Intracranial Pressure Monitoring—Review and Avenues for Development

Harary, Maya; Dolmans, Rianne G F; Gormley, William B.

doi:10.3390/s18020465

Cited by 120 publications

(113 citation statements)

References 105 publications

Supporting

Mentioning

110

Contrasting

Unclassified

Order By: Relevance

“…Figure 2(b) shows model predictions of the average ICP versus time for a specified set of model parameters (γ = 1, v = 0.01, ρ = 0.1), and it is observed to be in good qualitative agreement with the behavior of ICP as expected from the Langfitt curve. We in [29] and Figure 2 in [30]. As intracranial volume increases with time, due to a growing tumor within the cranial vault, the compensatory mechanisms that avoid an initial rise in ICP are exhausted.…”

Section: Parameter Values and Functional Formsmentioning

confidence: 99%

A Biomechanical Model of Tumor-induced Intracranial Pressure and Edema in Brain Tissue

Sorribes¹,

Byrne

Moore³

et al. 2018

Preprint

View full text Add to dashboard Cite

Brain tumor growth and tumor-induced edema result in increased intracranial pressure (ICP), which, in turn, is responsible for conditions as benign as headaches and vomiting, or as severe as seizures, neurological damage, or even death. Therefore, it has been hypothesized that tracking ICP dynamics may offer improved prognostic potential in terms of early detection of brain cancer and better delimitation of the tumor boundary. However, translating such theory into clinical practice remains a challenge, in part, due to an incomplete understanding of how ICP correlates with tumor grade. Here, we propose a multiphase mixture model that describes the biomechanical response of healthy brain tissue -in terms of changes in ICP and edema -to a growing tumor. The model captures ICP dynamics within the diseased brain and accounts for the ability/inability of healthy tissue to compensate for this pressure. We propose parameter regimes that distinguish brain tumors by grade thereby providing critical insight into how ICP dynamics vary by severity of disease. In particular, we offer an explanation for clinically observed phenomena such as lack of symptoms in low grade glioma patients versus a rapid onset of symptoms in those with malignant tumors. Our model also takes into account the effects tumor-derived proteases may have on ICP levels and extent of tumor invasion. This work represents an important first step towards understanding the mechanisms that underlie the onset of edema and ICP in cancer-afflicted brains. Continued modeling effort in this direction has the potential to make an impact in the field of brain cancer diagnostics.

show abstract

Section: Parameter Values and Functional Formsmentioning

confidence: 99%

A Biomechanical Model of Tumor-induced Intracranial Pressure and Edema in Brain Tissue

Sorribes¹,

Byrne

Moore³

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…There are several techniques to measure and monitor ICP. Most conventional ICP measurement methods are invasive catheter-based procedures [5]. A number of clinical complications are encountered with catheterbased methods, such as infection and hemorrhage [6].…”

Section: Introductionmentioning

confidence: 99%

The development of a wireless LCP-based intracranial pressure sensor for traumatic brain injury patients

Sattayasoonthorn¹,

Suthakorn²,

Chamnanvej³

2020

IJECE

View full text Add to dashboard Cite

Raised intracranial pressure (ICP) in traumatic brain injury (TBI) patients can lead to death. ICP measurement is required to monitor the condition of a patient and to inform TBI treatment. This work presents a new wireless liquid crystal polymer (LCP) based ICP sensor. The sensor is designed with the purpose of measuring ICP and wirelessly transmitting the signal to an external monitoring unit. The sensor is minimally invasive and biocompatible due to the mechanical design and the use of LCP. A prototype sensor and associated wireless module are fabricated and tested to demonstrate the functionality and performance of the wireless LCP-based ICP sensor. Experimental results show that the wireless LCP-based ICP sensor can operate in the pressure range of 0 - 60.12 mmHg. Based on repeated measurements, the sensitivity of the sensor is found to be 25.62 µVmmHg-1, with a standard deviation of ± 1.16 µVmmHg-1. This work represents a significant step towards achieving a wireless, implantable, minimally invasive ICP monitoring strategy for TBI patients.

show abstract

“…In the literature, there is a strong recommendation with moderate quality of evidence that ICP and cerebral perfusion pressure should be used as a part of protocol-driven care in patients who are at risk of elevated ICP based on clinical and/or imaging features [1]. The fundamental principles of raised ICP are condensed in the Monro-Kellie doctrine, in which the volume of the intracranial cavity is constant under normal conditions and the maintenance of a steady ICP depends on the volume of the intracranial contents (brain tissue, blood, and cerebrospinal fluid) [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, intracranial compliance (ICC) or its inverse-intracranial elastancehas been studied for decades in an attempt to complement ICP interpretation and describe brain homeostasis more precisely, thus helping the neurocritical care team to anticipate brain function deterioration [6,7]. ICC has been found to be related to the compensatory mechanisms used to maintain ICP's stability [4]-for example, the higher the compensation, the higher the compliance of intracranial content to adapt to changes in volume and pressure. However, ICC has not been properly translated to clinical practice and this has remained a critical technology gap in clinical neuroscience, probably because of the number of factors involved in it.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Intracranial compliance concepts and assessment: A scoping review protocol

Russo¹,

Ocamoto²,

Vilela³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Monitoring patients with acute brain injury is crucial in neurocritical care. Intracranial compliance (ICC) has been studied to complement the interpretation of intracranial pressure (ICP) and help the neurocritical care team to anticipate brain function deterioration. ICC has been found to be related to compensatory mechanisms that maintain the stability of ICP (e.g., the higher the compensation, the higher the compliance of intracranial content to adapt to changes in volume and pressure). However, ICC has not been properly translated to clinical practice and has remained a critical technology gap in clinical neuroscience. The objective of this study is to establish a protocol for a scoping review to map the key concepts of ICC in the literature. In addition, this study is designed to characterize the relationship between ICC and ICP, as well as systematically describe the outcomes that are used to assess ICC, considering both the invasive and noninvasive methods.Methods: The scoping review protocol will be conducted according to the Joanna Briggs Institute’s recommendation. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Reviews will be followed. Animals and humans are considered as the population to be investigated. No age criteria or health condition will be considered. ICC, as well as the relationship between ICC and ICP, will be considered as a core concept in this review. Information will be screened based on the context of neurocritical care. Several databases (PubMed, CINAHL, Web of Science, EMBASE, Epistemonikos, Grey Literature Report, clinical trial registries, and Cochrane Clinical Trials) will be searched to identify literature using a combination of keywords and descriptors, and there will be no restriction on the time frame. Data will be extracted systematically by the research team and the results will be summarized.Discussion: No systematic review has mapped the concepts of ICC and its relationship with ICP. Providing the key concepts of ICC and the methods of assessment might show its possible applications in clinical practice and the gaps in research.Systematic review registration: Currently, scoping review protocols are not eligible for registration in the International Prospective Register of Systematic Review database.

show abstract

Intracranial Pressure Monitoring—Review and Avenues for Development

Cited by 120 publications

References 105 publications

A Biomechanical Model of Tumor-induced Intracranial Pressure and Edema in Brain Tissue

A Biomechanical Model of Tumor-induced Intracranial Pressure and Edema in Brain Tissue

The development of a wireless LCP-based intracranial pressure sensor for traumatic brain injury patients

Intracranial compliance concepts and assessment: A scoping review protocol

Contact Info

Product

Resources

About