Intracranial pressure and cerebrospinal fluid outflow conductance in healthy subjects

Albeck, Michael; Børgesen, S. E.; Gjerris, F.; Schmidt, J. F.; Sørensen, Per Soelberg

doi:10.3171/jns.1991.74.4.0597

Cited by 187 publications

(95 citation statements)

References 16 publications

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“…This person was a 45-year-old woman with bilateral papilledema of unknown origin, and had complaints of headache and symptoms of "mental insufficiency" for a period of 2 years after acute meningoencephalitis. Most subsequent authors 1,[5][6][7]12 have performed estimations of the ICP based on pressure measurements obtained by lumbar puncture. Some investigations were performed on healthy volunteers, while others included patients suspected of CSF dynamic disturbances, and subsequently were classified as "probably" normal.…”

Section: Discussionmentioning

confidence: 99%

Intracranial pressure following complete removal of a small demarcated brain tumor: a model for normal intracranial pressure in humans

Andresen¹,

Juhler²

2014

JNS

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Object. Current published normal values for intracranial pressure (ICP) are extrapolated from lumbar CSF pressure measurements and ICP measurements in patients treated for CSF pressure disorders. There is an emerging agreement that true normal ICP values are needed for diagnostic and therapeutic purposes. This study documents normal ICP in humans.Methods. In this study the authors included adult patients scheduled for complete removal of a solitary, clearly demarcated, small brain tumor. The mean age of these patients was 67 years old (range 58-85 years old). Exclusion criteria were intended to create a study population with as normal brains as possible. A new telemetric ICP monitoring device was implanted at the end of surgery and monitoring was conducted 2 and 4 weeks postoperatively.Results. In the supine position, mean ICP was 0.5 ± 4.0 mm Hg at 4 weeks postoperatively. Postural change to the standing position resulted in a decrease in mean ICP to −3.7 ± 3.8 mm Hg. These results show ICP to be considerably lower than previously estimated.Conclusions. This study provides a preliminary reference range for normal ICP in humans. It is the first study to show that ICP in the healthy human brain decreases to negative values when assuming the upright position. If these results are later confirmed in a larger series, they might provide reference values for diagnosis and treatment in patients with CSF-related disorders. New normal values also have implications for future shunt design and the ICP target range in hydrocephalus treatment.

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Section: Discussionmentioning

confidence: 99%

Intracranial pressure following complete removal of a small demarcated brain tumor: a model for normal intracranial pressure in humans

Andresen¹,

Juhler²

2014

JNS

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“…The non-linear vascular compliance is given by β = 2 as representative of the range 1 < β <3 given in the literature Jones et al, 2001Jones et al, ,2002Mandeville et al, 1999;Sheth et al, 2004b). Finally, P A =60 mmHg for the 30-μm arteriole blood pressure, P V =25 mmHg for the 35-μm venule blood pressure (Lipowsky, 2005), and the intracranial pressure, P IC =10 mmHg (Albeck et al, 1991;Alperin et al, 2000).…”

Section: Initial Conditions Related To Blood Flow and Volumementioning

confidence: 99%

A vascular anatomical network model of the spatio-temporal response to brain activation

Boas¹,

Jones²,

Devor³

et al. 2008

NeuroImage

198

240

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Neuronal activity-induced changes in vascular tone and oxygen consumption result in a dynamic evolution of blood flow, volume, and oxygenation. Functional neuroimaging techniques, such as functional magnetic resonance imaging, optical imaging, and PET, provide indirect measures of the neural-induced vascular dynamics driving the blood parameters. Models connecting changes in vascular tone and oxygen consumption to observed changes in the blood parameters are needed to guide more quantitative physiological interpretation of these functional neuroimaging modalities. Effective lumped-parameter vascular balloon and Windkessel models have been developed for this purpose, but the lumping of the complex vascular network into a series of arterioles, capillaries, and venules allows only qualitative interpretation. We have therefore developed a parallel vascular anatomical network (VAN) model based on microscopically measurable properties to improve quantitative interpretation of the vascular response. The model, derived from measured physical properties, predicts baseline blood pressure and oxygen saturation distributions and dynamic responses consistent with literature. Furthermore, the VAN model allows investigation of spatial features of the dynamic vascular and oxygen response to neuronal activity. We find that a passive surround negative vascular response ("negative BOLD") is predicted, but that it underestimates recently observed surround negativity suggesting that additional active surround vasoconstriction is required to explain the experimental data.

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“…But in this section, an injection test can not be done, considering morbidity of a surgical act on healthy people. Consequently, we design the cerebral SAS and cerebral ventricles compliances to obtain a pressure amplitude between 1 mmHg and 3 mmHg, that corresponds to physiological values [21,1].…”

Section: Healthy Casementioning

confidence: 99%

Numerical Modeling of the Intracranial Pressure using Windkessel Models

Garnotel¹,

Salmon²,

Balédent³

2017

MathS In A.

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The intracranial pressure (ICP) is an important factor in the proper functioning of the brain. This pressure is needed to be constantly regulated, since an abnormal elevation can be quite dangerous. In this article, we develop some numerical tools to better understand the regulation of this pressure. In particular, as it is impossible to measure the ICP in a non-invasive way, these numerical tools can allow to estimate values of the ICP. In addition, we propose to compute the dynamics of the cerebrospinal fluid (CSF), taking into account the connected environment of the skull and the arterio-venous flows. A computational fluid dynamics model in two dimensions is developed for the cerebrospinal fluid system, with Windkessel type boundary conditions. This model shows that the dynamics can impact the distribution of the CSF in the different compartments of the cerebrospinal system.

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Intracranial pressure and cerebrospinal fluid outflow conductance in healthy subjects

Cited by 187 publications

References 16 publications

Intracranial pressure following complete removal of a small demarcated brain tumor: a model for normal intracranial pressure in humans

Intracranial pressure following complete removal of a small demarcated brain tumor: a model for normal intracranial pressure in humans

A vascular anatomical network model of the spatio-temporal response to brain activation

Numerical Modeling of the Intracranial Pressure using Windkessel Models

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