Intracranial Myoepithelioma: A Case Report and Review of Literature

Gowripriya, G; Sridhar, K; Vij, Mukul

doi:10.4103/0028-3886.271273

Cited by 3 publications

(5 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[2,16] e occurrence of myoepithelial tumors within the central nervous system is also extremely rare, with only a few cases reported. [1,2,4,11] Most commonly these tumors present as benign myoepitheliomas, but malignant myoepithelial carcinomas have been known to metastasize to the lungs, bone, soft tissue, skin, liver, and brain. As reported by Ren et al, [15] the mean metastatic rate can reach 47% and mortality 29%.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Uncommon metastases to the brain: Frontal lobe myoepithelial carcinoma

Chong¹,

Wong-Achi²,

Pozo³

et al. 2023

Surgical Neurology International

View full text Add to dashboard Cite

Background: Myoepithelial tumors have been widely described as a rare form of salivary gland neoplasm, although currently soft-tissue phenotypes have also been identified. These are tumors composed entirely of myoepithelial cells that exhibit a dual epithelial and smooth muscle phenotype. The occurrence of myoepithelial tumors within the central nervous system is also extremely rare, with only a few cases reported. Treatment options include surgical resection, chemotherapy, radiotherapy, or a combination of these approaches. Case Description: The authors present a case of soft-tissue myoepithelial carcinoma with an unusual brain metastasis, rarely described in the literature. The purpose of this article is to present an update on the diagnosis and treatment of this pathology when affecting the central nervous system, through the review of the current evidence. Conclusion: However, despite complete surgical resection, there is about a significative high rate of local recurrence and metastasis. Careful patient follow-up and staging is essential for better characterization and understanding of this tumor’s behavior.

show abstract

Section: Discussionmentioning

confidence: 99%

“…[ 2 , 16 ] The occurrence of myoepithelial tumors within the central nervous system is also extremely rare, with only a few cases reported. [ 1 , 2 , 4 , 11 ]…”

Section: Discussionmentioning

confidence: 99%

Uncommon metastases to the brain: Frontal lobe myoepithelial carcinoma

Chong¹,

Wong-Achi²,

Pozo³

et al. 2023

Surgical Neurology International

View full text Add to dashboard Cite

show abstract

“…Rearrangements of the EWSR1 gene have been reported to be associated with myoepithelial tumors in soft tissue and other nonsalivary gland locations. [ 2 5 21 ] A subset of skin and soft-tissue myoepithelial tumors display frequent PLAG1 gene rearrangements and therefore appear to be genetically linked to their salivary gland counterparts. [ 21 22 ] For sporadic ACC, several comprehensive genomic studies have identified IGF2 overexpression, WNT pathway perturbations (CTNNB1 and ZNRF3 mutations), TP53 mutations, copy-number alterations including massive DNA loss and whole-genome doubling, and decreased telomere length.…”

Section: Discussionmentioning

confidence: 99%

“…Gender Site Positive markers Negative markers Gowripriya et al [5] 43 years Male Left Meckel's cave S-100, pancytokeratin, SMA, GFAP, vimentin, CK14, 34 betaE12, D240 NA Hayward et al [1] 17 years Female Right orbital apex S-100, keratin, SMA, p63, EMA Desmin Erdogan et al [6] 46 years Female Left frontal dura S-100, keratin, SMA, calponin, GFAP EMA, synaptophysin, chromogranin, p63, CD34 Hong et al [7]…”

Section: Agementioning

confidence: 99%

“…[ 2 3 4 ] Primary intracranial myoepithelial neoplasms are even rarer with only around nine cases reported [ Table 1 ]. [ 1 3 4 5 6 7 8 9 ] Extra-axial tumors contributed to the majority in this cohort. Due to the rarity of such a condition, it has been considered as an independent disease without association with other diseases.…”

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Coincidence of intracranial myoepithelioma and adrenocortical carcinoma in a young man

Tsang

2021

Asian J Neurosurg

View full text Add to dashboard Cite

Myoepithelial tumors are rare neoplasms that develop from myoepithelial cells in glandular structures and soft tissues. Primary intracranial myoepithelial neoplasms are even rarer with around ten cases reported. On the other hand, adrenocortical carcinoma (ACC) is also uncommon with an annual incidence of 0.7–2 per million and carries a poor prognosis. It is known to have an association with certain familial cancer syndromes. Even in sporadic cases, a significant portion of them had other malignancies before and after diagnosis of ACC. We reported a 34-year-old gentleman who was diagnosed to have ACC without known familial cancer syndrome. After that, he was also found to have right occipital myoepithelioma that was confirmed by excisional biopsy. There was no known association between these two pathologies. This is the first report of coincidence of ACC and intracranial myoepithelioma.

show abstract

Primary parasagittal myoepithelioma in a paediatric patient: review of the literature and illustrative case

2021

View full text Add to dashboard Cite

Myoepithelial tumours are a rare form of salivary gland neoplasm, and their occurrence in the central nervous system is exceedingly rare. The authors report the case of an 18-year-old Filipino man presenting with headache and weakness, and on imaging showing an extensive parasagittal tumour at the left posterior parietal area with extracalvarial extension. There was no systemic disease. The patient underwent surgery to excise the tumour, with histopathology showing findings consistent with myoepithelioma. There was no further treatment, given the benign histology of the lesion, but there was recurrence after 8 months. Repeat surgery was done for the patient and he is for adjuvant radiotherapy. This appears to be the 10th reported case of a central nervous myoepithelioma, and the first case in the Philippines of a primary parasagittal myoepithelioma in a paediatric patient. Further information is needed to provide diagnostic and therapeutic recommendations.

show abstract

Intracranial Myoepithelioma: A Case Report and Review of Literature

Cited by 3 publications

References 14 publications

Uncommon metastases to the brain: Frontal lobe myoepithelial carcinoma

Uncommon metastases to the brain: Frontal lobe myoepithelial carcinoma

Coincidence of intracranial myoepithelioma and adrenocortical carcinoma in a young man

Primary parasagittal myoepithelioma in a paediatric patient: review of the literature and illustrative case

Contact Info

Product

Resources

About