Intracranial Low-Grade Fibromyxoid Sarcoma: Findings on Electron Microscopy and Histologic Analysis

Shimizu, Yu; Tsuchiya, Katsuhiro; Fujisawa, Hironori

doi:10.1016/j.wneu.2019.12.135

Cited by 3 publications

(6 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Primary mediastinal sarcomas are rarer than ever. To the best of the authors' knowledge and the literature search performed, only seven cases of primary mediastinal LGFMS have been reported [2][3][4][5][6][7], and this is an additional rare case of primary mediastinal LGFMS with typical histological findings, which was confirmed by immunohistochemical (IHC) stains [8].…”

Section: Introductionmentioning

confidence: 76%

Low-grade fibromyxoid sarcoma incidentally discovered as an asymptomatic mediastinal mass: a case report and review of the literature

et al. 2021

View full text Add to dashboard Cite

Background Low-grade fibromyxoid sarcoma (LGFMS) is a rare tumor characterized by bland histological features and aggressive clinical course. The most common anatomic locations of occurrence are the lower extremities, thorax, inguinal area, and upper limbs. Primary mediastinal sarcomas are even rarer. To the best of our knowledge, only seven cases of primary mediastinal LGFMS have been reported in the literature. Here, we report a case of primary mediastinal LGFMS. Case presentation A 26-year-old Pakistani man presented with fever and vomiting for the past 2 months. On a routine chest x-ray, a mediastinal mass was incidentally found. Computed tomography (CT) scan showed a large circumscribed lobulated soft tissue density mass lesion in an anterior mediastinum. Grossly, the resected mass measured 17.0 × 12.0 × 11.0 cm. The cut surface was gray white with a whorled-like appearance and foci of calcification and cystic changes. Histologically, a spindle cell lesion was seen with alternating myxoid and hyalinized areas. The shaped cells were arranged in bundles. Immunohistochemical staining showed positive reactivity patterns with MUC4 and focally for epithelial membrane antigen (EMA). The diagnosis was confirmed as LGFMS. The patient is free of symptoms and recurrence 22 months after the surgery. Conclusion In conclusion, we report a rare case of primary mediastinal LGFMS in a young male patient that was discovered incidentally. Our patient is on regular follow-up to look for evidence of recurrence as these tumors are prone to recurrences.

show abstract

Section: Introductionmentioning

confidence: 76%

Low-grade fibromyxoid sarcoma incidentally discovered as an asymptomatic mediastinal mass: a case report and review of the literature

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Electron microscopically, the tumor cells were rich in rough endoplasmic reticulum, and were surrounded by large amounts of collagen fibrils and Golgi apparatus. 24 The gold standard for localized renal pelvis cancer is nephroureterectomy with removal of the bladder cuff. Radical nephrectomy is the main strategy for the primary renal fibrosarcoma.…”

Section: Discussionmentioning

confidence: 99%

“…Electron microscopically, the tumor cells were rich in rough endoplasmic reticulum, and were surrounded by large amounts of collagen fibrils and Golgi apparatus. 24 …”

Section: Discussionmentioning

confidence: 99%

Primary Synchronous Ipsilateral Renal Fibrosarcoma and Renal Pelvic Carcinoma: A Case Report and Literature Review

Hua

Liu

2021

OTT

View full text Add to dashboard Cite

Renal fibrosarcoma is a rare tumor, with only a few cases reported so far, and simultaneous occurrence of ipsilateral renal fibrosarcoma and renal pelvic carcinoma in a patient is extraordinarily rare. A 66-year-old man admitted to our hospital with right renal percutaneous nephrostomy and recurrent fever. And the patient underwent laparoendoscopic nephrectomy and partial ureterectomy for pyonephrotic nonfunctioning kidneys. Postoperative pathology showed fibrosarcoma of right kidney and carcinoma of the renal pelvis. This is the first case of simultaneous occurrence of ipsilateral renal fibrosarcoma and renal pelvic carcinoma in a patient. The diagnosis of fibrosarcoma is one of ultimate immunohistologic exclusion, because there are no specific immunologic markers for fibroblasts. Electron microscopy combined with light microscopy and IHC is helpful for the case of renal fibrosarcoma which is difficult to diagnose. Clinically, radical nephrectomy is the main strategy for primary localized renal fibrosarcoma. At present, it is still necessary to carry out basic biology research to better understand etiology and therapeutical strategy of renal fibrosarcoma.

show abstract

“…No existen rasgos radiológicos definitivos que diferencien el sarcoma fibromixoide de bajo grado de otro tipo de fibrosarcomas, ya que se comportan como masas sólidas con grados variables de realce, necrosis o degeneración quística y hemorrágica"(3). Aunque son raros forman parte del diferencial de las lesiones con base dural (1).…”

Section: Los Sarcomas Intracranealesunclassified

“…El sarcoma fibromixoide de bajo grado es un tumor de origen mesenquimal de tejidos blandos; caracterizado por una apariencia histológica benigna, pero de agresivas características clínicas y metástasis frecuente (1). Fue descrita inicialmente por Evans en 1987 como un sarcoma raro, pero no fue hasta 1993 que él reportó una serie de 12 casos (2,3).…”

Section: Introductionunclassified

Sarcoma fibromixoide intracraneal primario de bajo grado: reporte de caso y revisión de la literatura.

León-Palacios

Casavilca‐Zambrano

et al. 2020

Rev Neuropsiquiatr

View full text Add to dashboard Cite

El sarcoma fibromixoide de bajo grado (LGFMS) es un tumor de tejidos blandos de origen mesenquimal. Los sarcomas son un grupo heterogéneo, que representa el 1% de todas las neoplasias. Los sarcomas primarios del sistema nervioso central (SNC) son raros y representan solo el 0,7% del total de sarcomas, con una incidencia estimada de 3 por cada 10 millones de personas por año. En este artículo, se describe el caso de una mujer de 59 años que presentó un sarcoma fibromixoide intracraneal de bajo grado, localizado en la región parietal derecha. Se discute el curso clínico, estudios de imágenes, características histopatológicas y tratamiento de este diagnóstico infrecuente y, por lo mismo, muy poco reportado. El diagnóstico definitivo se obtiene, ciertamente, mediante estudios histo- patológicos.

show abstract

Intracranial Low-Grade Fibromyxoid Sarcoma: Findings on Electron Microscopy and Histologic Analysis

Cited by 3 publications

References 16 publications

Low-grade fibromyxoid sarcoma incidentally discovered as an asymptomatic mediastinal mass: a case report and review of the literature

Low-grade fibromyxoid sarcoma incidentally discovered as an asymptomatic mediastinal mass: a case report and review of the literature

Primary Synchronous Ipsilateral Renal Fibrosarcoma and Renal Pelvic Carcinoma: A Case Report and Literature Review

Sarcoma fibromixoide intracraneal primario de bajo grado: reporte de caso y revisión de la literatura.

Contact Info

Product

Resources

About