Intracranial Meningiomas of Childhood and Adolescence

Tufan, Kadır; Doğulu, Fikret; Kurt, Gökhan; Emmez, Hakan; Çeviker, Necdet; Baykaner, M. Kemali

doi:10.1159/000084858

Cited by 70 publications

(57 citation statements)

References 38 publications

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“…The literature suggests that the incidence of pediatric meningiomas of the SB is lower than that of the NSB, and that SB meningiomas are more difficult to treat clinically. [3,12,16] In our study, however, the distribution was equal, with 6 meningiomas located in the SB and 6 in the NSB region. This discrepancy might be 6…”

Section: Discussioncontrasting

confidence: 68%

Surgical resection of pediatric skull base meningiomas

et al. 2012

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PURPOSE: Meningiomas in children are rare, especially those located at the skull base. In this study, we report our experience of meningioma surgery in the pediatric population and compare our findings of skull base (SB) versus non-skull base (NSB) meningiomas. METHODS: From our database of 724 surgically treated meningioma patients at the University Hospital, Zurich between 1995 and 2010, 12 patients under 18 years of age were identified. Data for those patients was retrospectively collected through chart review. A descriptive comparison between SB and NSB meningiomas was undertaken to determine statistical significance. RESULTS: In all 12 children (seven males, five females; mean age 12.2 ± 4.3 years), surgical removal of the meningioma was performed microsurgically with a mean follow-up of 53 months (range 12-137 months). Of the 12 tumors, six were located in the SB and six in the NSB. Comparing SB to NSB lesions, the mean age was 11 ± 3.8 versus 14 ± 4.6 years, male/female gender distribution was 5:1 compared to 1:5, mean tumor size was 7.5 ± 6.2 versus 26 ± 15.8 cm(2) (p = 0.03), and mean surgery time was 347 versus 214 min. While WHO grade was similar for both groups, the Simpson grade revealed more extensive resection for NSB meningiomas. The Glasgow Outcome Scale at last follow-up was favorable for both groups. CONCLUSIONS: Meningioma surgery was safe with favorable outcomes. SB meningiomas were significantly smaller in size, were less likely to undergo complete resection, and had a predilection for younger, male patients. Surgical Resection of Pediatric Skull Base Meningiomas Keywords:Pediatric meningiomas, skull base meningioma, neurosurgery, resection 2 AbstractPurpose Meningiomas in children are rare, especially those located at the skull base. In this study, we report our experience of meningioma surgery in the pediatric population and compare our findings of skull base (SB) versus non-skull base (NSB) meningiomas.Methods From our database of 724 surgically-treated meningioma patients at the University Hospital, Zurich between 1995 and 2010, 12 patients under 18 years of age were identified.Data for those patients was retrospectively collected through chart review. A descriptive comparison betweent SB and NSB meningiomas was undertaken to determine statistical significance.Results In all 12 children (7 males, 5 females; mean age 12.2 ± 4.3 years) surgical removal of the meningioma was performed microsurgically with a mean follow-up of 53 months (range 12-137 months). Of the 12 tumors, 6 were located in the SB and 6 in the NSB. Comparing SB to NSB lesions, the mean age was 11 ± 3.8 years versus 14 ± 4.6 years; male:female gender distribution was 5:1 compared to 1:5, mean tumor size was 7.5 ± 6.2 cm 2 versus 26 ± 15.8 cm 2 (p=0.03) and mean surgery time was 347 minutes versus 214 minutes. Whilst WHO grade was similar for both groups, the Simpson grade revealed more extensive resection for NSB meningiomas. The Glasgow outcome scale at last follow up was favorable for both groups.Conclusions...

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Section: Discussioncontrasting

confidence: 68%

Surgical resection of pediatric skull base meningiomas

et al. 2012

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“…Other grading systems exist, including the Mayo system based on similarly objective histological criteria but the WHO system is most accepted [16,17]. A higher percentage of meningiomas in patients under the age of 20 years are histologically atypical or anaplastic, and display an aggressive pattern of growth and recurrence [4][5][6][11][12][13]. Multiplicity of meningiomas and intraventricular and infratentorial meningiomas are also more common in the younger age groups [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have evaluated the demographics and clinical features of meningiomas in individuals under the age of 20 years [5][6][7][9][10][11][12][13]18]. This captures most meningiomas that occur as part of a familial syndrome or the rare sporadic meningioma in young individuals.…”

Section: Introductionmentioning

confidence: 99%

Intracranial meningiomas in individuals under the age of 30; Analysis of risk factors, histopathology, and recurrence rate

Prabhu¹,

Perry²,

Melian³

et al. 2014

Neurosci Discov

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Background: Intracranial meningiomas are rare in individuals under age 30 years. The purpose of this study was to analyze the demographics and clinical features of intracranial meningiomas in individuals under age 30 years. Methods: A retrospective analysis of clinical, radiographic, and pathology data of patients under age 30 years who presented with an intracranial meningioma was performed. Results: Thirty five patients met the criteria. Mean age was 25 years, 11 were male and 24 female. Five patients had previous radiation exposure. The presenting symptom was headache in 16 patients (45.7%) and seizure in 9 (25.7%). Cranial base tumors comprised 74%; 26% were supratentorial. Simpson grade 1 or 2 resection was achieved in 16 patients (48.5%); grade 3 or 4 resection was achieved in 17 patients (51.5%). Tumor pathologic grade was WHO grade I in 27 (77.1%), grade II in 6 (17.1%) and grade III in 2 patients (5.7%). Postoperative radiation therapy for tumor progression was administered in 13 patients. Radiographic follow-up was available in 26 patients at an average of 6.1 years after surgery; of these, 14 had no recurrence or progression of residual tumor while 12 had recurrence or progression. Recurrence was more common in patients with WHO grade II and III tumors and radiation-induced meningiomas. Recurrent tumors tended to have a higher WHO grade. Conclusion: In this group of intracranial meningiomas in individuals <30 years, ionizing radiation was a risk factor and tumors were more common in females. A higher percentage of WHO grade II and III tumors at presentation and recurrence was noted. Recurrent tumors were more common in patients with higher WHO grade and in radiation-induced meningiomas.

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“…They comprise only 0.4–4.1% of all pediatric age tumors and only 1.5–1.8% of all intracranial neoplasms in children [1]. In the literature, large series of pediatric meningiomas are uncommon and only a few studies have attempted to analyze the characteristics of these neoplasms in children and the biological differences in comparison to the adult counterparts [1,2,3,4]. We retrospectively analyzed the clinical, pathological and management profile of these tumors.…”

Section: Introductionmentioning

confidence: 99%

Pediatric Intracranial Meningiomas – Do They Differ from Their Counterparts in Adults?

et al. 2007

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Aim: Meningiomas are very rare in children comprising only 0.44.1% of pediatric age tumors and only 1.5–1.8% of all intracranial neoplasms. We analyzed the clinical, pathological and management profile of these rare tumors and elucidated their differences from meningiomas in adults. Methods: From 1990 to 2005, 33 patients belonging to the pediatric age group with intracranial meningiomas were treated in NIMHANS. Results: There were 19 male and 14 female children. The duration of symptoms ranged from 1 to 60 months. The study had a mean follow-up of 23.4 months. The commonest presenting symptoms were headache (90.9%) and visual disturbances (51.5%). Three patients had associated neurofibromatosis. Calcification was noticed in 22% of the tumors. Intraventricular meningiomas were the commonest (24.2%). Gross total or near total resection was possible in 22 out of 33 patients. Nine patients had reversible postoperative motor deficits. Fibrous meningioma was the commonest histological subtype (24.2%). Five patients had atypical or anaplastic subtypes. Adjuvant radiotherapy was administered in 4 patients. Six patients had recurrences and underwent surgery. Ten patients required either staged procedures or multiple surgeries for the recurrence/residual tumors. Conclusion: Pediatric meningiomas are rare tumors and differ from those in adults by their male predominance, atypical locations, higher rates of malignant subtypes, recurrence and association with neurofibromatosis. Surgical management is challenging because of atypical location.

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Intracranial Meningiomas of Childhood and Adolescence

Cited by 70 publications

References 38 publications

Surgical resection of pediatric skull base meningiomas

Surgical resection of pediatric skull base meningiomas

Intracranial meningiomas in individuals under the age of 30; Analysis of risk factors, histopathology, and recurrence rate

Pediatric Intracranial Meningiomas – Do They Differ from Their Counterparts in Adults?

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