Intracranial plasma cell granuloma: A report of four cases

Marc’hadour, F. Le; Fransen, Patrick; Labat-Moleur, F; Passagia, J.-G.; Pasquier, B

doi:10.1016/0090-3019(94)90077-9

Cited by 37 publications

(30 citation statements)

References 32 publications

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“…As described in the literature, plasma cell granuloma is a discrete, dura-based inflammatory mass with associated fibrosis (33)(34)(35)(36). We believe that many lesions previously reported as CNS plasma cell granulomas or inflammatory pseudotumors are, in fact, RDD-CNS.…”

Section: Discussionmentioning

confidence: 72%

Rosai-Dorfman Disease Isolated to the Central Nervous System: A Report of 11 Cases

et al. 2001

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Sinus histocytosis with massive lymphadenopathy, also known as Rosai-Dorfman Disease (RDD), is an idiopathic histiocytic proliferation affecting lymph nodes. Although extranodal involvement has been reported in diverse sites, central nervous system (CNS) manifestation, particularly in the absence of nodal disease is uncommon. We report 11 cases of RDD primary to the CNS without evidence of other sites of involvement. The cases included 7 males and 4 females ranging in age from 22 to 63 years (mean: 41 y). The patients presented with headaches, seizures, numbness, or paraplegia. Eight cases involved the cranial cavity and three cases, the spinal canal. Lesions were most often extra-axial and dura based. Only one presented in the CNS parenchyma. Histologically, the lesions consisted of variable numbers of pale-staining histocytes with emperipolesis often overshadowed by extensive lymphoplasmacytic infiltrates and fibrosis in the background. Special stains for organisms were negative. By immunohistochemical analysis, the characteristic histiocytes were positive for S100 protein and CD68 and negative for CD1a. Treatment consisted of surgical biopsy or excision. Follow-up, available for 10 cases with intervals ranging from 5 days to 42 months (mean: 15 mo), disclosed one patient dying of operative complications 5 days after biopsy and nine patients with no evidence of disease progression RDD should be considered in the differential diagnosis of inflammatory lesions of the CNS. Our study suggests that this entity may have been misdiagnosed in the past as plasma cell granuloma or inflammatory pseudotumor.

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Section: Discussionmentioning

confidence: 72%

Rosai-Dorfman Disease Isolated to the Central Nervous System: A Report of 11 Cases

et al. 2001

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“…7 Based on an ultrastructural study that revealed 25 ± 50 nm particles in the bronchial mucosa of aected patients, some authors have suggested that IPT is of viral origin, whereas others believe bacteria to be responsible due to the fact that antibiotics sometimes help to resolve IPT. 2,8 Despite these ®ndings, however, infection is seldom documented, and other investigators have suggested that pathologic conditions such as prior surgery at the aected site, trauma, or immune disturbances are involved. 2 The reaction that occurs could be one that is common to a particular organism, as in Whipple's disease, cat-scratch fever, or tuberculosis; however, the process might also re¯ect a host factor or defect, similar to what is seen in chronic granulomatous disease or certain hypersensitivity disorders.…”

Section: Discussionmentioning

confidence: 99%

“…2,8 Despite these ®ndings, however, infection is seldom documented, and other investigators have suggested that pathologic conditions such as prior surgery at the aected site, trauma, or immune disturbances are involved. 2 The reaction that occurs could be one that is common to a particular organism, as in Whipple's disease, cat-scratch fever, or tuberculosis; however, the process might also re¯ect a host factor or defect, similar to what is seen in chronic granulomatous disease or certain hypersensitivity disorders. Whatever site or system it aects, IPT should be considered a nonspeci®c response to immune or in¯ammatory disturbances, and a response that presumably involves multiple factors.…”

Section: Discussionmentioning

confidence: 99%

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Multiple plasma cell granuloma of the central nervous system: a unique case with brain and spinal cord involvement. Case report and review of literature

et al. 2002

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Study Design: Single subject (male, 34 years-of-age) case report. Objectives: To describe a unique case of plasma cell granuloma (PCG) with simultaneous brain and spinal cord involvement. Setting: Private hospital, capital city, Turkey. Methods: The patient presented with headache and paraplega. T2 weighted MR images showed multiple hyperintense cerebral, cerebellar, brainstem and spinal cord lesions that enhanced homogeneously with contrast medium. The patient was operated on, and the two intramedullary spinal cord lesions at T11 and T12 were totally excised. Results: After 3 months of an intense physiotherapy programme the patient was able to walk with help. Conclusion: We report for the ®rst time, the occurrence of multiple, simultaneous brain and intramedullary spinal cord plasma cell granulomas.

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“…28 Le Marc'hadour et al reported four cases of intracranial plasma cell granuloma with lesions located in the right cavernous sinus, the left cavernous sinus with extension to the tentorium cerebelli, the cerebellar vermis, and the pituitary stalk. 29 Makino et al reported a case of plasma cell granuloma of the left frontal lobe in an 11-year-old boy, who had a 2-month history of mild headache and nausea. 30 Buccoliero et al reported a case of intracranial plasma cell granuloma that involved the cranial base, frontal region, and extended to the floor of the third ventricle in a 70-year-old man who presented with progressive visual disturbance.…”

Section: Discussionmentioning

confidence: 99%

Immunoglobulin G4-positive Sclerosing Idiopathic Orbital Inflammation: New Neuro-ophthalmological Presentations

Al‐Zubidi¹,

Oku²,

Verner-Cole³

et al. 2013

Neuro-Ophthalmology

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Intracranial plasma cell granuloma: A report of four cases

Cited by 37 publications

References 32 publications

Rosai-Dorfman Disease Isolated to the Central Nervous System: A Report of 11 Cases

Rosai-Dorfman Disease Isolated to the Central Nervous System: A Report of 11 Cases

Multiple plasma cell granuloma of the central nervous system: a unique case with brain and spinal cord involvement. Case report and review of literature

Immunoglobulin G4-positive Sclerosing Idiopathic Orbital Inflammation: New Neuro-ophthalmological Presentations

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