Intracranial metastasis from a spinal cord primitive neuroectodermal tumor: Case report

Ogasawara, Hidenori; Kiya, Katsuzo; Kurisu, Kaoru; Muttaqin, Zainal; Uozumi, Tohru; Sakamoto, Kazuhiko; Kawamoto, Yukihiko; Iida, Koji

doi:10.1016/0090-3019(92)90158-j

Cited by 40 publications

(18 citation statements)

References 10 publications

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“…[315162139] However, few studies have examined the possible relationship between PNET and NF1 on the basis of their shared chromosome. [303544]…”

Section: Discussionmentioning

confidence: 99%

“…[25] Under normal conditions, the protein product of the NF1 gene (neurofibromin) controls cell division by inhibiting the Ras oncogene. [2535] In NF1, mutations produce either defective neurofibromin or insufficient quantities of neurofibromin- resulting in uncontrolled cell division. [25] Additionally, three exons in the NF1 gene are known to undergo alternative splicing- producing slightly different forms of neurofibromin.…”

Section: Discussionmentioning

confidence: 99%

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Intraspinal primitive neuroectodermal tumor in a man with neurofibromatosis type 1: Case report and review of the literature

Mulholland¹,

Barkhoudarian²,

Cornford³

et al. 2011

Surg Neurol Int

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Background:The occurrence of primitive neuroectodermal tumors (PNET) in patients with neurofibromatosis type 1 (NF1) has only been reported in two other cases in English-Language literature. Owing to the rarity of intraspinal PNET and the extremely high gene mutation variability in NF1, there is currently no conclusive evidence to suggest that PNET is associated with NF1. Here, we report a case of intradural PNET in a patient with NF1.Case Description:A 27-year-old male underwent a C1-C3 laminectomy for resection of an intramedullary mass. Histopathology and immunohistopathology analysis was performed. Microscopic examination and immunohistochemical staining indicated the mass was a primitive neuroectodermal tumor. Within 1 month after tumor resection, the patient developed leptomeningeal carcinomatosis. The patient was not a candidate for radiation therapy but underwent palliative systemic chemotherapy. He subsequently developed neutropenia and died 3 months after tumor resection.Conclusion:To our knowledge, this is the first reported intraspinal PNET associated with NF1. Genetic analysis of CNS PNETs suggests a possible correlation, but larger case series are needed to support this theory.

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“…[315162139] However, few studies have examined the possible relationship between PNET and NF1 on the basis of their shared chromosome. [303544]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Intraspinal primitive neuroectodermal tumor in a man with neurofibromatosis type 1: Case report and review of the literature

Mulholland¹,

Barkhoudarian²,

Cornford³

et al. 2011

Surg Neurol Int

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show abstract

“…Early onset of chemotherapy [22][23][24][25][26][27] in conjunction with radiation therapy may improve the survival time. However the prognosis of this disease is very poor and most patients develop local recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…The aggressive nature of the tumor is evidenced by rapid recurrence of the tumor in most of the reported patients. The cause of death in these patients included pneumonia, metastatic disease, aggressive local spread of the diseased, and progressive spinal cord involvement [17][18][19][20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Primary Intraspinal Primitive Neuroectodermal Tumor (PNET): A Rare Occurrence

Martin¹

2017

MOJCR

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“…Approximately 20 cases of pPNET have been reported and specific chromosomal translocations have been ascribed to genetic mechanisms. Only 12 cases of CNS PNET have been reported 1,2,4,5,7,11,12,13,15,16,18,19) and the genetic pathway is still unclear. A definite distinction between the two is critical for future molecular targeting therapy.…”

Section: Introductionmentioning

confidence: 99%

Central Nervous System Primitive Neuroectodermal Tumor of Spinal Cord Developing 20 Years After Curative Treatment of Pineal Tumor -Case Report-

Fujisawa

Kaneko

Tohma

et al. 2011

Neurol. Med. Chir.(Tokyo)

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A 65-year-old male who had previously received curative treatment for a pineal tumor presented with an extremely rare case of primary central nervous system (CNS) primitive neuroectodermal tumor (PNET) of the spinal cord manifesting as progressive tetraparesis. Although the histology was not verified, highly radiosensitive tumor was suspected because of the benign clinical course for over 20 years after only radiation therapy. Magnetic resonance imaging demonstrated an intramedullary tumor extending from C5 to T1. He underwent partial resection and histological examination revealed blue tumor with undifferentiated small round cells. Immunohistochemically, c-kit was negative but CD99 was strongly and diffusely positive. Therefore, rearrangement of the Ewing sarcoma gene was examined to determine the presence of peripheral type of PNET. The results were negative and systemic workup revealed no other disease. These findings led to the diagnosis of primary intramedullary CNS PNET of the spinal cord, and suggested that the spinal cord tumor occurred independently of the prior pineal disease. The residual tumor was controlled by postoperative local radiation therapy.

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Intracranial metastasis from a spinal cord primitive neuroectodermal tumor: Case report

Cited by 40 publications

References 10 publications

Intraspinal primitive neuroectodermal tumor in a man with neurofibromatosis type 1: Case report and review of the literature

Intraspinal primitive neuroectodermal tumor in a man with neurofibromatosis type 1: Case report and review of the literature

Primary Intraspinal Primitive Neuroectodermal Tumor (PNET): A Rare Occurrence

Central Nervous System Primitive Neuroectodermal Tumor of Spinal Cord Developing 20 Years After Curative Treatment of Pineal Tumor -Case Report-

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