Intracutaneous botulinum toxin A versus ablative therapy of Hailey-Hailey disease - a case report

Konrad, H; Karamfilov, Theodor; Wollina, Uwe

doi:10.1080/14764170160260762

Cited by 54 publications

(47 citation statements)

References 12 publications

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“…There is a wide range of benign tumors, cysts or hyperkeratotic disorders that have been successfully treated or at least alleviated by erbium-YAG laser application such as nevus sebaceous, actinic porokeratosis, osteoma cutis or angiokeratoma [25][26][27][28][29].…”

Section: Discussionmentioning

confidence: 99%

Erbium-YAG laser therapy – analysis of more than 1,200 treatments

Wollina¹

2016

Glob Dermatol

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Section: Discussionmentioning

confidence: 99%

Erbium-YAG laser therapy – analysis of more than 1,200 treatments

Wollina¹

2016

Glob Dermatol

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“…[23][24][25][26][27][28][29][30][31][32][33] Botulinum toxin (axillary or inframammary) may help by reducing sweating, as may breast reduction. [34][35][36] Although ultraviolet light may exacerbate Hailey-Hailey disease, PUVA was apparently effective in some patients. Suberythemal UVB controlled both psoriasis and co-existing Hailey-Hailey disease in another patient.…”

Section: Treatmentmentioning

confidence: 99%

Hailey Hailey disease-a rare case report

et al. 2016

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Hailey-Hailey disease is an autosomal dominant acantholytic disorder relatively uncommon in India. It is characterized by painful, pruritic, foul smelling vesicles and bullous lesions with erosions in intertriginous areas such as the neck, axillae, inframammary areas and groin. The defect in ATPC2 gene leads to calcium channel dysfunction which results in defect in epidermis. Fungal infection, intertrigo, psoriasis, extramammary Paget's disease, acanthosis nigricans, pemphigus vegetans and Darier's disease are some of the dermatosis from which it needs to be differentiated. Histopathology has a key role in diagnosis of Hailey-Hailey disease with characteristic ‘dilapidated brick wall' appearance. Hailey-Hailey disease can be easily misdiagnosed by general physicians due to lack of knowledge of this uncommon disease as it resembles dermatosis involving intertriginous areas. Due to its relapsing and remitting course there is a need to have effective treatment options. We report a case of 45 year old middle aged female who presented with on and off itchy papules & vesicles over right inframammmary region around the umbilicus & medial aspect of right thigh. Skin biopsy revealed a diagnosis of Hailey-Hailey disease. This case is being reported due to its rare occurrence.

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“…Indications not approved by FDA, but studied and reported in the medical literature, include extracervical spasticities, 8,9 especially for patients with cerebral palsy, [10][11][12][13][14][15][16] poststroke spasticity, 17,18 and piriformis syndrome. 19,20 Other reports describe off-label uses for a wide range of neurologic, [21][22][23][24][25][26] dermatologic, [27][28][29][30][31][32] gastrointestinal, [33][34][35][36][37][38][39][40][41][42] and other clinical [43][44][45][46][47][48][49][50][51] disorders, often without controlled clinical trials. Off-label use of a licensed drug or biologic product occurs with a wide range of products.…”

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confidence: 99%