Intracranial, Intra-parenchymal Capillary Hemangioma – Case Report –

Koga, Yuichiro; Hamada, Saori; Saito, Hisayasu; Akai, Takuya; Kuroda, Satoshi

doi:10.2176/nmccrj.cr.2019-0145

Cited by 8 publications

(11 citation statements)

References 25 publications

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“…The tightly packed vessels contain plump endothelial cells which can impart the appearance of solid growth in areas. In the neuropathologic setting, hemangiomas are usually intraosseous, involving the spine and less frequently the skull, but have also been reported in CNS parenchyma [91][92][93]. If a suspected hemangioma involves the CNS parenchyma, adequate sampling and immunohistochemical workup should be undertaken to exclude the presence of neoplastic stromal cells.…”

Section: Hemangiomamentioning

confidence: 99%

Neuropathologic features of central nervous system hemangioblastoma

Yoda¹,

Cimino

2022

J Pathol Transl Med

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Hemangioblastoma is a benign, highly vascularized neoplasm of the central nervous system (CNS). This tumor is associated with loss of function of the VHL gene and demonstrates frequent occurrence in von Hippel-Lindau (VHL) disease. While this entity is designated CNS World Health Organization grade 1, due to its predilection for the cerebellum, brainstem, and spinal cord, it is still an important cause of morbidity and mortality in affected patients. Recognition and accurate diagnosis of hemangioblastoma is essential for the practice of surgical neuropathology. Other CNS neoplasms, including several tumors associated with VHL disease, may present as histologic mimics, making diagnosis challenging. We outline key clinical and radiologic features, pathophysiology, treatment modalities, and prognostic information for hemangioblastoma, and provide a thorough review of the gross, microscopic, immunophenotypic, and molecular features used to guide diagnosis.

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Section: Hemangiomamentioning

confidence: 99%

Neuropathologic features of central nervous system hemangioblastoma

Yoda¹,

Cimino

2022

J Pathol Transl Med

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“…We have compiled a list of selected case reports of intracranial capillary hemangioma to give a sense of how our case compares to those in the literature (Table 1). The list is not exhaustive, as shown by other reports 4–7 . Other cases report intracranial capillary hemangioma found in the temporal region of an adult 5,7–12 .…”

Section: Discussionmentioning

confidence: 97%

“…The list is not exhaustive, as shown by other reports. [4][5][6][7] Other cases report intracranial capillary hemangioma found in the temporal region of an adult. 5,[7][8][9][10][11][12] There are only a few instances of intracranial capillary hemangiomas documented in older adults; very few of these are intra-axial capillary hemangiomas or capillary hemangiomas in the temporal lobe or show documented growth of the hemangioma over time 13 (Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, the present case is only the ninth case of intra-axial intracerebral capillary hemangioma reported in the literature. 4,10,11,[14][15][16][17] Okamoto et al explored the de novo development of an intracranial hemangioma occurring in an older adult. 13 This lesion, identified in an 82-year-old woman, was positive for CD31 and CD34, had a Ki67 index of 7%, and was negative for GFAP and EMA.…”

Section: Discussionmentioning

confidence: 99%

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Documented growth of an intracranial capillary hemangioma: A case report

et al. 2023

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Intracranial capillary hemangiomas in adults are rare, and diagnosis can be challenging. Hemangiomas, in general (and particularly in the skin), are more often noted in the pediatric population. Due to the lack of imaging undertaken in the presymptomatic phase, the literature provides few clues on the rate of growth of these unusual tumors. Therefore, we report a case of a 64‐year‐old man with a medical history of Lyme disease who presented with exhaustion and confusion. Imaging demonstrated an intra‐axial lesion with vascularity in the posterior right temporal lobe, raising the possibility of a glioma. Imaging two years prior revealed a very small lesion in the same location. The patient underwent a craniectomy, total resection of the lesion was completed, and his symptoms of confusion resolved. Biopsy revealed a capillary hemangioma composed of small vascular channels lined by endothelial cells and pericytes without smooth muscle. Features of glioma, vascular neoplasms or neuroborreliosis (cerebral Lyme disease) were not identified. Our case documents the growth over two years of a rare intracranial capillary hemangioma in an older adult male.

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“…Intracranial capillary hemangiomas can present as both intra-axial and extra-axial lesions. Extra-axial lesions are more common, with convexities, the middle cranial fossa, and cavernous sinuses as their most prominent locations [ 10 , 11 ]. Contrary to typical capillary hemangiomas involving the skin and/or soft tissues, intracranial lesions are diagnosed in both infants and adults.…”

Section: Discussionmentioning

confidence: 99%