Intracystic hyperreflective material in centre-involving diabetic macular oedema

Venkatesh, Ramesh; Sangai, Sajjan; Reddy, Nikitha Gurram; Sridharan, Akhila; Pereira, Arpitha; Aseem, Aditya; Gadde, Santosh Gopi Krishna; Yadav, Naresh Kumar; Chhablani, Jay

doi:10.1007/s00417-021-05083-6

Cited by 2 publications

(3 citation statements)

References 28 publications

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“…Among young patients with diabetes who have no CI-DME at presentation, we found that, in 17% of eyes, DME occurred at a median time gap of 9 months after presentation. visual prognosis (19)(20)(21)(22)(23)(24)(25)(26). The analysis using the Spearman correlation test showed significant correlation of independent variables such as presenting visual acuity, stage of DR, and disruption of the IS-OS junction layer with final visual acuity.…”

Section: Discussionmentioning

confidence: 88%

Diabetic Retinopathy and Diabetic Macular Edema in People With Early-Onset Diabetes

et al. 2022

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This study examined the clinical profile, treatment profile, and vision outcomes of people ≤40 years of age with diabetes and diabetic macular edema (DME). Within this age-group, the prevalence of center-involving DME was 16%, with 74% of eyes showing cystoid edema, 37% showing spongiform edema, and 41% having neurosensory detachment. Longer diabetes duration (P = 0.001) and greater severity of diabetic retinopathy (P <0.001) were associated with DME prevalence. Thus, regular and more frequent follow-up, as well as early and aggressive treatment of diabetic eye disease, are required in people diagnosed early with diabetes.

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Section: Discussionmentioning

confidence: 88%

Diabetic Retinopathy and Diabetic Macular Edema in People With Early-Onset Diabetes

et al. 2022

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Section: Introductionmentioning

confidence: 99%

“…Clinically, another newly described SD-OCT feature is believed to be correlated with HRF, which is enhanced internal reflectivity of the edema cyst [ 27 , 28 ]. The enhanced internal reflectivity of the cyst was defined as the presence of clump of hyperreflective material present in the intraretinal space [ 28 ] or presence of a plume-shaped hyper-reflective substance within the cyst [ 29 ]. In addition to the correlation with HRF, the enhanced internal reflectivity of the cyst is also believed to be related to ME prognosis [ 27 ], thus the enhanced internal reflectivity is also described along with HRF in ME patients.…”

Section: Introductionmentioning

confidence: 99%

Comparison of hyperreflective foci in macular edema secondary to multiple etiologies with spectral-domain optical coherence tomography: An observational study

et al. 2022

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Background Hyperreflective foci (HRF) features in macular edema associated with different etiologies may indicate the disease pathogenesis and help to choose proper treatment. The goal of this study is to investigate the retinal microstructural features of macular edema (ME) secondary to multiple etiologies with spectral-domain optical coherence tomography (SD-OCT) and analyze the origin of HRF in ME. Methods This was a retrospective study. SD-OCT images were reviewed to investigate macular microstructural features such as the number and distribution of HRF and hard exudates and the internal reflectivity of the cysts. The differences in microstructural features between groups and the correlations between the number of HRF and other parameters were analyzed. Results A total of 101 eyes with ME from 86 diabetic (diabetic macular edema, DME) patients, 51 eyes from 51 patients with ME secondary to branch retinal vein occlusion (branch retinal vein occlusion-macular edema, BRVO-ME), 59 eyes from 58 central retinal vein occlusion (central retinal vein occlusion-macular edema, CRVO-ME) patients, and 26 eyes from 22 uveitis (uveitic macular edema, UME) patients were included in this study. The number of HRF, the frequency of hard exudates and the enhanced internal reflectivity of the cysts were significantly different among the groups. The number of HRF in the DME group was significantly higher than that in the other groups (all P < 0.05). The frequency of hard exudates and enhanced internal reflectivity of the cysts in the DME group were significantly higher than ME secondary to other etiologies (all P < 0.001). Within the DME group, the number of HRF in the patients with hard exudates was significantly higher than that in the patients without hard exudates (P < 0.001). Conclusion HRF detected with SD-OCT were more frequent in DME patients than in BRVO-ME, CRVO-ME, or UME patients. The occurrence of HRF was correlated with the frequency of hard exudates. HRF may result from the deposition of macromolecular exudates in the retina, which is speculated to be a precursor of hard exudates.

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Intracystic hyperreflective material in centre-involving diabetic macular oedema

Cited by 2 publications

References 28 publications

Diabetic Retinopathy and Diabetic Macular Edema in People With Early-Onset Diabetes

Diabetic Retinopathy and Diabetic Macular Edema in People With Early-Onset Diabetes

Comparison of hyperreflective foci in macular edema secondary to multiple etiologies with spectral-domain optical coherence tomography: An observational study

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