Intractable diarrhea in children with VIP-secretingganglioneuroblastomas

Shafie, M. El; Samuel, Donald; Klippel, Charles H.; Robinson, Margaret G.; Cullen, Bernard J

doi:10.1016/s0022-3468(83)80269-3

Cited by 37 publications

(11 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4,5 In literature, VIP production indicates a favorable prognosis. 6 In contrast to individuals with VIP-secreting pancreatic tumors, patients with neurogenic lesions generally have normal serum levels of pancreatic polypeptide, gastrin, insulin, and somatostatin. [4][5][6] A VIPoma (also known as Verner Morrison syndrome) is a rare endocrine tumor, and usually (about 90%) arise from non-b islet cell of the pancreas, that produce vasoactive intestinal peptide (VIP).…”

Section: Discussionmentioning

confidence: 99%

Ganglioneuroblastoma as Vasoactive intestinal polypeptide-secreting Tumor: Rare Case Report in a Child

Kumar¹,

Kumar²,

Upadhyaya³

et al. 2015

World Journal of Endocrine Surgery

View full text Add to dashboard Cite

Pathologically elevated vasoactive intestinal polypeptide (VIP) plasma levels cause secretory diarrhea with excessive loss of water and electrolyte and is characterized by the typical symptoms of hypokalemia and metabolic acidosis. It rarely occurs in patients with non-pancreatic disease. Despite the clinical severity, diagnosis of a VIP-secreting tumor is often delayed. We herein present a 14-month-old boy having prolonged therapy-resistant secretory diarrhea, persistent hypokalemia with tissue diagnosis of ganglioneuroblastoma and raised plasma VIP-levels. How to cite this article Kumar B, Upadhyaya VD, Rao RN, Kumar S. Ganglioneuroblastoma as Vasoactive Intestinal Polypeptide-secreting Tumor: Rare Case Report in a Child. World J Endoc Surg 2015;7(2):47-50.

show abstract

Section: Discussionmentioning

confidence: 99%

Ganglioneuroblastoma as Vasoactive intestinal polypeptide-secreting Tumor: Rare Case Report in a Child

Kumar¹,

Kumar²,

Upadhyaya³

et al. 2015

World Journal of Endocrine Surgery

View full text Add to dashboard Cite

show abstract

“…2 In general, the possibility of having neuroblastoma after finding an abdominal mass in early postnatal period is about 80%. 5 There are few cases of neuroblastoma with rare presentations, such as obstructive jaundice in infancy period, that are reported in the literature. Involvement of the cerebellum can cause ataxia, dementia, and chaotic eye movements, a syndrome known as opsoclonus-polymyoclonus ataxia.…”

Section: Discussionmentioning

confidence: 99%

Neuroblastoma Presenting as Persistent Postprandial Emesis in a Neonate

Rezaimehr

Bhargava²

2013

Pediatric Emergency Care

View full text Add to dashboard Cite

Early identification and treatment of neuroblastoma, the most common malignant solid tumor in infants, (Atkinson et al. AJR Am J Roentgenol. 1986;146:113-117; Nuchtern. Semin Pediatr Surg. 2006;15:10-16; Lanzkowsky. Manual of Pediatric Hematology and Oncology. 4th ed. Burlington, MA: Elsevier Academic Press; 2005:530-547) can improve prognosis of this illness. Benign emesis as an initial presentation of infantile neuroblastoma is rare (Isaacs. Fetal Pediatr Pathol. 2007;26:177-184). We report a case of a 17-day-old healthy male who presented to the emergency department with persistent, nonprojectile emesis after feedings. A diagnosis of nonresectable stage IV thoracoabdominal neuroblastoma with invasion to the spine was made. We concluded that oncological processes, such as neuroblastoma, should be included in the differential diagnosis of persistent emesis in the neonatal period. Emergency physicians may have the opportunity to detect neuroblastoma earlier by contemplating a broader differential diagnosis of a vomiting infant and initiating the appropriate workup in the emergency department.

show abstract

“…WDHA was later described in 12 children who also had increased VIP concentrations both in the plasma and in the tumor. Symptoms and signs (diarrhea, electrolyte imbalance) disappeared after was corrected with removal of the mass [5].…”

Section: Discussionmentioning

confidence: 99%