Intracranial Volume in Craniosynostotic Rabbits

Mp, Mooney; Am, Burrows; Wigginton, William; Vk, Singhal; Hw, Losken; Td, Smith; Dechant, Jason; Towbin, Alexander J.; Gm, Cooper; Towbin, Richard B.; Mj, Siegel

doi:10.1097/00001665-199805000-00010

Cited by 23 publications

(24 citation statements)

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“…11,14,19 -24 This premise is supported by a number of studies using indirect intracranial volume measures from computed tomographic scans, which have shown significantly reduced preoperative intracranial volume in patients with craniosynostosis compared with control data. 15,16,25 However, a number of these studies were confounded, in part, by (1) differing techniques of computed tomographic volumetry; (2) heterogeneous or small samples; (3) variable surgical intervention times, procedures, or computed tomographic scan protocols; and (4) the use of inappropriate normative control data 17,18,26,27 ; thus, the relationship between intracranial volume and premature suture fusion still remains unclear.…”

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confidence: 99%

“…To study this relationship, and to address some of the discrepancies and confounding variables noted in previous reports, 17,18,26,27 a series of experimental studies were undertaken in our laboratory to assess age-related intracranial volume changes from three-dimensional, computed tomographic scan reconstructions in a large, homogeneous sample of rabbits with uncorrected, familial coronal suture synostosis and compare them with age-matched, normal control rabbits. In October of 1997, we reported intracranial volume data from 56 wild-type rabbits and rabbits with delayed-or early-onset coronal suture synostosis at 42 and 126 days of age.…”

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confidence: 99%

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Intracranial Volume Changes in Craniosynostotic Rabbits: Effects of Age and Surgical Correction

Cooper

Singhal

Barbano

et al. 2006

Plastic and Reconstructive Surgery

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These data suggest that in rabbits with uncorrected craniosynostosis, compensatory changes in the neurocranium were not capable of compensating for the loss of sutures as growth sites. The results also showed that that surgical release of the synostosed suture improved intracranial volume in the short term (25 to 42 days) but failed to change it in the long term (42 to 84 days), possibly because of rapid resynostosis of the suturectomy site. This study suggests that surgical release of the suture fusion site alone may not be adequate to allow for normal intracranial volume growth in synostotic rabbits. For this reason, it may be efficacious to design and develop adjunct protein and gene therapies to prevent resynostosis and improve postoperative intracranial volume in craniosynostotic individuals.

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confidence: 99%

Intracranial Volume Changes in Craniosynostotic Rabbits: Effects of Age and Surgical Correction

Cooper

Singhal

Barbano

et al. 2006

Plastic and Reconstructive Surgery

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“…Premature coronal suture synostosis is associated with secondary deformities in the cranial vault and cranial base (Babler and Persing, 1982;Vannier, 1985, 1986;Burdi et al, 1986;Babler, 1989;Hoyte, 1989;Mooney et al, 1994b;Burrows et al, 1995;Smith et al, 1996), significantly elevated intracranial pressure (Renier, 1989;Gault et al, 1992;Mooney et al, 1998aMooney et al, , 1999Fellows-Mayle et al, 2000), and altered intracranial volume (Singhal et al, 1997;Hudgins et al, 1998;Mooney et al, 1998a,b;Camfield et al, 2000). These conditions may result in optic nerve compression and papilledema, and, if left uncorrected, optic atrophy, blindness (Miller, 2000), cognitive disabilities, and mental retardation (Kapp-Simmonds et al, 1993;Arnaud et al, 1995;Camfield et al, 2000;Persing and Jane, 2000).…”

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Rescue of coronal suture fusion using transforming growth factor‐beta 3 (Tgf‐β3) in rabbits with delayed‐onset craniosynostosis

et al. 2003

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Craniosynostosis results in cranial deformities and increased intracranial pressure, which pose extensive and recurrent surgical management problems. Developmental studies in rodents have shown that low levels of transforming growth factor-␤3 (Tgf-␤3) are associated with normal fusion of the interfrontal (IF) suture, and that Tgf-␤3 prevents IF suture fusion in a dose-dependent fashion. The present study was designed to test the hypothesis that Tgf-␤3 can also prevent or "rescue" fusing sutures in a rabbit model with familial craniosynostosis. One hundred coronal sutures from 50 rabbits with delayed-onset, coronal suture synostosis were examined in the present study. The rabbits were divided into five groups of 10 rabbits each: 1) sham controls, 2) bovine serum albumin (BSA, 500 ng) low-dose protein controls, 3) low-dose Tgf-␤3 (500 ng), 4) high-dose BSA (1,000 ng) controls, and 5) high-dose Tgf-␤3 (1,000 ng). At 10 days of age, radiopaque amalgam markers were implanted in all of the rabbits on either side of the coronal suture to monitor sutural growth. At 25 days of age, the BSA or Tgf-␤3 was combined with a slow-absorbing collagen vehicle and injected subperiosteally above the coronal suture. Radiographic results revealed that high-dose Tgf-␤3 rabbits had significantly greater (P Ͻ 0.05) coronal suture marker separation than the other groups. Histomorphometric analysis revealed that high-dose Tgf-␤3 rabbits also had patent coronal sutures and significantly (P Ͻ 0.01) greater sutural widths and areas than the other groups. The results suggest that there is a dose-dependent effect of TGF-␤3 on suture morphology and area in these rabbits, and that the manipulation of such growth factors may have clinical applications in the treatment of craniosynostosis. Anat Rec Part A 274A: 962-971, 2003.

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“…Surprisingly, intracranial pressure data do not follow this trend, suggesting that compensatory changes in brain morphology occur between 25 and 42 days of age. By 42 days of age, significant compensatory growth changes have been noted in the cranial vault 17,24,26,38,39 and cranial base 17,24,30 of rabbits with early-onset coronal suture synostosis compared with normal control rabbits. This may explain the decrease in intracranial pressure by 42 days of age.…”

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confidence: 98%

Intracranial Pressure Changes in Craniosynostotic Rabbits

Fellows-Mayle

Mitchell

Losken

et al. 2004

Plastic and Reconstructive Surgery

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Cranial vault and brain deformities in individuals with craniosynostosis are thought to result, in part, from changes in intracranial pressure, but clinical findings are still inconclusive. The present study describes intracranial pressure changes in a rabbit model with naturally occurring, uncorrected coronal suture synostosis. Longitudinal and cross-sectional intracranial pressure data were collected from 241 New Zealand White rabbits, divided into four groups: normal controls (n = 81); rabbits with delayed-onset coronal suture synostosis (n = 78); rabbits with early-onset unilateral coronal suture synostosis (n = 32); and rabbits with early-onset bilateral coronal suture synostosis (n = 50). Epidural intracranial pressure measurements were obtained at 10, 25, 42, and 84 days of age using a NeuroMonitor microsensor transducer. Normal rabbits and rabbits with delayed-onset coronal suture and early-onset unilateral coronal suture synostosis showed a similar oscillating pattern of age-related changes in normal and head-down intracranial pressure from 10 to 84 days of age. In contrast, rabbits with early-onset bilateral coronal suture synostosis showed markedly elevated normal and head-down intracranial pressure levels from 10 to 25 days and showed a different pattern through 84 days. Results from one-way analysis of variance revealed significant (p < 0.01) group differences only at 25 days of age. Rabbits with early-onset bilateral coronal suture synostosis had significantly (p < 0.05) greater normal and head-down intracranial pressure (by 42 percent) than the other three groups. These results showed differing intracranial pressure compensations in rabbits with uncorrected multiple-suture synostosis compared with normal rabbits or rabbits with uncorrected single-suture synostosis, possibly through progressive cerebral atrophy and decreased intracranial volume, abnormal intracranial vascular patterns and blood volume, and/or differing cranial vault compensatory changes.

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Intracranial Volume in Craniosynostotic Rabbits

Cited by 23 publications

References 0 publications

Intracranial Volume Changes in Craniosynostotic Rabbits: Effects of Age and Surgical Correction

Intracranial Volume Changes in Craniosynostotic Rabbits: Effects of Age and Surgical Correction

Rescue of coronal suture fusion using transforming growth factor‐beta 3 (Tgf‐β3) in rabbits with delayed‐onset craniosynostosis

Intracranial Pressure Changes in Craniosynostotic Rabbits

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