Intracranial self-stimulation to the lateral hypothalamus, a memory improving treatment, results in hippocampal changes in gene expression

Huguet, Gemma; Aldavert-Vera, Laura; Kádár, Elisabet; Ortı́z, Sandra Peña de; Morgado-Bernal, Ignacio; Segura-Torres, Pilar

doi:10.1016/j.neuroscience.2009.04.074

Cited by 40 publications

(31 citation statements)

References 93 publications

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“…It also modulates expression of genes involved in learning and memory and in neural plasticity and neurogenesis in the hippocampus. 44 Expression of immediate early gene Nurr1, a transcription factor expressed in dopaminergic cells, was significantly increased in CA1, CA3, dentate gyrus, dorsal striatum, and lateral hypothalamus after intracranial self-stimulation. 1 Stimulation upregulates expression of genes involved in neurogenesis in the hippocampus.…”

Section: Medial Forebrain Bundlementioning

confidence: 99%

Neuromodulation for restoring memory

Bick¹,

Eskandar²

2016

FOC

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Disorders of learning and memory have a large social and economic impact in today's society. Unfortunately, existing medical treatments have shown limited clinical efficacy or potential for modification of the disease course. Deep brain stimulation is a successful treatment for movement disorders and has shown promise in a variety of other diseases including psychiatric disorders. The authors review the potential of neuromodulation for the treatment of disorders of learning and memory. They briefly discuss learning circuitry and its involvement in Alzheimer disease and traumatic brain injury. They then review the literature supporting various targets for neuromodulation to improve memory in animals and humans. Multiple targets including entorhinal cortex, fornix, nucleus basalis of Meynert, basal ganglia, and pedunculopontine nucleus have shown a promising potential for improving dysfunctional memory by mechanisms such as altering firing patterns in neuronal networks underlying memory and increasing synaptic plasticity and neurogenesis. Significant work remains to be done to translate these findings into durable clinical therapies.

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Section: Medial Forebrain Bundlementioning

confidence: 99%

Neuromodulation for restoring memory

Bick¹,

Eskandar²

2016

FOC

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“…DBS in central thalamus could lead to a complicated situation in arousal, behavior, and cognition [149][150][151]. With regard to the lateral hypothalamus, the post-training ICSS (the intracranial self-stimulation) could enhance the hippocampus-dependent memories via improving molecular and cellular mechanisms associated with synaptic plasticity, neurogenesis, and neuroprotection [152][153][154][155].…”

Section: Other Brain Regionsmentioning

confidence: 99%

Chemical and Physical Approaches for the Treatment of Alzheimer's Disease

Li¹,

Zhou²,

Wu³

et al. 2015

ADMET DMPK

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“…Segura-Torres and colleagues studied the effects of LH ICSS on hippocampal (51) and amygdalar (52) gene expression (90 min and/or 4.5 h after ICSS). c-Fos immunolabeling revealed increased activity in the amygdala, pyramidal layer (CA3), and granule cell layer (DGmb and DGlb).…”

Section: Translational Studiesmentioning

confidence: 99%

“…c-Fos immunolabeling revealed increased activity in the amygdala, pyramidal layer (CA3), and granule cell layer (DGmb and DGlb). The hippocampal cell labeling varied in intensity, signifying that ICSS leads to activation of gene transcription in distinct cells (51). In spite of unilateral stimulation, the neurochemical effects were predominantly bilateral.…”

Section: Translational Studiesmentioning

confidence: 99%

“…In spite of unilateral stimulation, the neurochemical effects were predominantly bilateral. In both stimulated regions, hippocampus and amygdala, increased expression of COX-2 gene which is related to neurite outgrowth and neurogenesis was observed (51, 52). Furthermore, genes related to protein folding (Hspa1a), neurite outgrowth and neurogenesis (Ret), neuroprotection (Hspa1a, Ret, Dnajb1), and anti-apoptosis (Hspa1a, Ret, Dnajb1, Fkbp5) were upregulated in both regions.…”

Section: Translational Studiesmentioning

confidence: 99%

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Deep Brain Stimulation as a Tool for Improving Cognitive Functioning in Alzheimer’s Dementia: A Systematic Review

et al. 2013

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Deep brain stimulation (DBS) is an established, in selected cases therapeutically effective, non-lesional treatment method delivering current rectangular pulses into dysfunctional brain structures via chronically implanted stimulation electrodes. DBS is a recognized method applied in movement disorders and is increasingly evaluated as a possible therapeutic option for psychiatric diseases such as refractory obsessive-compulsive disorders, Gilles de la Tourette syndrome, major depression, and substance-related addiction. Latest research indicates that DBS may be a method for improving cognitive functions in Alzheimer’s dementia (AD). Translational data in healthy and AD animals appear to support this notion. Nevertheless, many aspects remain unclear, particularly with regard to the optimal target structure. The objective of this review is to present a systematic overview regarding published research on DBS and cognitive functioning in animal and human studies as well as to provide a systematic overview of the feasibility and efficacy of the treatment. We describe three studies investigating the effects of DBS in patients with dementia, using either the fornix or the nucleus basalis of Meynert (NBM) as a target. In total, we identified 25 animal studies with 10 brain structures being targeted: fornix, NBM, anterior caudate nucleus, dorsal striatum, anterior thalamic nucleus, midline thalamic nuclei, central thalamus, lateral hypothalamus, hippocampus (entorhinal cortex, perforant path), and amygdala. Considering the wide and diverse spectrum of targets, we add to this review a supposition about possible underlying mechanisms of operation and recommendations for further research.

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Intracranial self-stimulation to the lateral hypothalamus, a memory improving treatment, results in hippocampal changes in gene expression

Cited by 40 publications

References 93 publications

Neuromodulation for restoring memory

Neuromodulation for restoring memory

Chemical and Physical Approaches for the Treatment of Alzheimer's Disease

Deep Brain Stimulation as a Tool for Improving Cognitive Functioning in Alzheimer’s Dementia: A Systematic Review

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