Intracranial Rosai-Dorfman disease mimicking multiple meningiomas in a child: a case report and review of the literature

Tian, Yongji; Wang, Junmei; Ge, Jin zhao; Ma, Zhenyu; Ge, Ming

doi:10.1007/s00381-014-2536-y

Cited by 18 publications

(33 citation statements)

References 41 publications

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“…A total of about 219 patients with CNS RDD (including our case) have been reported in literature so far. [ 9 – 12 ] CNS manifestation of RDD was reported in 180 cases while 39 cases had a systemic disseminated manifestation of the disease (Table 1 ). Furthermore, CNS manifestation of the disease has been reported in both adults and children with a male prevalence (M/F ratio: 1.8:1.0).…”

Section: Discussionmentioning

confidence: 99%

“…Microscopic examination revealed chronic inflammation with infiltrate of histiocytes, lymphocytes, and plasma cells in the fibrous stroma. [ 12 ] Emperipolesis exhibits that the majority of histiocytes contains well-preserved lymphocytes within their cytoplasm. The histiocytes react positively with S-100 protein and CD68 but negatively with GFAP and EMA.…”

Section: Discussionmentioning

confidence: 99%

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Isolated intracranial Rosai–Dorfman disease mimicking petroclival meningioma in a child

et al. 2017

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Rationale:Rosai –Dorfman disease (RDD) is a rare, idiopathic, and non-neoplastic histioproliferative disease with distinctive entity of unknown etiology. Central nervous system (CNS) RDD is uncommon, hence, isolated intracranial RDD is extremely rare. So far only 6 cases of CNS RDD with the lesions originating from petroclival region have been reported. We present a case of isolated intracranial RDD mimicking petroclival meningioma.Patient concerns:A 14-year-old girl was admitted at our hospital with a 3-month history of dizziness, slowly progressing headache, and 2-month history of instability in walking. Cranial nerve deficits, including left facial paralysis, left facial numbness and left hearing loss, were evident on examination.Diagnoses:Initial diagnosis of petroclival meningioma was made according to preoperative magnetic resonance imaging.Interventions:The lesion was resected subtotally and pathology confirmed RDD. The patient received gamma-knife treatment for the residual lesion.Outcomes:The patient recovered well and the residual lesion significantly retrogressed on follow-up images.Lessons:Preoperative diagnosis of petroclival RDD is full of challenges. Although surgical resection of lesions is an effective treatment option, total resection is not highly recommended because the surgery-related defect must be minimal. Patient with residual lesion can be put on steroid therapy and/or radiotherapy, especially for IgG4 positive subset of RDD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Isolated intracranial Rosai–Dorfman disease mimicking petroclival meningioma in a child

et al. 2017

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“…Clinical presentation and radiological findings of extranodal intracranial disease is similar to meningioma, sarcoma, inflammatory pseudotumor, or Langerhans histiocytosis [24]. The majority present with an isolated lesion [30]. The disease may remain extranodal and localized for years.…”

Section: Localization and Clinical Features Of Extranodal Intracraniamentioning

confidence: 99%

“…Treatment modalities include surgery, steroids, radiation therapy, chemotherapy (either alone or in combination), and even observation in case of exclusion an extranodal involvement [1,38]. Surgical treatment of RDD is indicated for extranodal forms of disease that are affecting vital structures; however, remissions with surgery alone have been reported in CNS-only disease [14,30]. Total resection of the intracranial lesion may be curative [3,20].…”

Section: Treatment Of Extranodal Intracranial Rddmentioning

confidence: 99%

Extranodal Intracranial Rosai-Dorfman-Destombes Disease in Children: a Literature Review

Trbojević¹,

Marić

Barišić

2020

SN Compr. Clin. Med.

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Rosai-Dorfman-Destombes (RDD) disease also known as sinus histiocytosis with massive lymphadenopathy is a rare disease characterized by disorder of histiocytes within lymph nodes or other affected tissues. Extranodal forms of disease are even more uncommon. Only small percent of patients present with intracranial extranodal form of disease. Lesion biopsy and characteristic histopathological findings are crucial for definitive diagnosis. Histological findings typically show emperipolesis of affected histiocytes or hyperplastic lymph node sinuses containing enlarged histiocytes with phagocyted intact lymphocytes with specific immunoassay findings of the characteristic histiocytic non-Langerhans cells. Therapy includes various modalities such as surgery, steroids, radiotherapy, and/or chemotherapy. In case of extranodal intracranial form of disease, resection (single or combined with other treatment) was reported as effective. There are only few cases of extranodal intracranial disease in pediatric population described in the world so far. We aimed to provide brief comprehensive review of published cases referring on pediatric extranodal intracranial RDD.

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“…Osseous disease often manifests with lytic lesions (Fig 22). CNS lesions are extremely rare and may mimic meningiomas (80,82). Abdominal and pelvic organ involvement is also very uncommon.…”

Section: Rosai-dorfman Diseasementioning

confidence: 99%

Imaging of Histiocytosis in the Era of Genomic Medicine

et al. 2019

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■ Describe the novel genomic discoveries of histiocytosis and their implications for radiologic interpretation and patient management. ■ Discuss the role of imaging in diagnosing and monitoring histiocytosis in the new era of precision medicine approaches for treatment. ■ Recognize the imaging characteristics of common and uncommon subtypes of histiocytosis with a focus on adult-onset cases.

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Intracranial Rosai-Dorfman disease mimicking multiple meningiomas in a child: a case report and review of the literature

Cited by 18 publications

References 41 publications

Isolated intracranial Rosai–Dorfman disease mimicking petroclival meningioma in a child

Isolated intracranial Rosai–Dorfman disease mimicking petroclival meningioma in a child

Extranodal Intracranial Rosai-Dorfman-Destombes Disease in Children: a Literature Review

Imaging of Histiocytosis in the Era of Genomic Medicine

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