2017
DOI: 10.1113/jp274315
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Intracranial pressure in outer space: preparing for the mission to Mars

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Cited by 7 publications
(5 citation statements)
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“…Additional studies are needed to determine which aspects of spaceflight are responsible for photoreceptor damage and oxidative stress. Leading causes include radiation and possible alterations in intracranial pressure (ICP) or intraocular pressure (IOP) 60,61 induced by microgravity. It is possible that both space radiation and microgravity work in conjunction with one another to cause a more severe pathological result than either would in isolation.…”
Section: Discussionmentioning
confidence: 99%
“…Additional studies are needed to determine which aspects of spaceflight are responsible for photoreceptor damage and oxidative stress. Leading causes include radiation and possible alterations in intracranial pressure (ICP) or intraocular pressure (IOP) 60,61 induced by microgravity. It is possible that both space radiation and microgravity work in conjunction with one another to cause a more severe pathological result than either would in isolation.…”
Section: Discussionmentioning
confidence: 99%
“…The microgravity-induced redistribution of fluid to the upper part of the body has profound effects on multiple organs. For example, it leads to an elevation of intracranial pressure, which increases to greater levels than intraocular pressure, leading to a pressure gradient that is thought to be responsible for a frequently reported visual impairment 8 . Simultaneously, the reduction in gravitational force leads to significant changes in the vestibular system, leading to impaired balance, locomotion, eye-head-hand coordination as well as motion sickness within the first days of spaceflight 9 .…”
Section: Human Missions - the Physiological Contextmentioning
confidence: 99%
“…The microgravity-induced redistribution of fluid to the upper part of the body has profound effects on multiple organs. For example, it leads to an elevation of intracranial pressure, which increases to greater levels than intraocular pressure, leading to a pressure gradient that is thought to be responsible for a frequently reported visual impairment 8 .…”
Section: Human Missions -The Physiological Contextmentioning
confidence: 99%
“…For example, monitoring ICP during spaceflight is a topic of interest, with invasive measurements such as lumbar puncture currently not feasible inflight. Therefore, deployment of non-invasive devices to measure ICP is desirable ( 70 , 71 ). Otoacoustic Emission (OAE) phase change is a candidate non-invasive method to monitor ICP.…”
Section: Countermeasure Testing and Monitoring Development In Head-down Tilt Bed Restmentioning
confidence: 99%