“…In 1995 Guarino et al indicated that regardless of etiology and age, patients with severe diarrhea who usually need PN should be grouped under ''severe and protracted diarrhea'' (3). After 2000, authors focused on enteropathies because of primary enterocyte abnormalities and immune-mediated disorders (IMD), but some of them decided to investigate anomalous presentations of common etiologies first (10,11). The age at onset of diarrhea of patients varied in studies of children up to 1 or 2 years old (3,4,9).…”