Intracranial Hodgkin’s lymphoma in an HIV positive patient

Ramchandar, Kevin; Verhey, Leonard H.; Jha, Neilank K.; Murty, Naresh K.; McMillan, W. G.

doi:10.1007/s11060-008-9587-4

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…Additional 16 cases of secondary involvement of the brain or spine by HL have been described, mainly in patients with a history of autoimmune disease or immunosuppression, which may be related to HIV infection [5,[22][23][24][25][26][27]. Two of these cases were an intracranial recurrence of HL in HIV-positive male patients, with evidence of EBV infected tumor cells [23,24].…”

Section: Discussionmentioning

confidence: 99%

Primary intracranial Hodgkin’s lymphoma after a blunt trauma: A case report

Riccioni¹,

Cremonini²,

Gessaroli³

2020

J Neurosci Neurol Disord

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We report a case of 30-year-old immunocompetent man, with a previous history of cranial-facial trauma, who presented with progressive left exophthalmos due to an intracranial left frontal-ethmoidal-orbital mass. Histology of the resected tumor revealed a classical Hodgkin’s Lymphoma (HL). Epstein-Barr virus encoded RNA/EBER was detected in typical Hodgkin and Reed-Sternberg cells. After postoperative radiotherapy and chemotherapy administration, the patient remains free of systemic disease or recurrence on 4 years of follow-up. Intracranial involvement by HL has rarely been described, mostly as a late localization or as a recurrence of a disseminated disease, in a setting of immunosuppression. Primary HL of the central nervous system occurring as an isolated disease is even more uncommon, with only 16 reported cases documented to date. The prognosis of these rare cases appears comforting with appropriate treatment. Tumor resection and, in appropriate cases, treatment with radiation and/or chemotherapy seem to warrant a durable response. For this reason a systemic disease should be excluded in all cases intracranial HL by a comprehensive work-up. To the best of our knowledge, this case represents the first report that documents the association of intracranial HL and local trauma with subsequent intracranial infection.

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Section: Discussionmentioning

confidence: 99%

Primary intracranial Hodgkin’s lymphoma after a blunt trauma: A case report

Riccioni¹,

Cremonini²,

Gessaroli³

2020

J Neurosci Neurol Disord

View full text Add to dashboard Cite

show abstract

“…Meningeal involvement, though uncommon, may be diagnosed by imaging, or by an examination of the CSF . Immunodeficiency, including HIV, particularly in association with the Epstein–Barr virus, might play an etiological role . Mixed cellularity and nodular sclerosis are the common histological subtypes .…”

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confidence: 99%