Intracranial Manifestations of Malignant Lymphoma

Abstract

Images Figs. 1-4

Surgical management of intracranial Hodgkin's disease.

“…Sparling, Adams, and Parker (1947) emphasized that it is mandatory to obtain histological confirmation of any suspected space-occupying lesion which may occur during the course of the disease, either at operation or necropsy, before accepting the lesion as being truly spaceoccupying. This was reiterated by John and Nabarro (1955). Using this criterion, we have been able to find only 22 well-documented cases of intracranial space-occupying Hodgkin's lesions in a review of the world literature.…”

“…She remained well three years later. John and Nabarro (1955) cited a 25-year-old man with Hodgkin's disease of four years' duration, which had been treated with local radiation and systemicnitrogen mustard.When headache, misty vision, and papilloedemasupervened, systemic nitrogen mustard produced transient improvement, but he was readmitted three months later and a mass of Hodgkin's tissue was partially excised from the right middle fossa, where it was attached to the dura and invading the posterior part of the right cerebral hemisphere. The patient recovered, and raised intracranial pressure did not recur before his death 14 months later, although he did have an episode of hiccoughing which responded to a two-day course of radiation directed to his medulla.…”

Hypothalamic Obesity in Acute Leukaemia

“…However, after the introduction of chemotherapy of acute leu kaemia, the development of neurological complications during a remission has been described in a relatively large number of cases (1,6,9,10,11,12,15,18,20). This phenomenon has usually been observed in children, because a remission is most frequently brought about in young patients.…”

Intracranial Hodgkin's disease shown by radioisotope scan.

“…Thus there was only one among 125 cases reported by John and Nabarro (1955). In the monograph by Williams, Diamond, Craver, and Parsons (1959) there were four among 1,992 cases.…”