Intracytoplasmic filamentous inclusions and<i>IGHV</i>rearrangements in a patient with chronic lymphocytic leukemia

Rodríguez, Cecilia; Stanganelli, Carmen; Bussi, Claudio; Arroyo, Daniela S.; Sastre, Darío; Heller, Viviana; Iribarren, Pablo; Slavutsky, Irma

doi:10.1080/10428194.2017.1370549

Cited by 3 publications

(3 citation statements)

References 17 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Deposition of such crystals in renal tubular cells, the crystalline variant of light chain proximal tubulopathy, causing partial or complete Fanconi syndrome, has been described in association with CSH . Similar, albeit smaller and less abundant crystals may form within the endoplasmic reticulum of the neoplastic lymphocytes (chronic lymphocytic leukemia) or neoplastic plasma cells themselves, and may be referred to as Auer‐rod‐like inclusions …”

Section: Differential Diagnosis Of Crystals In Bone Marrow Specimensmentioning

confidence: 99%

Bone marrow imprints of crystal‐storing histiocytosis

Kılıç

Picken

Velankar

et al. 2019

Diagnostic Cytopathology

View full text Add to dashboard Cite

Section: Differential Diagnosis Of Crystals In Bone Marrow Specimensmentioning

confidence: 99%

Bone marrow imprints of crystal‐storing histiocytosis

Kılıç

Picken

Velankar

et al. 2019

Diagnostic Cytopathology

View full text Add to dashboard Cite

“…Flow cytometry analysis revealed a clonal B cell population with a typical CLL phenotype. Prognostic marker analysis showed 58% of ZAP-70-and 80% of CD38-positive cells (15). Thus, a diagnostic of CLL Rai stage II was done, and the patient was treated with bendamustine from 2009 to 2016 because progressive systemic symptoms were present.…”

Section: Patient #1mentioning

confidence: 99%

“…Lactate dehydrogenase (LDH) and B2-microglobulin (B2M) values were 257 UI/L and 3.6 mg/L, respectively (reference values: LDH: 180-450 UI/L; B2M: 0.8-2.20 mg/L). Flow cytometry analysis revealed a clonal B cell population with a typical CLL phenotype, expressing prognostic markers ZAP-70 and CD38 (15). Thus, a diagnostic of CLL Rai stage II was done, and progression was detected in October 2010.…”

Section: Patient #2mentioning

confidence: 99%

Increased Expression of Autophagy Protein LC3 in Two Patients With Progressing Chronic Lymphocytic Leukemia

et al. 2020

Self Cite

View full text Add to dashboard Cite

Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia in the western hemisphere. It is characterized by a clonal proliferation of a population of CD5+ B lymphocytes that accumulate in the secondary lymphoid tissues, bone marrow, and blood. Some CLL patients remain free of symptoms for decades, whereas others rapidly become symptomatic or develop high-risk disease. Studying autophagy, which may modulate key protein expression and cell survival, may be important to the search for novel prognostic factors and molecules. Here, we applied flow cytometry technology to simultaneously detect autophagy protein LC3B with classical phenotypical markers used for the identification of tumoral CLL B cell clones. We found that two patients with progressing CLL showed increased expression of the autophagy protein LC3B, in addition to positive expression of CD38 and ZAP70 and unmutated status of IGHV. Our data suggest that activation of autophagy flux may correlate with CLL progression even before Ibrutinib treatment.

show abstract