Intracranial metastatic prostate carcinoma presenting as intermittent double vision

Saito, Yuka; Kondo, Yukihiro; Shimizu, Hiroyuki; Kunimoto, Kenta; Nishimura, Taiji

doi:10.1016/j.urology.2004.04.073

Cited by 7 publications

(14 citation statements)

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“…Metastatic involvement of the pituitary and infundibular stalk is a rare occurrence (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Primary tumor histologic subtypes which have been documented to spread to the pituitary include lung cancer (NSCLC and SCLC), breast cancer, prostate cancer, renal cell carcinoma, and melanoma (among others), with lung cancer and breast cancer being the most frequently reported [4,5,7,13].…”

Section: Discussionmentioning

confidence: 99%

“…Primary tumor histologic subtypes which have been documented to spread to the pituitary include lung cancer (NSCLC and SCLC), breast cancer, prostate cancer, renal cell carcinoma, and melanoma (among others), with lung cancer and breast cancer being the most frequently reported [4,5,7,13]. Clinical presentations range from isolated diabetes insipidus, to visual loss or diplopia, to full-blown panhypopituitarism [3][4][5][6][7][8][9][10][11]13]. These presenting toxicities have been shown to resolve completely or partially in some but not all cases with acute surgical decompression (via trans-sphenoidal resection), radiation therapy, chemotherapy, and anti-hormonal therapy in the case of metastatic prostatic adenocarcinoma [1,3,7,11].…”

Section: Discussionmentioning

confidence: 99%

“…Clinical presentations range from isolated diabetes insipidus, to visual loss or diplopia, to full-blown panhypopituitarism [3][4][5][6][7][8][9][10][11]13]. These presenting toxicities have been shown to resolve completely or partially in some but not all cases with acute surgical decompression (via trans-sphenoidal resection), radiation therapy, chemotherapy, and anti-hormonal therapy in the case of metastatic prostatic adenocarcinoma [1,3,7,11]. Differentiation of a pituitary metastasis from a primary pituitary neoplasm (adenoma or carcinoma) can be difficult [4][5][6][7].…”

Section: Discussionmentioning

confidence: 99%

“…Involvement of the pituitary gland by metastatic disease is extremely rare, with most of the existing data based on individual case reports and literature reviews [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. We recently treated a patient with a prior history of colonic adenocarcinoma who presented postoperatively after transsphenoidal resection of an isolated metastatic lesion involving the sellar floor.…”

Section: Introductionmentioning

confidence: 99%

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Intracranial metastatic disease rarely involves the pituitary: retrospective analysis of 935 metastases in 155 patients and review of the literature

et al. 2010

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We present a case report of a patient recently treated at our institution for an isolated non-small cell lung cancer metastatic lesion to the sella, report the lack of involvement of the pituitary gland in a large single-institution series of treated intracranial parenchymal metastases, and review the pertinent literature. We reviewed cranial imaging studies (CT and MRI) for 935 metastases in 155 patients treated at our institution over the previous 3 years for intracranial metastatic disease. Special attention was paid to the skull base to document the presence of any metastatic disease involving the pituitary gland, infundibular stalk, sella turcica (including anterior and posterior clinoids), or diaphragm sellae. We found no other involvement of the pituitary gland or other sellar structures by metastatic disease in this series. Intracranial metastatic disease rarely involves the pituitary gland and infundibular stalk parenchyma, suggesting that this structure may be safely omitted from the treatment field during WBRT and prophylactic cranial irradiation (PCI). This treatment approach should reduce the late sequelae of treatment to this critical organ.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Intracranial metastatic disease rarely involves the pituitary: retrospective analysis of 935 metastases in 155 patients and review of the literature

et al. 2010

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“…However, while our review of the literature shows a few hundred cases of CSS reported, there are only a handful of cases that describe invasion of prostate cancer metastases into the cavernous sinus, specifically which are summarized in Table 1. [12][13][14][15][17][18][19][20][21][22] Prostate metastases to other regions of the skull base, such as the sphenoid sinus, clivus, or petrous bone, with various neuropathies have been described in just a Abir.…”

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confidence: 99%

Metastatic Prostate Cancer Manifesting as Cavernous Sinus Syndrome—Case Report and Review of the Literature

Kuiper¹,

Babikian²,

Delacruz³

2017

Oncology &Amp; Hematology Review (US)

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C avernous sinus syndrome (CSS) is a rare clinical entity which results in compression of the neurovascular structures in the cavernous sinus, potentially leading to headache, ophthalmoplegia, and neuropathy. The most common causes are tumor, trauma, inflammation, aneurysm, and infection. We report the case of an 82-year-old male with osseous-predominant metastatic prostate cancer who was admitted for intractable right-sided periorbital pain and diplopia. He also developed a headache with associated mild ptosis and weak cranial nerve (CN) VI function. He later developed complete right eye ptosis, complete CN VI paralysis, and palsies of CNs III and IV. Magnetic resonance imaging (MRI) of the sella turcica confirmed a distinct enhancing lesion in the cavernous sinus and he was diagnosed with CSS as a result of bony metastasis from his prostate cancer. He was started on high-dose steroids, and underwent directed radiation therapy. Bone metastasis is common with prostate cancer with predilection for more proximal structures such as the iliac bones and lumbar spine. Cases of CSS stemming from metastatic prostate cancer are rare. Thus, the development of CN palsy and ophthalmoplegia along with orbital pain should trigger a thorough investigation of the etiology of CSS which should include primary malignancies and metastasis from more distant structures such as the prostate. KeywordsCavernous sinus syndrome, cranial nerve palsy, ophthalmoplegia, metastatic prostate cancer Disclosure: Brandon Kuiper, Aline Babikian, and Wilfred Delacruz have nothing to disclose in relation to this article. No funding was received for the publication of this article.Authorship: All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship of this manuscript, take responsibility for the integrity of the work as a whole, and have given final approval to the version to be published.Compliance with Ethical Guidelines: All procedures were followed in accordance with the responsible committee on human experimentation and with the Helsinki Declaration of 1975 and subsequent revisions and informed consent was received from the patient involved in this case report.Open Access: This article is published under the Creative Commons Attribution Noncommercial License, which permits any noncommercial use, distribution, adaptation, and reproduction provided the original author(s) and source are given appropriate credit. Cavernous sinus syndrome (CSS) is a rare clinical entity characterized by headache, ophthalmoplegia, and neuropathy due to compression of vascular and nerve bundles that course through a narrow anatomical region in the skull.1,2 Myriad conditions lead to this syndrome including bacterial or fungal infection, thrombus, aneurysm, pituitary enlargement due to tumor or apoplexy, and primary or metastatic cancers.1-3 Prostate cancer has predisposition for bone metastasis, and bone is the predominant site of metastasis; however, skull involvement is less common. Metastatic prostate cancer in the...

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Hypopituitarism, a very rare manifestation of rectal cancer metastases: Case report and a review of the literature

Lin

Hung

et al. 2011

Clinics and Research in Hepatology and Gastroenterology

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Intracranial metastatic prostate carcinoma presenting as intermittent double vision

Cited by 7 publications

References 4 publications

Intracranial metastatic disease rarely involves the pituitary: retrospective analysis of 935 metastases in 155 patients and review of the literature

Intracranial metastatic disease rarely involves the pituitary: retrospective analysis of 935 metastases in 155 patients and review of the literature

Metastatic Prostate Cancer Manifesting as Cavernous Sinus Syndrome—Case Report and Review of the Literature

Hypopituitarism, a very rare manifestation of rectal cancer metastases: Case report and a review of the literature

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