Intracranial self-stimulation site specificity: The myth of current spread

Steiner, Solomon S.; Bodnar, Richard J.; Nelson, William T.; Ackermann, Robert F.; Ellman, Steven J.

doi:10.1016/0361-9230(78)90102-8

Cited by 21 publications

(4 citation statements)

References 35 publications

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“…This issue will be discussed in more detail at the end of this paper. In the forebrain, self-stimulation was supported at moderate to high rates in the lateral hypothalamic MFB and zona incerta, the perifornical lateral hypothalamus, and the habenula and its efferent pathway, the fasciculus retroflexus (Huang and Routtenberg, 1971;Steiner et al, 1978;Sutherland and Nakajima, 1981).…”

Section: The Extended Amygdala As An Interface Between Amygdaloid Andmentioning

confidence: 98%

“…Mid-and hindbrain structures supporting robust selfstimulation included the ventral tegmental area, substantia nigra, retrorubral fields, central grey and dorsal raphe, dorsal tegmentum, including particularly the lateral dorsal tegmentum, the pedunculopontine tegmentum, the locus coeruleus and neighboring mesencephalic root of the trigeminal nerve, the motor nucleus of the trigeminal nerve, parabrachial nucleus, and select areas of the cerebellum (Ball et al, 1974;Crow et al, 1972;Huang and Routtenberg, 1971;Liebman et al, 1973;Ritter and Stein, 1974;Routtenberg and Malsbury, 1969;Simon et al, 1975;Steiner et al, 1978;van der Kooy and Phillips, 1979). Several of these investigations also revealed robust self-stimulation in or very near to the ventral tegmental decussation and anterior decussation of the superior cerebellar peduncle (Routtenberg and Malsbury, 1969;Liebman et al, 1973;Ritter and Stein, 1974) suggesting the possibility of interhemispheric connections in brain reward circuitry.…”

Section: The Extended Amygdala As An Interface Between Amygdaloid Andmentioning

confidence: 99%

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The central extended amygdala network as a proposed circuit underlying reward valuation

Waraczynski

2006

Neuroscience & Biobehavioral Reviews

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Section: The Extended Amygdala As An Interface Between Amygdaloid Andmentioning

confidence: 98%

Section: The Extended Amygdala As An Interface Between Amygdaloid Andmentioning

confidence: 99%

The central extended amygdala network as a proposed circuit underlying reward valuation

Waraczynski

2006

Neuroscience & Biobehavioral Reviews

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“…The pole of each bipolar electrode which elicited the higher peak response rates at the lowest intensity in this preliminary screen (Steiner, Bodnar, Nelson , Ackermann, & Ellman, 1978) served as the cathode for the rema inder of the experiment and either the other pole of the same bipolar electrode or a cortical screw served as the anode . For each electrode site, the lowest intensity was chosen which yielded consistently high response rates at a C-C interval of 10.0 msec and a CoT interval of 5.0 msec, but only operant responding if the T pulses were omitted.…”

Section: Methodsmentioning

confidence: 99%

Differential locus coeruleus and hypothalamic self-stimulation interactions

Bodnar¹,

Ellman

Coons

et al. 1979

Psychobiology

Self Cite

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To ascertain the nature of intracranial self-stimulation (ICSS) interactions between locus coeruleus (LC) and various hypothalamic (HYP) sites, rats were tested with monophasic pulse pair stimulation. When trains of pulse pairs were delivered to a single ICSS site , lower responding occurred at short pulse-pair intervals. However, when the pulses of each pulse pair were split between LC and HYP ICSS sites, response rates at all pulse-pair intervals were elevated well above single-pulse responding, indicating a neurophysiological interaction between these loci. The symmetry of LC and HYP interactions depended upon the HYP electrode placement. Both internal capsule and fields of Forel placements produced asymmetrical LC·HYP interactions in which higher ICSS rates occurred when the LC received the first pulse of each pair than when it received the second pulse of each pair, suggesting a direct, and possibly modulating, influence of the LC upon these HYP placements. Both medial forebrain bundle and perifornical HYP placements produced symmetrical LC·HYP interactions in which similar ICSS rates occurred regardless of site stimulation order, suggesting an indirect, reciprocal influence between the LC and these HYP placements.Theories of intracranial self-stimulation (lCSS) behavior have often questioned whether the many discrete rreuroanatomical loci throughout the brain which subserve the behavior are linked to form an integrated "reward" system or if these loci are independent of one another and only share the common property of ICSS. Among the many means of ascertaining whether ICSS loci form an integrated system is to determine whether stimulation delivered to pairs of ICSS sites will summate and cause increased lCSS responding. Previous studies demonstrated that response rates elicited under simultaneous or nearsimultaneous stimulation of two ICSS sites were significantly greater than the sum of the response rates elicited when each of the sites was stimulated singly, suggesting that a behavioral interaction between the Data collection and analy sis was supported by a CCNY Faculty

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“…Values of SI range from 1.0 (maximum facilitation of aggression) through 0.0 (no effect of stimulation) to -1.0 (maximum inhibition of aggression). Pilot studies had shown that there was often a marked difference in effects in a given hamster, depending on which electrode tip was used as the leading pulse cathode (sensitivity to cathode choice has been reported in other brain-stimulation studies; Bodnar, Steiner, Brutus, Ippolito, & Ellman, 1978;Steiner et al, 1978). We therefore determined which tip was the more effective cathode for each hamster using a pulse amplitude of 100 (iA.…”

Section: Si =mentioning

confidence: 98%

Brief, high-frequency stimulation of the corticomedial amygdala induces a delayed and prolonged increase of aggressiveness in male Syrian golden hamsters.

Potegal

Hebert

DeCoster

et al. 1996

Behavioral Neuroscience

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Brief 200-Hz stimulation of the corticomedial amygdala (CMA) increases the aggressiveness of male Syrian golden hamsters for about 30 min; the effect peaks 10-15 min after stimulation. This effect is sensitive to stimulation amplitude and frequency. Stimulation at the parameters that reduce attack latency increases flank marking but does not affect copulation latency or general activity. Immunocytochemical analysis suggests that stimulation effects may be coupled to c-fos expression and that unilateral stimulation has bilateral effects. CMA stimulation effects appear to mimic part of the time course of behaviorally induced attack priming. The temporal persistence of aggression may result from long-term potentiation-like changes within CMA-related neural circuitry.

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Intracranial self-stimulation site specificity: The myth of current spread

Cited by 21 publications

References 35 publications

The central extended amygdala network as a proposed circuit underlying reward valuation

The central extended amygdala network as a proposed circuit underlying reward valuation

Differential locus coeruleus and hypothalamic self-stimulation interactions

Brief, high-frequency stimulation of the corticomedial amygdala induces a delayed and prolonged increase of aggressiveness in male Syrian golden hamsters.

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