Intracystic papillary carcinoma of the breast in males

Luo, Hua; Meng, Kexin; He, Jinlan; Hu, Zujian; Yang, Ouou; Lan, Tian; Su, Kunlun; Yang, Huifen; Zhan, Chenni; Xu, Huiling

doi:10.1097/md.0000000000020278

Cited by 8 publications

(12 citation statements)

References 20 publications

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“…It accounts for up to 2% of cases in women, whereas in men the incidence is less than 1%. The average age of its onset ranges from 68 to 84 years, and it mainly affects women, being unusual for men 4 . It is characterized as intracystic papillary growth carcinoma of the breast, mostly unilateral growth.…”

Section: Discussionmentioning

confidence: 99%

“…It is characterized as intracystic papillary growth carcinoma of the breast, mostly unilateral growth. The diagnosis is usually localized, without dissemination to lymph nodes or with distant metastases 3,4,10 . In the reported patient, the tumor presentation was at 41 years of age, lower than the epidemiological data, and it was well-localized and without dissemination and/or metastases.…”

Section: Discussionmentioning

confidence: 99%

“…Microscopically, the capsule can be filled by a fibrovascular layer, and its stroma is characterized by cells distributed in clearly papillary structures. However, they can present a malignant cellular aspect, with the presence of atypia 4,5,10 .…”

Section: Discussionmentioning

confidence: 99%

“…It has a good prognosis. Its 10-year survival rate is 100% and the recurrence-free rate is 95%, which shows that, despite being a rare cancer, it has a high survival rate and a low recurrence rate [1][2][3][4][5][6][7][8] . Thus, to document the occurrence of breast cancer in men is deemed very relevant to identify possible risk factors, to develop more specific therapeutic strategies and even future prevention measures.…”

Section: Introductionmentioning

confidence: 99%

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Solid intracystic papillary carcinomain male breast: case report

et al. 2021

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The intracystic papillary carcinoma (IPC) is one of the rarest types of breast cancer, mainly in men, representing less than 1% of the malignant diseases in the male sex. It is frequently associated with the ductal carcinoma in situ (DCIS), but there are also other forms such as the pure and the invasive ones. The male population breast cancer diagnosis is late and, therefore, it has a worse prognosis. The diagnosis is given by imaging tests and anatomopathological studies. The treatment consists of excisional tumor therapy, which can be carried out conservatively or through mastectomy, with or without adjuvant therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Solid intracystic papillary carcinomain male breast: case report

et al. 2021

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“…[ 2 , 3 ] For patients with negative axillary lymph nodes, SLN biopsy can safely and effectively replace axillary lymph node dissection and improve the quality of life of patients. [ 4 ] The commonly used tracing methods of SLN biopsy in clinic are radionuclide method and blue dye method. It's been reported that the combination of those 2 methods can significantly increase the success rate of SLN biopsy and reduce its false negative rate.…”

Section: Introductionmentioning

confidence: 99%

Preoperative evaluation and influencing factors of sentinel lymph node detection for early breast cancer with contrast-enhanced ultrasonography

Ling

2021

Medicine

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Sentinel lymph node (SLN) is important in the early diagnosis of breast cancer. We aimed to evaluate the role of contrast-enhanced ultrasonography (CEUS) in the preoperative evaluation for SLN and potentially influencing factors, to provide evidence to the management of breast cancer. Patients with breast cancer who treated in our hospital from May 2018 to May 2020 were selected. All patients underwent CEUS examination to find SLN and judged whether the lymph node had cancer metastasis. We evaluated the sensitivity, specificity, and accuracy of CEUS in predicting SLN, and its differences in pathological diagnosis results and related influencing factors were also analyzed. A total of 108 patients with breast cancer were included. And a total of 248 SLNs were detected. The sensitivity of CEUS to the preoperative evaluation of SLN was 84.67%, the specificity was 81.14%, the positive predictive value was 76.08%, and the negative predictive value was 89.27%, the positive likelihood ratio was 4.06, and the negative likelihood ratio was 0.14. The area under the curve of the preoperative evaluation of SLN in CEUS examination was 0.813 (95% confidence interval: 0.765–0.911), and there was significant difference in the size of SLNs between SLN-negative and SLN-positive groups ( P = .043). Preoperative CEUS has good predictive value for the SLN detection in patients with breast cancer, and it is worthy of clinical application.

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Cystic Encapsulated Papillary Carcinoma in the Male Breast: An Unusual Feature With a Diagnostic Challenge

Saluja

Mai

et al. 2021

Int J Surg Pathol

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Papillary carcinoma in the male breast is uncommon. Here, we report a case of a large encapsulated papillary carcinoma (EPC) in a 62-year-old male. The patient presented with a left breast mass of 1-year duration and bloody nipple discharge for several days. Mammography and breast ultrasonography showed a large left breast mass. The initial biopsy demonstrated fat necrosis with acute and chronic inflammation only. Due to clinical suspicion, a repeat biopsy was performed and revealed scant fragments of papillary carcinoma in a background of inflammation. The patient underwent left total mastectomy. Grossly, the breast contained a 9.0 cm entirely cystic lesion lined by a hemorrhagic thick fibrotic wall. No solid area was identified in the cyst. The entire cyst wall was examined under microscopy; only a few sections with papillary carcinoma were identified. The lesion was confined to the cyst wall; so, a diagnosis of EPC was made. Compared to the previously reported EPC cases of male breast, the lesion of this case was unusually cystic, which making the diagnosis challenging. Therefore, awareness of this unusual feature, repeat biopsy when the pathology result is discordant, and extensive sampling of the lesion are essential for making the correct diagnosis and guiding patient management.

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Intracystic papillary carcinoma of the breast in males

Cited by 8 publications

References 20 publications

Solid intracystic papillary carcinomain male breast: case report

Solid intracystic papillary carcinomain male breast: case report

Preoperative evaluation and influencing factors of sentinel lymph node detection for early breast cancer with contrast-enhanced ultrasonography

Cystic Encapsulated Papillary Carcinoma in the Male Breast: An Unusual Feature With a Diagnostic Challenge

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