Intracranial Hypertension and Iron-Deficiency Anemia

Capriles, Luis F.

doi:10.1001/archneur.1963.00460080057008

Cited by 38 publications

(13 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[43] reported anemia in 15 of 96 patients who presented with clinical intracranial hypertension. Many types of anemia have been associated with intracranial hypertension, including hemolytic anemia,[49] aplastic anemia,[19253033] sickle cell anemia,[16] iron-deficiency anemia,[82141] anemia secondary to paroxysmal nocturnal hemoglobinuria,[1] and pernicious anemia. [38] In addition to optic disc edema, other ocular findings in patients with anemia include cotton wool spots, nerve fiber layer/preretinal hemorrhages, vitreous hemorrhages, and central retinal vein occlusion.…”

Section: Discussionmentioning

confidence: 99%

Unusual causes of papilledema: Two illustrative cases

Nguyen

Haider²,

Ackerman³

2013

Surg Neurol Int

View full text Add to dashboard Cite

Background:Neurosurgeons are frequently among the first physicians asked to evaluate patients with papilledema, and the patient is often referred with the implication that they may require shunting. After an initial evaluation to exclude potential neurosurgical emergencies, the physician should carefully consider various etiologies of papilledema to prevent unnecessary neurosurgical operations.Case Description:The authors report two illustrative cases of unusual causes of papilledema: Anemia and leukemic infiltration of the central nervous system. In each case, a complete blood count provided clues for the diagnosis. A review of the literature is also included.Conclusions:Both patients responded to medical management/treatment of the underlying disease and did not require neurosurgical operative intervention. Papilledema may be caused by other etiologies besides increased intracranial pressure. The authors present two unusual cases leading to papilledema and provide an outline for the workup of these conditions.

show abstract

Section: Discussionmentioning

confidence: 99%

Unusual causes of papilledema: Two illustrative cases

Nguyen

Haider²,

Ackerman³

2013

Surg Neurol Int

View full text Add to dashboard Cite

show abstract

“…There have been isolated case reports of iron deficiency as the triggering factor for raised intracranial tension. The earliest was that of Präel in 1840 and subsequent reports were those of Lubeck in 1959, followed by Pears in 1960 and Schwaber in 1961 5. The largest case control study on idiopathic intracranial hypertension carried out between 1982 and 1988 concluded that iron deficiency anaemia previously associated with idiopathic intracranial hypertension was no more common in patients than in controls;6 thus, this association was reported as spurious.…”

Section: Discussionmentioning

confidence: 99%

Iron deficiency masquerading as idiopathic intracranial hypertension

Kaul

Ramanarayanan²,

Mahapatra³

et al. 2009

Case Reports

View full text Add to dashboard Cite

A 13-year-old female presented with complaints of headache, vomiting, diplopia and progressive blurring of vision developing sequentially over 1 month. Examination revealed marked pallor and bilateral lateral rectus palsy with a visual acuity of 6/12 and 6/36 in the left and the right eye, respectively. Fundus examination showed late stage papilloedema in both eyes. Investigation for anaemia revealed severe iron deficiency. MRI of the brain was normal. The cerebrospinal fluid opening pressure was markedly raised at 320 mm of water but fluid analysis did not reveal any abnormality. Thus, a diagnosis of iron deficiency anaemia with idiopathic intracranial hypertension was made. The patient responded dramatically to intravenous iron treatment. Physicians must be aware of this rare presentation of the common problem of iron deficiency, the rapid correction of which plays an instrumental role in salvaging the patient's vision and preventing a recurrence of disease.

show abstract

“…Furthermore, due to the overgrowing red marrow, the severe IDA causes skull thickening, which in turn involves FS underdevelopment [11,96]. The IDA has also been associated with an increased ICP [97,98]. The intracranial hypertension has been supposed to be a possible underlying cause for MS persistence along with the FS underdevelopment [4,59].…”

Section: Metopic Suture Persistence and Frontal Sinus Developmentmentioning

confidence: 99%

Relation between Metopic Suture Persistence and Frontal Sinus Development

Nikolova¹,

Toneva²,

Georgiev³

et al. 2019

Challenging Issues on Paranasal Sinuses

View full text Add to dashboard Cite

The frontal bone develops as two halves, which further unite in a single bone by the closure of the mid-sagittal metopic suture, typically by the end of the first postnatal year. The frontal sinus begins to expand into the orbital and vertical plates of the frontal bone postnatally and reaches the level of the nasion by the fourth year of age. At this time, the metopic suture is usually entirely closed. However, in the cases of failed closure of the metopic suture, its relationship to the frontal sinus development is still obscure. Here, we review the relevant literature and discuss the frontal bone development and maturation, from the viewpoint of the frontal sinus pneumatization in relation to the metopic craniosynostosis and failed closure of the metopic suture. The peculiar to the metopic skulls frontal bone configuration is rather an expression of the underlying neural mass demands than a consequence of the metopic suture persistence. Furthermore, the persistent metopic suture is frequently associated with a frontal sinus underdevelopment. It seems that the metopic suture does not inhibit the frontal sinus pneumatization itself, but rather both traits are an expression or an aftereffect of a certain condition during the early development.

show abstract

Intracranial Hypertension and Iron-Deficiency Anemia

Cited by 38 publications

References 26 publications

Unusual causes of papilledema: Two illustrative cases

Unusual causes of papilledema: Two illustrative cases

Iron deficiency masquerading as idiopathic intracranial hypertension

Relation between Metopic Suture Persistence and Frontal Sinus Development

Contact Info

Product

Resources

About