a rare variant of invasive breast cancer by Siriaunkgul and Tavassoli in 1993 . In addition to the breast, cancers exhibiting the IMPC pattern have been reported in the lung, stomach, salivary gland, pancreas, colorectum and urinary bladder, and other sites . However, to the best of our knowledge, there are no reports about IMPC of the EGJ.…”

Section: Discussionmentioning

confidence: 98%

“…Invasive micropapillary carcinoma (IMPC) is a carcinoma composed of small papillary clusters surrounded by a clear space. IMPC has been recognized as an aggressive variant of adenocarcinoma because of the high incidence of lymphatic invasion in various organs, including the breast, lung, stomach, salivary gland, pancreas, colorectum and urinary bladder . However, pure IMPC has only reported to occur in the breast, pancreas and colon .…”

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confidence: 99%

Pure invasive micropapillary carcinoma of the esophagogastric junction with lymph nodes and liver metastasis

Hattori

Sentani

Hattori

et al. 2016

Pathology International

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Invasive micropapillary carcinoma (IMPC), an aggressive variant of adenocarcinoma, is associated with a poor prognosis. Although IMPC has been reported to occur in various organs, pure IMPC has only been reported in the breast, pancreas and colon. There are no reports of IMPC of the esophagogastric junction (EGJ). According to previous reports on gastric IMPC, IMPC occupied, at most, 90 % of the whole tumor. IMPC is reported to occur least frequently in the gastric cardia. We herein report a rare case of pure IMPC of the EGJ. A 71-year-old male patient presented with epigastric distress. Gastric endoscopy demonstrated an irregularly-elevated lesion of 50 mm in diameter at the EGJ. The patient underwent proximal gastrectomy, resection of the regional lymph nodes and a punch biopsy of the liver. A histopathological examination revealed that almost all of the regions, including the lymph nodes and the sites of liver metastasis, contained IMPC and that a minute region (<1 % of the whole cancer) contained tubular or papillary adenocarcinoma. The further accumulation of pure IMPC cases like the present case would help to elucidate its pathogenesis.

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“…Micropapillary carcinoma of the lung is a recently described entity and is characterized by small papillary tufts lacking a fibrovascular core 1,2 . This tumor pursues an aggressive clinical course because of the propensity for the metastasis into lymph nodes and pleural invasion 1–7 . Some investigators have reported that pulmonary micropapillary carcinoma is frequently associated with other subtypes of adenocarcinoma, including acinar, papillary, bronchioloalveolar, mucinous and solid patterns 1–7 .…”

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confidence: 99%

“…This tumor pursues an aggressive clinical course because of the propensity for the metastasis into lymph nodes and pleural invasion 1–7 . Some investigators have reported that pulmonary micropapillary carcinoma is frequently associated with other subtypes of adenocarcinoma, including acinar, papillary, bronchioloalveolar, mucinous and solid patterns 1–7 . In contrast, cases of papillary adenocarcinoma of the lung reported by some investigators contain micropapillary carcinoma 8,9 .…”

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confidence: 99%