Intracranial Volume Not Correlated With Severity in Trigonocephaly

Abstract

Objectives: Severity of trigonocephaly varies and potentially affects intracranial volume (ICV) and intracranial pressure (ICP). The aim of this study is to measure ICV in trigonocephaly patients and compare it to normative data and correlate ICV with the severity of the skull deformity according to UCSQ (Utrecht Cranial Shape Quantifier). Design: Retrospective study. Setting: Primary craniofacial center. Patients, Participants: Nineteen preoperative patients with nonsyndromic trigonocephaly (age ≤12 months). Intervention: Intracranial volume was measured on preoperative computed tomography (CT) scans by manual segmentation (OsiriX Fondation). Utrecht Cranial Shape Quantifier was used to quantify the severity of the skull deformity. When present, papilledema as sign of elevated ICP was noted. Main Outcome Measures(s): Measured ICV was compared to Lichtenberg normative cranial volume growth curves, and Pearson correlation coefficient was used to correlate UCSQ with the ICV. Results: Mean age at CT scan was 6 months (2-11). Mean measured ICV was 842 mL (579-1124). Thirteen of h19 patients (11/15 boys and 2/4 girls) had an ICV between ±2 SD curves of Lichtenberg, 2 of 19 (1/15 boys and 1/4 girls) had an ICV less than −2 SD and 4 of 19 (3/15 boys and 1/4 girls) had an ICV greater than +2 SD. Mean UCSQ severity of trigonocephaly was 2.40 (−622.65 to 1279.75). Correlation between severity and ICV was negligible (r = −0.11). No papilledema was reported. Conclusions: Measured ICV was within normal ranges for trigonocephaly patients, in both mild and severe cases. No correlation was found between severity of trigonocephaly and ICV.

New diagnostic criteria for metopic ridges and trigonocephaly: a 3D geometric approach

“…Decreased ICV in TG has been reported [31][32][33] , as well as conserved volumes in moderate cases (41/58 cases) and decreased volumes in 18/58 severe cases de ned by IFA < 123°3 4 . Surprisingly, we found increased ICV in TG and MR relative to age, independently of sex, compared to the normal cohort, with reasonable reliability as we report the largest series in the literature (10 to 74 patients to date in previous series [31][32][33][34][35][36][37][38][39] ). In MR, a single evaluation reported larger ICV values than in TG 39 , while we report no difference of ICV relative to age between TG and MR.…”

Classification of Skull Shape Deformities Related to Craniosynostosis on 3D Photogrammetry

“…These variables were found to be suitable for quantification purposes for each of the previously mentioned subtypes of craniosynostosis 14–17. UCSQ can be used to identify associations between severity of skull the skull deformity and clinical features 18,19…”