Intracranial meningeal melanocytoma diagnosed using an interdisciplinary approach: a case report and review of the literature

Gamoh, Shoko; Tsuno, Takaya; Akiyama, Hironori; Kotaki, Shinya; Nakanishi, Tamaki; Tsuji, Kaname; Yoshida, Hiroaki; Shimizutani, Kimishige

doi:10.1186/s13256-018-1725-9

Cited by 10 publications

(6 citation statements)

References 11 publications

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“…[ 11 ] Due to a limited number of cases, it is difficult to calculate the incidence of such tumors. [ 4 ]…”

Section: Discussionmentioning

confidence: 99%

“…The symptoms that lead patients to consult a doctor can be extremely different, depending on the tumor location. [ 4 ] In their study, Keng-Liang et al reported 12 patients with meningeal melanocytoma and Nevus of Ota [ 12 ] thus every patient should have a complete dermatology examination. In the case of our patient, he was Nevus of Ota-free.…”

Section: Discussionmentioning

confidence: 99%

“…This tumor mostly affects women, it is often diagnosed at the age of 50 years old [10] yet, rare cases affect kids [11] . Due to a limited number of cases, it is difficult to calculate the incidence of such tumors [4] …”

Section: Discussionmentioning

confidence: 99%

“…[ 3 ] Due to the limited number of cases, it is difficult to calculate the incidence of such tumors. [ 4 ] They are mainly located at the sulci around the base of the brain and the upper cervical spinal cord [ 5 ] and they are highly recurrent. [ 6 ] So far, no guideline has been provided to treat such tumors.…”

Section: Introductionmentioning

confidence: 99%

“…Limas and Tio first reported a primary melanotic benign tumor of the meninges in 1972 [3] . Due to the limited number of cases, it is difficult to calculate the incidence of such tumors [4] . They are mainly located at the sulci around the base of the brain and the upper cervical spinal cord [5] and they are highly recurrent [6] .…”

Section: Introductionmentioning

confidence: 99%

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Nivolumab as adjuvant treatment for a spinal melanocytoma

et al. 2021

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Rationale: Meningeal melanocytoma is a rare benign melanocytic tumor of the central nervous system. We report for the first time a case of meningeal melanocytoma treated with immunotherapy. Patient concerns: A 70-year-old man with no medical history was admitted to the Emergency Room. He suffered from a motor and sensory deficit in his left lower limb and a bilateral upper arm neuralgia. Diagnoses: A contrast-enhanced magnetic resonance imaging (MRI) was performed. It showed a C7-T1 bleeding intramedullary tumor. Laminectomy was decided and performed. The results of the pathologic examination showed a melanocytic tumor harboring GNAQ mutation. Meningeal melanocytoma was the final diagnosis. Interventions: The patient was treated with 10 radiotherapy sessions and 6 cycles of nivolumab. A year later, the patient experienced neuralgia again with severe pain and an increasing sensory motor deficit. He underwent a second surgery that was incomplete. As the tumor kept growing, he received temozolomide. But the 6th cycle had to be interrupted due to bedsore infection in the hip area. Outcomes: Disease progression finally led to the patient's death 3 years after diagnosis. Lessons: This case report is the first about a patient with meningeal melanocytoma treated with immunotherapy. Treatment based on biomolecular mutations will probably change spinal melanocytoma therapeutic approach in the next few years.

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“…[ 11 ] Due to a limited number of cases, it is difficult to calculate the incidence of such tumors. [ 4 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nivolumab as adjuvant treatment for a spinal melanocytoma

et al. 2021

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Meningeal melanocytoma in the cerebellopontine angle: A rare case report and review of the literature

Dong

Xiao

et al. 2021

Oncology and Translational Medicine

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Primary meningeal melanocytoma (MM) in the cerebellopontine angle (CPA) region is an extremely rare neoplasm that originates from the melanocytes in the leptomeninges. These lesions are usually misdiagnosed as they mimic other common CPA lesions through their nonspecific presenting symptoms, signs, and radiological characteristics. Here, we report a 47-year-old Chinese female patient who presented with a 1-month history of the right-sided tongue numbness and 1-week history of the right-sided face numbness that had been worsening for 2 days. The tumor, in the right CPA region, showed a slight isointensity on T1-weighted image and mixed signal intensity on T2-weighted image. The clinical presentation, surgical treatment, and pathologic characteristics were determined. The tumor was microsurgically resected and gross-total resection was achieved. The tumor revealed a solid, capsulated, brown-black lesion. Immunohistochemistry showed that the tumor cells were positive for human melanoma black-45 (HMB-45), melanoma antigen (MelanA), S100, SOX10, and BRAF, confirming the final diagnosis of meningeal melanocytoma. Ultimately, no signs of radiological local recurrence were observed during the two-year follow-up. Collectively, meningeal melanocytoma is difficult to distinguish from common tumors in the CPA region before operation due to the lack of specificity in imaging and symptoms. Complete surgical resection is the best therapeutic option for this tumor. Although the tumor is commonly considered as a benign lesion, recurrence and metastasis are common, and pathogenesis remains unclear.

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